同一患者由来の大腸がんオルガノイド比較解析によるOLFM4陽性がん幹細胞の同定と転移再発に伴う細胞多様性の変化

京都大学新制・課程博士博士(医学)甲第23572号医博第4786号新制||医||1054(附属図書館)京都大学大学院医学研究科医学専攻(主査)教授 妹尾 浩, 教授 武藤 学, 教授 小川 誠司学位規則第4条第1項該当Doctor of Medical ScienceKyoto UniversityDFA

Scalable Socket Buffer Tuning for High-Performance Web Servers

Although many research efforts have been devoted to network congestion in the face of an increase in the Internet traffic, there is little recent discussion on performance improvements for endhosts. In this paper, we propose a new architecture, called Scalable Socket Buffer Tuning (SSBT), to provide high-performance and fair service for many TCP connections at Internet endhosts. SSBT has two major features. One ist to reduce the number..

Physical Relation of Source I to IRc2 in the Orion KL Region

We present mid-infrared narrow-band images of the Orion BN/KL region, and N-band low-resolution spectra of IRc2 and the nearby radio source "I." The distributions of the silicate absorption strength and the color temperature have been revealed with a sub-arcsecond resolution. The detailed structure of the 7.8 micron/12.4 micron color temperature distribution was resolved in the vicinity of IRc2. A mid-infrared counterpart to source I has been detected as a large color temperature peak. The color temperature distribution shows an increasing gradient from IRc2 toward source I, and no dominant temperature peak is seen at IRc2. The spectral energy distribution of IRc2 could be fitted by a two-temperature component model, and the "warmer component" of the infrared emission from IRc2 could be reproduced by scattering of radiation from source I. IRc2 itself is not self-luminous, but is illuminated and heated by an embedded luminous young stellar object located at source I.Comment: 20 pages, 11 figures. Minor corrections had been done in the ver.2. Accepted for publication in PAS

A Method of Dynamic Interconnection of VLANs for Large Scale VLAN Environment

VLAN (Virtual LAN) is a technology which can configure logical networks independent of the physi cal network structure. With VLAN, users in common spaces (such as meeting rooms) can access to their department networks temporarily because changing of logical network structure is achieved only by con figuration of VLAN switches. However, in the general configuration method, because VLANs are managed statically by admin istrators, various problems such as high adminis trative cost and conflict or insufficiency of VLAN IDs may arise especially in large scale organiza tions where VLANs are managed by each depart ment. To solve these problems, we propose a method which provides an interconnection between a tem porary configured VLAN in a common space and a VLAN of a user’s department. In the proposed method, a user in a common space can access to his/her department network seamlessly by convert ing a temporary VLAN-ID in the common space and a VLAN-ID used in his/her department each other automatically. The effectiveness of the pro posed method is confirmed by the experiment on the actual network using VLAN managers, VLAN ID converters and authentication servers based on the proposed method. </p

Novel PTCH1 mutation in Gorlin syndrome

Gorlin syndrome is an autosomal dominant disorder characterized by a wide range of developmental abnormalities and a predisposition to various tumors, and it is linked to the alteration of several causative genes, including PTCH1. We performed targeted resequencing using a next-generation sequencer to analyze genes associated with known clinical phenotypes in an 11-year-old male with sporadic jaw keratocysts. A novel duplication mutation (c.426dup) in PTCH1, resulting in a truncated protein, was identified