Optimal design of efficient IPM motor using finite element method

Techniques for the optimal design of permanent magnet motors considering rotation are investigated. The nonconforming mesh technique is used to take into account the rotation of the rotor. It is shown that the technique is especially useful for the optimal design using the finite element method, because no modification of mesh is necessary during the rotation. The mesh at each angle of rotation can be obtained by only combining meshes of a rotor and a stator. By using the combined optimization technique of the experimental design method and Rosenbrock's method, the number of FEM calculations can be reduced. By applying the optimal design method, about 40% of volume of permanent magnet of IPM motor and about 15% of the torque ripple can be reduced</p

Energy Spectra of Quantum Turbulence: Large-scale Simulation and Modeling

In $2048^3$ simulation of quantum turbulence within the Gross-Pitaevskii equation we demonstrate that the large scale motions have a classical Kolmogorov-1941 energy spectrum E(k) ~ k^{-5/3}, followed by an energy accumulation with E(k) ~ const at k about the reciprocal mean intervortex distance. This behavior was predicted by the L'vov-Nazarenko-Rudenko bottleneck model of gradual eddy-wave crossover [J. Low Temp. Phys. 153, 140-161 (2008)], further developed in the paper.Comment: (re)submitted to PRB: 5.5 pages, 4 figure

Development of the basal hypothalamus through anisotropic growth

The adult hypothalamus is subdivided into distinct domains: pre‐optic, anterior, tuberal and mammillary. Each domain harbours an array of neurones that act together to regulate homeostasis. The embryonic origins and the development of hypothalamic neurones, however, remain enigmatic. Here, we summarise recent studies in model organisms that challenge current views of hypothalamic development, which traditionally have attempted to map adult domains to correspondingly located embryonic domains. Instead, new studies indicate that hypothalamic neurones arise from progenitor cells that undergo anisotropic growth, expanding to a greater extent than other progenitors, and grow in different dimensions. We describe in particular how a multipotent Shh/Fgf10‐expressing progenitor population gives rise to progenitors throughout the basal hypothalamus that grow anisotropically and sequentially: first, a subset displaced rostrally give rise to anterior‐ventral/tuberal neuronal progenitors; then a subset displaced caudally give rise to mammillary neuronal progenitors; and, finally, a subset(s) displaced ventrally give rise to tuberal infundibular glial progenitors. As this occurs, stable populations of Shh+ive and Fgf10+ive progenitors form. We describe current understanding of the mechanisms that induce Shh+ive/Fgf10+ive progenitors and begin to direct their differentiation to anterior‐ventral/tuberal neuronal progenitors, mammillary neuronal progenitors and tuberal infundibular progenitors. Taken together, these studies suggest a new model for hypothalamic development that we term the “anisotropic growth model”. We discuss the implications of the model for understanding the origins of adult hypothalamic neurones

Probing the Functional Mechanism of Escherichia coli GroEL Using Circular Permutation

Background: The Escherichia coli chaperonin GroEL subunit consists of three domains linked via two hinge regions, and each domain is responsible for a specific role in the functional mechanism. Here, we have used circular permutation to study the structural and functional characteristics of the GroEL subunit. Methodology/Principal Findings: Three soluble, partially active mutants with polypeptide ends relocated into various positions of the apical domain of GroEL were isolated and studied. The basic functional hallmarks of GroEL (ATPase and chaperoning activities) were retained in all three mutants. Certain functional characteristics, such as basal ATPase activity and ATPase inhibition by the cochaperonin GroES, differed in the mutants while at the same time, the ability to facilitate the refolding of rhodanese was roughly equal. Stopped-flow fluorescence experiments using a fluorescent variant of the circularly permuted GroEL CP376 revealed that a specific kinetic transition that reflects movements of the apical domain was missing in this mutant. This mutant also displayed several characteristics that suggested that the apical domains were behaving in an uncoordinated fashion. Conclusions/Significance: The loss of apical domain coordination and a concomitant decrease in functional ability highlights the importance of certain conformational signals that are relayed through domain interlinks in GroEL. W

Field-induced phase transitions in a Kondo insulator

We study the magnetic-field effect on a Kondo insulator by exploiting the periodic Anderson model with the Zeeman term. The analysis using dynamical mean field theory combined with quantum Monte Carlo simulations determines the detailed phase diagram at finite temperatures. At low temperatures, the magnetic field drives the Kondo insulator to a transverse antiferromagnetic phase, which further enters a polarized metallic phase at higher fields. The antiferromagnetic transition temperature $T_c$ takes a maximum when the Zeeman energy is nearly equal to the quasi-particle gap. In the paramagnetic phase above $T_c$, we find that the electron mass gets largest around the field where the quasi-particle gap is closed. It is also shown that the induced moment of conduction electrons changes its direction from antiparallel to parallel to the field.Comment: 7 pages, 6 figure

Evidence for Spin–Orbit Alignment in the TRAPPIST-1 System

In an effort to measure the Rossiter–McLaughlin effect for the TRAPPIST-1 system, we performed high-resolution spectroscopy during transits of planets e, f, and b. The spectra were obtained with the InfraRed Doppler spectrograph on the Subaru 8.2 m telescope, and were supplemented with simultaneous photometry obtained with a 1 m telescope of the Las Cumbres Observatory Global Telescope. By analyzing the anomalous radial velocities, we found the projected stellar obliquity to be λ = 1 ± 28° under the assumption that the three planets have coplanar orbits, although we caution that the radial-velocity data show correlated noise of unknown origin. We also sought evidence for the expected deformations of the stellar absorption lines, and thereby detected the "Doppler shadow" of planet b with a false-alarm probability of 1.7%. The joint analysis of the observed residual cross-correlation map including the three transits gave λ = 19_(-15)^(+13)°. These results indicate that the the TRAPPIST-1 star is not strongly misaligned with the common orbital plane of the planets, although further observations are encouraged to verify this conclusion

Implementation of earlier antibiotic administration in patients with severe sepsis and septic shock in Japan: a descriptive analysis of a prospective observational study.

BACKGROUND: Time to antibiotic administration is a key element in sepsis care; however, it is difficult to implement sepsis care bundles. Additionally, sepsis is different from other emergent conditions including acute coronary syndrome, stroke, or trauma. We aimed to describe the association between time to antibiotic administration and outcomes in patients with severe sepsis and septic shock in Japan. METHODS: This prospective observational study enrolled 1184 adult patients diagnosed with severe sepsis based on the Sepsis-2 criteria and admitted to 59 intensive care units (ICUs) in Japan between January 1, 2016, and March 31, 2017, as the sepsis cohort of the Focused Outcomes Research in Emergency Care in Acute Respiratory Distress Syndrome, Sepsis and Trauma (FORECAST) study. We compared the characteristics and in-hospital mortality of patients administered with antibiotics at varying durations after sepsis recognition, i.e., 0-60, 61-120, 121-180, 181-240, 241-360, and 361-1440 min, and estimated the impact of antibiotic timing on risk-adjusted in-hospital mortality using the generalized estimating equation model (GEE) with an exchangeable, within-group correlation matrix, with "hospital" as the grouping variable. RESULTS: Data from 1124 patients in 54 hospitals were used for analyses. Of these, 30.5% and 73.9% received antibiotics within 1 h and 3 h, respectively. Overall, the median time to antibiotic administration was 102 min [interquartile range (IQR), 55-189]. Compared with patients diagnosed in the emergency department [90 min (IQR, 48-164 min)], time to antibiotic administration was shortest in patients diagnosed in ICUs [60 min (39-180 min)] and longest in patients transferred from wards [120 min (62-226)]. Overall crude mortality was 23.4%, where patients in the 0-60 min group had the highest mortality (28.0%) and a risk-adjusted mortality rate [28.7% (95% CI 23.3-34.1%)], whereas those in the 61-120 min group had the lowest mortality (20.2%) and risk-adjusted mortality rates [21.6% (95% CI 16.5-26.6%)]. Differences in mortality were noted only between the 0-60 min and 61-120 min groups. CONCLUSIONS: We could not find any association between earlier antibiotic administration and reduction in in-hospital mortality in patients with severe sepsis

Star Formation Timescales of the Halo Populations from Asteroseismology and Chemical Abundances

We combine asteroseismology, optical high-resolution spectroscopy, and kinematic analysis for 26 halo red giant branch stars in the \textit{Kepler} field in the range of $-2.5<[\mathrm{{Fe}/{H}}]<-0.6$. After applying theoretically motivated corrections to the seismic scaling relations, we obtain an average mass of $0.97\pm 0.03\,\mathrm{M_{\odot}}$ for our sample of halo stars. Although this maps into an age of $\sim 7\,\mathrm{Gyr}$, significantly younger than independent age estimates of the Milky Way stellar halo, we considerer this apparently young age is due to the overestimation of stellar mass in the scaling relations. There is no significant mass dispersion among lower red giant branch stars ($\log g>2$), which constrains a relative age dispersion to $<18\%$, corresponding to $<2\,\mathrm{Gyr}$. The precise chemical abundances allow us to separate the stars with [{Fe}/{H}]$>-1.7$ into two [{Mg}/{Fe}] groups. While [$\alpha$/{Fe}] and [{Eu}/{Mg}] ratios are different between the two subsamples, [$s$/Eu], where $s$ stands for Ba, La, Ce, and Nd, does not show a significant difference. These abundance ratios suggest that the chemical evolution of the low-Mg population is contributed by type~Ia supernovae, but not by low-to-intermediate mass asymptotic giant branch stars, providing a constraint on its star formation timescale as $100\,\mathrm{Myr}<\tau<300\,\mathrm{Myr}$. We also do not detect any significant mass difference between the two [{Mg}/{Fe}] groups, thus suggesting that their formation epochs are not separated by more than 1.5 Gyr.Comment: 44 pages. accepted versio