1,041 research outputs found
Unicast Barrage Relay Networks: Outage Analysis and Optimization
Barrage relays networks (BRNs) are ad hoc networks built on a rapid
cooperative flooding primitive as opposed to the traditional point-to-point
link abstraction. Controlled barrage regions (CBRs) can be used to contain this
flooding primitive for unicast and multicast, thereby enabling spatial reuse.
In this paper, the behavior of individual CBRs is described as a Markov process
that models the potential cooperative relay transmissions. The outage
probability for a CBR is found in closed form for a given topology, and the
probability takes into account fading and co-channel interference (CCI) between
adjacent CBRs. Having adopted this accurate analytical framework, this paper
proceeds to optimize a BRN by finding the optimal size of each CBR, the number
of relays contained within each CBR, the optimal relay locations when they are
constrained to lie on a straight line, and the code rate that maximizes the
transport capacity.Comment: 7 pages, 4 figures, 1 table, in IEEE Military Commun. Conf. (MILCOM),
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Koagulacija krvi i lipidi u serumu (Studija stanovništva)
Two population groups differing in dietary habits and physical activity were examined on blood lipids and blood coagulability. The results showed a higher lipid concentration and shorter clotting time in the physically less active group, having a higher fat and caloric intake.Dvije populacione grupe, koje se razlikuju po svojoj prehrani, a osobito po povećanoj potrošnji masnoća i smanjenom fizičkom aktivitetu, ispitivane su s obzirom na nivo krvnih lipida i na koagulabilitet krvi. Rezultati pokazuju, da prehrana, osobito povećana potrošnja animalnih masnoća, te smanjena psihička aktivnost utječu na povećanje nivoa krvnih lipida i bržeg koagulabiliteta krvi mjerenog kao vrijeme zgrušavanja i protrombinsko vrijeme. Ti rezultati potvrđuju već ranija zapažanja autora o povećanom koagulabilitetu krvi u populacionim grupama, koje se istovremeno razlikuju i u koncentraciji krvnih lipida i u učestalosti koronarnih bolesti
Pain in Sjögren's syndrome
Sjögren's syndrome (SjS) is an autoimmune disease that affects the salivary and lacrimal glands, but it can also have extra-glandular manifestations. Although pain has not yet been fully studied and characterized, it is a symptom that can be often found in patients with SjS, who mainly complain of neuropathic pain, followed by nociceptive pain. The latter when combined with widespread dysfunctional symptoms is defined fibromyalgia. The aim of this work is to analyze the scientific literature on the presence of pain in patients with primary Sjögren's syndrome
Pain in Sjögren's syndrome.
Sjogren's syndrome (SjS) is an autoimmune disease that affects the salivary and lacrimal glands, but it can also have extra-glandular manifestations. Although pain has not yet been fully studied and characterized, it is a symptom that can be often found in patients with SjS, who mainly complain of neuropathic pain, followed by nociceptive pain. The latter when combined with widespread dysfunctional symptoms is defined fibromyalgia. The aim of this work is to analyze the scientific literature on the presence of pain in patients with primary Sjogren's syndrome
The added value of a European Reference Network on rare and complex connective tissue and musculoskeletal diseases : insights after the first 5 years of the ERN ReCONNET
Funding Information: I. Bulina has received honoraria from Abbvie, Boehringer Ingelheim, Janssen and Pfizer. N. Costedoat-Chalumeau has received grants from UCB for a clinical research study. M. Matucci-Ce rinic has received grants from Janssen and MSD, and he is a member of speak ers bureau for Janssen, Sandoz, Bio gen, BI, Lilly and MSD. A. Meyer re ceived honoraria (<10,000 euros) from Lilly, LFB, Pfizer, Boehringer, Sanofi and research grants/support from CSL Behring, LFB, Sanofi, Fresenius Kabi and BMS. L. Mouthon received a grant from LFB. J.M. van Laar has received honoraria from Abbvie, Boehringer In-gelheim, Celltrion, Galapagos, Magenta, Roche, and grants from Astra Zeneca, Boehringer Ingelheim, Roche and Thermofischer. J.K. de Vries-Bouwstra received consulting fees from Abbvie, Janssen and Boehringer Ingelheim, and research grants from Roche, Galapagos and Janssen. The other authors have declared no competing interests. Publisher Copyright: © Copyright CliniCal and ExpErimEntal rhEumatology 2022.In order to address the main challenges related to the rare diseases (RDs) the European Commission launched the European Reference Networks (ERNs), virtual networks involving healthcare providers (HCPs) across Europe. The mission of the ERNs is to tackle low prevalence and RDs that require highly specialised treatment and a concentration of knowledge and resources. In fact, ERNs offer the potential to give patients and healthcare professionals across the EU access to the best expertise and timely exchange of lifesaving knowledge, trying to make the knowledge travelling more than patients. For this reason, ERNs were established as concrete European infrastructures, and this is particularly crucial in the framework of rare and complex diseases in which no country alone has the whole knowledge and capacity to treat all types of patients. It has been five years since their kick-off launch in Vilnius in 2017. The 24 ERNs have been intensively working on different transversal areas, including patient management, education, clinical practice guidelines, patients' care pathways and many other fundamental topics. The present work is therefore aimed not only at reporting a summary of the main activities and milestones reached so far, but also at celebrating the first 5 years of the ERN on Rare and Complex Connective Tissue and Musculo-skeletal Diseases (ReCONNET), in which the members of the network built together one of the 24 infrastructures that are hopefully going to change the scenario of rare diseases across the EU.publishersversionPeer reviewe
Balancing selection, genetic drift, and human-mediated introgression interplay to shape MHC (functional) diversity in Mediterranean brown trout
The extraordinary polymorphism of major histocompatibility complex (MHC) genes is
considered a paradigm of pathogen-mediated balancing selection, although empirical
evidence is still scarce. Furthermore, the relative contribution of balancing selection
to shape MHC population structure and diversity, compared to that of neutral forces,
as well as its interaction with other evolutionary processes such as hybridization, re mains largely unclear. To investigate these issues, we analyzed adaptive (MHC-DAB
gene) and neutral (11 microsatellite loci) variation in 156 brown trout (Salmo trutta
complex) from six wild populations in central Italy exposed to introgression from do mestic hatchery lineages (assessed with the LDH gene). MHC diversity and structur ing correlated with those at microsatellites, indicating the substantial role of neutral
forces. However, individuals carrying locally rare MHC alleles/supertypes were in bet ter body condition (a proxy of individual fitness/parasite load) regardless of the zygo sity status and degree of sequence dissimilarity of MHC, hence supporting balancing
selection under rare allele advantage, but not heterozygote advantage or divergent
allele advantage. The association between specific MHC supertypes and body condi tion confirmed in part this finding. Across populations, MHC allelic richness increased
with increasing admixture between native and domestic lineages, indicating intro gression as a source of MHC variation. Furthermore, introgression across populations
appeared more pronounced for MHC than microsatellites, possibly because initially
rare MHC variants are expected to introgress more readily under rare allele advan tage. Providing evidence for the complex interplay among neutral evolutionary forces,
balancing selection, and human-mediated introgression in shaping the pattern of
MHC (functional) variation, our findings contribute to a deeper understanding of the
evolution of MHC genes in wild populations exposed to anthropogenic disturbance
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