Analects of Japanese scholars of the Chinese classics in the Edo Period and others : Kawaguchi Seisai Heihitsuroku

江戸時代における随筆類の文学史的研究は、いまだ充分になされているとは言い難い。本稿では、こうした現状から前進すべく、随筆のうちでも、特に漢学者の言葉を書き留めた「語録」とでも呼ぶべきものをとりあげて、その文学史的意義を考察する。より具体的に言えば、江戸時代中期の漢学者河口静斎（元禄十六＜一七〇三＞－宝暦四＜一七五四＞の語録『秉筆録』（祐徳稲荷神社祐徳博物館所蔵写本四冊）を材料とし、本書が、新旧の交替のめまぐるしい正徳、享保文壇を如実に物語る好資料であること、また、木下順庵門下、いわゆる「木門」の人々の直談やエピソードを多く含んで、木門を知るうえでも有用であることを明らかにする

A Study on Toshisen Karuta that Suzando Kobayashi Shinbei published

中国明代の李攀龍撰とされる『唐詩選』中の絶句をかるたに作って遊ぶということは、中国では行われず日本独自の習慣である。これは、我が国においてこの唐詩総集がいかに親しまれていたかを示す現象であり、日本における『唐詩選』受容史のうえで看過できない研究課題である。しかしこれまで、嵩山房（『唐詩選』関連書を独占して出版し続けた江戸の書肆）が売り出した「唐詩選かるた」について、充分な検討は加えられてはいない。よって可能なかぎり実物に即しながら、このかるたの種類、制作の経緯、刊行年時などを考察して、日本における『唐詩選』受容史の一端を明らかにしたい。departmental bulletin pape

Toshisen-jisho and Toshi-kokujiben

我が国における『唐詩選』受容史研究において、これまで充分に検討されていない本橋霞岫著『唐詩選事証』（明和五年跋刊）の成立経緯を明らかにする。その結果、本書の注釈の多くが、『唐詩選国字弁』（従来、伝存未詳の書とされる）、『唐詩要解』（明和六年刊）という岡島竹隖（生没年未詳）が著した二つの注釈書に依拠している点、そして竹隖の『唐詩選国字弁』は実は、京都の書肆文林軒田原勘兵衛から著者名を伏せて出版された『唐詩国字弁』（明和三年～七年刊）のことであった点を指摘する。先行研究では、田原刊『唐詩国字弁』の著者は宇野東山（享保二十年ー文化十年）であると考えられていたが、本稿ではそれに異を唱え、後に江戸の書肆嵩山房小林新兵衛が服部南郭の講義筆記と銘打つ『唐詩選国字解』（天明二年刊）を出版した背景の一つを明らかにする。departmental bulletin pape

Structural, Magnetic, and Electrochemical Characterization of Iron(III) and Cobalt Complexes with Penta-N3O2-dentate Ligands

Six new mononuclear [FeIII(LBr,Cl)X]-complexes (LBr,Cl is the dianionic penta-N3O2-dentate Schiff base ligand N,N′-bis(2’-hydroxy-3-bromo-5-chlorobenzylidene)-1,6-diamino-3-azahexane; X: Cl−, N3−, NCO−, NCS−, NCSe−, CN−) were synthesized and their structures, magnetic and electrochemical properties studied. Structure analysis and magnetic measurements showed that [FeIII(LBr,Cl)CN] is in the low spin state and the other five complexes are in high spin states. Furthermore, the trinuclear mixed valent cobalt complex {[CoIII(LH,H)CN]2[CoII(1-methylimidazole)3(H2O)]} was prepared and its magnetic behavior studied. © 2021 The Authors. European Journal of Inorganic Chemistry published by Wiley-VCH Gmb

The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

「コロナ制圧タスクフォース」COVID-19患者由来の血液細胞における遺伝子発現の網羅的解析 --重症度に応じた遺伝子発現の変化には、ヒトゲノム配列の個人差が影響する--. 京都大学プレスリリース. 2022-08-23.Coronavirus disease 2019 (COVID-19) is a recently-emerged infectious disease that has caused millions of deaths, where comprehensive understanding of disease mechanisms is still unestablished. In particular, studies of gene expression dynamics and regulation landscape in COVID-19 infected individuals are limited. Here, we report on a thorough analysis of whole blood RNA-seq data from 465 genotyped samples from the Japan COVID-19 Task Force, including 359 severe and 106 non-severe COVID-19 cases. We discover 1169 putative causal expression quantitative trait loci (eQTLs) including 34 possible colocalizations with biobank fine-mapping results of hematopoietic traits in a Japanese population, 1549 putative causal splice QTLs (sQTLs; e.g. two independent sQTLs at TOR1AIP1), as well as biologically interpretable trans-eQTL examples (e.g., REST and STING1), all fine-mapped at single variant resolution. We perform differential gene expression analysis to elucidate 198 genes with increased expression in severe COVID-19 cases and enriched for innate immune-related functions. Finally, we evaluate the limited but non-zero effect of COVID-19 phenotype on eQTL discovery, and highlight the presence of COVID-19 severity-interaction eQTLs (ieQTLs; e.g., CLEC4C and MYBL2). Our study provides a comprehensive catalog of whole blood regulatory variants in Japanese, as well as a reference for transcriptional landscapes in response to COVID-19 infection

DOCK2 is involved in the host genetics and biology of severe COVID-19

「コロナ制圧タスクフォース」COVID-19疾患感受性遺伝子DOCK2の重症化機序を解明 --アジア最大のバイオレポジトリーでCOVID-19の治療標的を発見--. 京都大学プレスリリース. 2022-08-10.Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge. Here we conducted a genome-wide association study (GWAS) involving 2, 393 cases of COVID-19 in a cohort of Japanese individuals collected during the initial waves of the pandemic, with 3, 289 unaffected controls. We identified a variant on chromosome 5 at 5q35 (rs60200309-A), close to the dedicator of cytokinesis 2 gene (DOCK2), which was associated with severe COVID-19 in patients less than 65 years of age. This risk allele was prevalent in East Asian individuals but rare in Europeans, highlighting the value of genome-wide association studies in non-European populations. RNA-sequencing analysis of 473 bulk peripheral blood samples identified decreased expression of DOCK2 associated with the risk allele in these younger patients. DOCK2 expression was suppressed in patients with severe cases of COVID-19. Single-cell RNA-sequencing analysis (n = 61 individuals) identified cell-type-specific downregulation of DOCK2 and a COVID-19-specific decreasing effect of the risk allele on DOCK2 expression in non-classical monocytes. Immunohistochemistry of lung specimens from patients with severe COVID-19 pneumonia showed suppressed DOCK2 expression. Moreover, inhibition of DOCK2 function with CPYPP increased the severity of pneumonia in a Syrian hamster model of SARS-CoV-2 infection, characterized by weight loss, lung oedema, enhanced viral loads, impaired macrophage recruitment and dysregulated type I interferon responses. We conclude that DOCK2 has an important role in the host immune response to SARS-CoV-2 infection and the development of severe COVID-19, and could be further explored as a potential biomarker and/or therapeutic target