Generalized Estimating Equation Regression Analyses for Optical Coherence Tomography Parameters in Aquaporin-4 Antibody-Positive Eyes.

<p>Generalized Estimating Equation Regression Analyses for Optical Coherence Tomography Parameters in Aquaporin-4 Antibody-Positive Eyes.</p

Retinal Structure Correlations with Ab Titer in the AQP4 Ab-Positive Group.

<p>Retinal Structure Correlations with Ab Titer in the AQP4 Ab-Positive Group.</p

Structure−function relationships in all eyes.

<p>Scatter plots of mean deviation (MD) against circumpapillary retinal nerve fiber layer (RNFL) average thickness (A), MD against ganglion cell complex (GCC) average thickness (B), logMAR visual acuity (VA) against circumpapillary RNFL average thickness (C), and VA against GCC average thickness (D). Open circles and dotted lines indicate eyes with aquaporin 4 antibody (AQP4 Ab)-negative optic neuritis, whereas closed circles and solid lines indicate eyes with antibody-positive optic neuritis. Spearman rank correlation coefficients (95% confidence interval, P-value) for the AQP4 Ab-negative and positive-groups were 0.33 (-0.22 to 0.72, 0.23) and 0.74 (0.44 to 0.89, 0.0002), respectively, between MD and average RNFL thickness (A), 0.49 (-0.03 to 0.80, 0.06) and 0.73 (0.43 to 0.89, 0.0002), respectively, between MD and average GCC thickness (B), -0.57 (-0.84 to -0.07, 0.03) and -0.40 (-0.71 to 0.06, 0.08), respectively, between logMAR VA and average RNFL thickness (C), and -0.69 (-0.89 to -0.27, 0.005) and -0.52 (-0.78 to -0.10, 0.02), respectively, between logMAR VA and average GCC thickness (D).</p

Receiver Operating Characteristic Curve Analyses for Factors Discriminating AQP4 Ab Positivity.

<p>Receiver Operating Characteristic Curve Analyses for Factors Discriminating AQP4 Ab Positivity.</p

Generalized Estimating Equation Regression Analyses for Factors associated with Visual Function in Aquaporin-4 Antibody-Negative Eyes.

<p>Generalized Estimating Equation Regression Analyses for Factors associated with Visual Function in Aquaporin-4 Antibody-Negative Eyes.</p

Structure−function relationships in eyes with single-episode optic neuritis.

<p>Scatter plots of mean deviation (MD) against circumpapillary retinal nerve fiber layer (RNFL) average thickness (A), MD against ganglion cell complex (GCC) thickness (B), logMAR visual acuity (VA) against circumpapillary RNFL average thickness (C), and VA against GCC average thickness (D). Open circles and dotted lines indicate eyes with aquaporin 4 antibody (AQP4 Ab)-negative optic neuritis, whereas closed circles and solid lines indicate eyes with antibody-positive optic neuritis. Spearman rank correlation coefficients (95% confidence interval, P-value) for the antibody-negative and -positive groups were 0.39 (-0.24 to 0.79, 0.22) and 0.75 (0.27 to 0.93, 0.008), respectively, between MD and average RNFL thickness (A), 0.58 (0.01 to 0.87, 0.05) and 0.77 (0.32 to 0.94, 0.006), respectively, between MD and average GCC thickness (B), -0.47 (-0.82 to 0.14, 0.12) and -0.39 (-0.80 to 0.28, 0.24), respectively, between logMAR VA and average RNFL thickness (C), and -0.65 (-0.89 to -0.11, 0.02) and -0.62 (-0.89 to -0.02, 0.04), respectively, between logMAR VA and average GCC thickness (D).</p

Impact of the anti-aquaporin-4 autoantibody on inner retinal structure, function and structure-function associations in Japanese patients with optic neuritis - Fig 1

<p><b>Representative cases of aquaporin-4 antibody (AQP4 Ab)-positive (A−C) and -negative (D−F) optic neuritis in the left eye.</b> Shown are optic nerve head maps (A, D) and GCC significance maps (B, E) from RTVue optical coherence tomography analyses, and gray scales (C, F) of Humphrey visual field 30–2 tests. Tests were conducted 6.5 years and 4.5 years after the latest onset of optic neuritis in the seropositive and negative case, respectively.</p

Eye-based characteristics.

<p>Eye-based characteristics.</p

Generalized Estimating Equation Regression Analyses for Factors associated with Visual Function in Aquaporin-4 Antibody-Positive Eyes.

<p>Generalized Estimating Equation Regression Analyses for Factors associated with Visual Function in Aquaporin-4 Antibody-Positive Eyes.</p

Excessive scleral shrinkage, rather than choroidal thickening, is a major contributor to the development of hypotony maculopathy after trabeculectomy - Fig 1

<p><b>Scatter plots of percent change of AL with (A) age, (B) preoperative AL, and (C) postoperative intraocular pressure.</b> AL, axial length; IOP, intraocular pressure. Closed circles indicate eyes with hypotony maculopathy, whereas open circles indicate those without hypotony maculopathy. Dotted lines indicate a cut-off line of 2% reduction rate of AL.</p