Characterization of prostate cancer detected at repeat biopsy

Research articl

2019 年度看護学部教育課程の改定について

紀要委員会企画Special Articles　本稿は、本学看護学部の2019 年度教育課程改定における活動内容の概要を記した。2012 年に教育課程変更を行って５年が経過したことや、教育職員免許法の改正により養護教諭課程の再課程認定に伴い、2019 年度に向けて看護学部教育課程の改定を行うことになった。2017 年度からカリキュラム検討委員会を中心に教育課程の検討を行い、２年間に渡って教育課程改定に向けて活動した内容をまとめた。2019 年度新教育課程としては、地域包括ケアシステムの推進に基づく社会の変遷にあわせた教育課程へと発展させるための学修内容の追加、本学の強みである充実した実習環境をもとに行われている臨地看護学実習を通して「生命の尊厳と隣人愛」に基づく教育理念を継続的に意識づけられるような教育課程を策定することができた。指定規則改正に伴う次の教育課程の改定に向けて、今回のプロセスが参考となることを期待する

Immobilization and collection of enzymes by hydroxyapatite/maghemite composite particles with magnetism

Feature: The 58th Symposium on Basic Science of CeramicsApatite nuclei (ApN) were precipitated by raising the pH of simulated body fluid (SBF) with ion concentrations nearly equal to those of human blood plasma. The maghemite (γ-Fe2O3) particles were attached to the ApN, and the particles were subsequently soaked in SBF adjusted at pH = 7.60, 36.5 °C for one day. By this treatment, the ApN induced hydroxyapatite (HA) formation and the γ-Fe2O3 particles were encapsulated with HA particles with approximately 1–2 µm in diameter. The specific surface area of thus-obtained HA/Fe2O3 particles was almost 27 times as large as that of the commercially obtained HA particles. Urease or superoxide dismutase (SOD) was immobilized on the surface of the HA/Fe2O3 particles in ultrapure water, and the particles were collected by using a neodymium magnet. It was indicated that more than 90 % of urease or SOD was collected by using the HA/Fe2O3 particles. By using the urease immobilized on the HA/Fe2O3 particles, furthermore, urea dispersed in buffered solution almost completely decomposed. As the immobilization efficiency of urease increased, the urea decomposition was promoted

In Situ Observation of a Self-Assembled Monolayer Formation of Octadecyltrimethoxysilane on a Silicon Oxide Surface Using a High-Speed Atomic Force Microscope

The formation mechanism of a self-assembled monolayer (SAM) of octadecyltrimethoxysilane on a silicon oxide surface in reaction is studied in situ by using a high-speed atomic force microscope that has a time resolution of 2 s per frame. The SAM formation of a silane coupling reagent on silicon is known to comprise three development stages of nucleation, growth, and coalescence. In the present study, the first nucleation stage is found to have dynamical processes: a molecular cluster attached to the substrate works as a reaction base, on which additional reactive molecules are in a bind/unbind equilibrium. In this time period, the cluster needs a long time to develop in diameter. Once a domain of ca. 30 nm in diameter is formed, the reaction rate is changed, which is dominated by the rim length of the domain. This implies that the weakly adsorbing limit approximation on the substrate surface can be employed. Another important point is that the molecular domains generate a SAM like an occupied sheet of tiles, and each tile is connected to the substrate by a few feet. In fact, a molecular tile can easily be removed by applying soft air plasma leaving the rest of the tiles of highly packed molecules, which is confirmed by infrared p-polarized external reflection spectroscopy

EFFECT OF CARDIAC OUTPUT ON PULMONARY SHUNT

The effect of cardiac output on pulmonary shunt was studied in living lungs of human patients and dogs which had alveoli and blood vessels, and also in artificial lung (bubble-type oxygenator) which, had no such structural factors. In spite of such a structural difference, quite similar results were observed in both living and artificial lungs, and this suggests that some common factors other than the change in blood vessels result in the change in pulmonary shunt. It was observed that pulmonary shunt increased as the saturation of mixed venous blood became higher. It was clarified that the oxygen receiving capacity of blood decreased as the oxygen saturation became higher, i.e., the amount of reduced hemoglobin became less. The reduction in oxygen-receiving capacity of blood results in the leduction in oxygen-transfer efficiency from alveoli to blood and hence pulmonary shunt increases, and this can be regarded as a kind of shunt-like effect. It can be concluded that the change in pulmonary shunt by cardiac output is not due to the change in the lung function but is caused by the change in the oxygen-receiving capacity of the mixed venous blood