A Yokomizo

B Djavan

DF Gleason

E Lopez-Corona

H Miyake

H Steiner

International Union against Cancer

JE Busby

KJ Gancarczyk

Mitsuru Saito

MS Cookson

Norihiko Tsuchiya

PG Borboroglu

RC Ouyang

Shigeru Satoh

Shintaro Narita

SJ Freedland

SJ Park

Takamitsu Inoue

Takeshi Yuasa

Teruaki Kumazawa

Tomonori Habuchi

Yohei Horikawa

English

PubMed

Springer - Publisher Connector

Characterization of prostate cancer detected at repeat biopsy

Crossref

Abstract Background The aim of this study was to investigate the characteristics of prostate cancer patients who were diagnosed at repeat biopsy and compare them to non-cancerous patients or patients who were diagnosed at initial biopsy. Methods We carried out a retrospective analysis of clinical and pathological data from 576 patients, which included data on the period of time from radical prostatectomy to biochemical failure. Results Cancer was diagnosed in 191 (33%) of 576 patients at initial biopsy and in 23 (18%) of 127 patients who underwent a repeat biopsy. Cut-off values of 0.80 and 0.30 for prostate specific antigen velocity (PSAV) and prostate specific antigen density (PSAD), respectively, were determined using ROC curve analysis. Based on these values, PSAV and PSAD were able to predict 94% (46 of 49) of negative repeat biopsies, indicating that these patients had undergone unnecessary repeat biopsies. Although the patients who were diagnosed at repeat biopsy had a higher rate of organ-confined tumor than those who were diagnosed at initial biopsy (73% and 44%, respectively; P = 0.041), there were no differences in the recurrence rate or the duration of biochemical failure-free survival between the two groups. Conclusion PSAV and PSAD may be useful indicators of the results of repeat biopsies. Although prostate cancer that was diagnosed at repeat biopsy was associated with a more favorable pathological profile, it was not associated with a better outcome after radical prostatectomy.</p

Saito Mitsuru

Narita Shintaro

Inoue Takamitsu

Kumazawa Teruaki

Tsuchiya Norihiko

Yuasa Takeshi

Horikawa Yohei

Satoh Shigeru

Habuchi Tomonori

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Characterization of prostate cancer detected at repeat biopsy

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