42 research outputs found
Recent Progresses in <em>Ab Initio</em> Electronic Structure Calculation toward Understandings of Functional Mechanisms of Biological Macromolecular Systems
In this chapter, we present recent advances of theoretical analyses toward understandings of functional mechanisms of biological macromolecular systems, employing ab initio electronic structure calculations. Two distinct types of triggers to invoke dramatic rearrangements of electronic structures in the reaction centers are revealed by full ab initio quantum mechanics (QM) calculations (first example) and hybrid ab initio QM/molecular mechanics (MM) molecular dynamics (MD) calculations (second example). First, we demonstrate dramatic rearrangements of molecular orbitals (MOs) induced by binding of a hydroxyl ion (OH−) to the [4Fe-3S] cluster found in hydrogenases, which catalyzes both dissociation and production of dihydrogen (H2). This induces the significant delocalization of the LUMO, resulting in formation of electron transfer pathways required for the catalysis. Thus, in organisms, just a tiny species (e.g. OH− ligand) can play a key role for the biological functions. Second, we indicate dynamical rearrangements of MOs occurring in the enzymatic reactions of RNA-protein complexes. As the catalysis proceeds, the reactive MOs, which do not belong to the frontier orbitals in the initial stages of the reaction, are dramatically reconstituted in the hybrid ab initio QM/MM MD simulations, resulting in the frontier orbitals, which is a feature characteristic to biological macromolecular systems
Subaru Hyper Suprime-Cam Survey for An Optical Counterpart of GW170817
We perform a -band survey for an optical counterpart of a binary neutron
star coalescence GW170817 with Subaru/Hyper Suprime-Cam. Our untargeted
transient search covers deg corresponding to the credible
region of GW170817 and reaches the completeness magnitude of mag
on average. As a result, we find 60 candidates of extragalactic transients,
including J-GEM17btc (a.k.a. SSS17a/DLT17ck). While J-GEM17btc is associated
with NGC 4993 that is firmly located inside the 3D skymap of GW170817, the
other 59 candidates do not have distance information in the GLADE v2 catalog or
NASA/IPAC Extragalactic Database (NED). Among 59 candidates, 58 are located at
the center of extended objects in the Pan-STARRS1 catalog, while one candidate
has an offset. We present location, -band apparent magnitude, and time
variability of the candidates and evaluate the probabilities that they are
located inside of the 3D skymap of GW170817. The probability for J-GEM17btc is
being much higher than those for the other 59 candidates
(). Furthermore, the possibility, that at
least one of the other 59 candidates is located within the 3D skymap, is only
. Therefore, we conclude that J-GEM17btc is the most-likely and
distinguished candidate as the optical counterpart of GW170817.Comment: 14 pages, 9 figures. Accepted for publication in PASJ (Publications
of the Astronomical Society of Japan
Effectiveness of 18F-FDG PET/CT in finding lung metastasis from a retroperitoneal paraganglioma
A 50-year-old woman was diagnosed with iron deficiency anemia on general medical examination. Further, contrast-enhanced abdominal CT and magnetic resonance imaging revealed a large hypervascular mass with internal degeneration and necrosis in the retroperitoneal space. She was referred to our hospital for further evaluation and treatment. Because the paraganglioma was most likely as the imaging diagnosis, 123I-MIBG scintigraphy was performed. It revealed the marked abnormal accumulation in the retroperitoneal lesion indicating the paraganglioma and no other abnormal accumulation was noted. Several plasma catecholamines and their urinary metabolites were normal. On the subsequent 18F-FDG PET/CT, high FDG uptake was found in the retroperitoneal lesion (SUVmax=38). FDG uptake was also found in a small nodule at the base of the lower lobe of the right lung (SUVmax= 9.8). Contrast-enhanced imaging revealed a hypervascular nodule at the base of the right lung, suggesting pulmonary metastasis of a paraganglioma. The abdominal lesion and right lung nodule were excised, and retroperitoneal paraganglioma and pulmonary metastasis were diagnosed based on the pathology findings. In this case, 18F-FDG PET/CT was useful in the search for paraganglioma metastasis. We report a relationship between 123I-MIBG accumulation and 18F-FDG uptake in paraganglioma and review the relevant literature
A Substellar Companion to Pleiades HII 3441
We find a new substellar companion to the Pleiades member star, Pleiades HII
3441, using the Subaru telescope with adaptive optics. The discovery is made as
part of the high-contrast imaging survey to search for planetary-mass and
substellar companions in the Pleiades and young moving groups. The companion
has a projected separation of 0".49 +/- 0".02 (66 +/- 2 AU) and a mass of 68
+/- 5 M_J based on three observations in the J-, H-, and K_S-band. The spectral
type is estimated to be M7 (~2700 K), and thus no methane absorption is
detected in the H band. Our Pleiades observations result in the detection of
two substellar companions including one previously reported among 20 observed
Pleiades stars, and indicate that the fraction of substellar companions in the
Pleiades is about 10.0 +26.1/-8.8 %. This is consistent with multiplicity
studies of both the Pleiades stars and other open clusters.Comment: Main text (14 pages, 4 figures, 4 tables), and Supplementary data (8
pages, 3 tables). Accepted for Publications of Astronomical Society of Japa
Extreme Asymmetry in the Disk of V1247 Ori
We present the first near-infrared scattered-light detection of the
transitional disk around V1247 Ori, which was obtained using high-resolution
polarimetric differential imaging observations with Subaru/HiCIAO. Our imaging
in the H band reveals the disk morphology at separations of ~0.14"-0.86"
(54-330 au) from the central star. The polarized intensity (PI) image shows a
remarkable arc-like structure toward the southeast of the star, whereas the
fainter northwest region does not exhibit any notable features. The shape of
the arm is consistent with an arc of 0.28" 0.09" in radius (108 au from
the star), although the possibility of a spiral arm with a small pitch angle
cannot be excluded. V1247 Ori features an exceptionally large azimuthal
contrast in scattered, polarized light; the radial peak of the southeastern arc
is about three times brighter than the northwestern disk measured at the same
distance from the star. Combined with the previous indication of an
inhomogeneous density distribution in the gap at 46 au, the notable
asymmetry in the outer disk suggests the presence of unseen companions and/or
planet-forming processes ongoing in the arc.Comment: 21 pages, 5 figures, accepted for publication in PAS
An international survey of physicians regarding clinical trials: a comparison between Kyoto University Hospital and Seoul National University Hospital
This is an open access article distributed under the terms of the Creative
Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and
reproduction in any medium, provided the original work is properly cited.Abstract
Background
International clinical trials are now rapidly expanding into Asia. However, the proportion of global trials is higher in South Korea compared to Japan despite implementation of similar governmental support in both countries. The difference in clinical trial environment might influence the respective physicians attitudes and experience towards clinical trials. Therefore, we designed a questionnaire to explore how physicians conceive the issues surrounding clinical trials in both countries.
Methods
A questionnaire survey was conducted at Kyoto University Hospital (KUHP) and Seoul National University Hospital (SNUH) in 2008. The questionnaire consisted of 15 questions and 2 open-ended questions on broad key issues relating to clinical trials.
Results
The number of responders was 301 at KUHP and 398 at SNUH. Doctors with trial experience were 196 at KUHP and 150 at SNUH. Among them, 12% (24/196) at KUHP and 41% (61/150) at SUNH had global trial experience. Most respondents at both institutions viewed clinical trials favorably and thought that conducting clinical trials contributed to medical advances, which would ultimately lead to new and better treatments. The main reason raised as a hindrance to conducting clinical trials was the lack of personnel support and time. Doctors at both university hospitals thought that more clinical research coordinators were required to conduct clinical trials more efficiently. KUHP doctors were driven mainly by pure academic interest or for their desire to find new treatments, while obtaining credits for board certification and co-authorship on manuscripts also served as motivation factors for doctors at SNUH.
Conclusions
Our results revealed that there might be two different approaches to increase clinical trial activity. One is a social level approach to establish clinical trial infrastructure providing sufficient clinical research professionals. The other is an individual level approach that would provide incentives to encourage doctors to participate in and conduct clinical trials
Extreme Asymmetry in the Polarized Disk of V1247 Orionis *
We present the first near-infrared scattered-light detection of the transitional disk around V1247 Ori, which was obtained using high-resolution polarimetric differential imaging observations with Subaru/HiCIAO. Our imaging in the H band reveals the disk morphology at separations of 0.′′14–0.′′86 (54–330 au) from the central star. The polarized intensity (PI) image shows a remarkable arc-like structure toward the southeast of the star, whereas the fainter northwest region does not exhibit any notable features. The shape of the arm is consistent with an arc of 0.′′28 0.′′09 in radius (108 au from the star), although the possibility of a spiral arm with a small pitch angle cannot be excluded. V1247 Ori features an exceptionally large azimuthal contrast in scattered, polarized light; the radial peak of the southeastern arc is about three times brighter than the northwestern disk measured at the same distance from the star. Combined with the previous indication of an inhomogeneous density distribution in the gap at < 46 au, the notable asymmetry in the outer disk suggests the presence of unseen companions and/or planet-forming processes ongoing in the arc.This work is supported by MEXT KAKENHI Nos. 23103005. S.K. acknowledges support from an STFC Ernest Rutherford Fellowship (ST/J004030/1) and Marie Curie CIG grant (SH-06192)