Congenital Dysfibrinogenemia Presented with Massive Hematomas Formed after Hysterectomy

ArticleCase Reports in Clinical Medicine. 10: 108-116 (2021)journal articl

The Genetic Diversity of Helicobacter pylori Virulence Genes Is Not Associated with Gastric Atrophy Progression

Atrophy of the gastric mucosa is a precursor of intestinal-type gastric cancer, and Helicobacter pylori infection causes atrophic gastritis. The aim of this study was to determine whether the genetic diversity of H. pylori virulence genes is associated with the development and progression of gastric atrophy in humans. We isolated and cultured H. pylori strains from patients with gastric ulcer and duodenal ulcer accompanied by atrophic gastritis in background mucosa. H. pylori strains were stored at －80℃ prior to the experiments being carried out. We analyzed iceA, babA, vacA, cagA, and cagE genes by PCR. The cagA gene was analyzed through sequencing of the C-terminal region containing the EPIYA motif, which is related to tyrosine phosphorylation. Severe atrophy was observed in patients with gastric ulcer. The major phenotype of the vacA gene was s1c/m1 (93ｵ). The cagA gene was detected in all strains. The cagE gene was not detected in 2 and 5 strains from the mild cases and severe cases, respectively. The major cagA EPIYA motif, which is amino acids repeat in the C terminus, was the A-B-D type (44 of 58 strains). The virulence genes were not statistically associated with the severity of atrophy in the background gastric mucosa in humans. Not only identification of bacterial virulence factors but also studies of the host response will be necessary to investigate the progression of gastric atrophy and subsequent cancer development in humans

2004 ネン タイフウ 21 ゴウ ゴウウ ニヨリ カガワケン セイサン チイキ デ ハッセイ シタ シャメン ホウカイ ノ チシツ チケイテキ トクチョウ

Many slope failures and debris flows triggered by heavy rainfall associated with Typhoon 0421 occurred in Seisan area, Kagawa Prefecture, Japan. Critical rainfall to trigger the slope failure is 65mm/h, 150mm/3h, total precipitation 250mm, and soil water index 180. Many slope failures occurred at side-slope and/or debris filled floor of 1-order valley in mountain slopes consisting of alternating beds of sandstone and mudstone (Izumi Group). Field evidence suggests that rainwater penetrated into permeable weathered sandstone layer lying on poor permeable mudstone layer. Many slope failures occurred at weathered sandstone layer because of low strength and a rise in the groundwater level. The occurrences of slope failures were controlled by weathered profile of alternating beds of sandstone and mudstone

Proceeding of The International Seminar on Chemistry

Abstract Currently, most of the biodiesel is produced from vegetable oils and methanol in the presence of base catalysts using mechanical stirring method at temperature 50-65 o C. This method consumes much energy because oils and methanol must be heated up to desired temperature, and also requires rather long reaction time. Ultrasound-assisted reaction can reduce the reaction time much shorter than mechanical stirring and the reaction can be carried out at room temperature, so energy can be saved. In the pilot scale the trans-esterification was performed by circulation process under low frequency ultrasound (20 kHz) with the input capacity of 1 kW. Effect of various process parameters such as the amount of KOH, molar ratio of oil to methanol and also reaction time were investigated. The optimal conditions for the process were: oil/methanol molar ratio 1:5, the amount of KOH to oil 0.7 % w/w. Under these conditions, conversion of triglycerides to fatty acid methyl esters (FAMEs) was 96.3% within the reaction time 60 minutes . Glycerin, catalyst and excess methanol were separated easily from FAMEs phase. Crude biodiesel was purified by washing with tap water and drying at 65 o C under reduced pressure at 520torr

Isolation and characterization of thermotolerant bacterium utilizing ammonium and nitrate ions under aerobic conditions

好気条件下で、アンモニアと硝酸塩を同時に除去する耐熱性菌を分離した。本菌は30C及び50Cにおいて両窒素化合物を効率的に除した。また、それらの代謝経路を明らかにした

Development of catheter-type tactile sensor composed of polyvinylidene fluoride (PVDF) film

To achieve quantitative palpation in vivo, we developed a catheter-type tactile sensor composed of a polyvinylidene fluoride film for minimally invasive surgery. We evaluated the fundamental performance of the prototype sensor by a weight-drop test. We also measured the output of the prototype sensor as it was inserted into a blood vessel model with shapes mimicking lesions. The ø2-mm sensor passed easily into the blood vessel model with lesion-like shapes. Sensor outputs corresponded to the shape of the inner wall of the blood vessel model, making it possible to determine the position of a protrusion and the convexity interval of a rough surface by filtering and frequency analysis of the output

The effect of depressive mood on the specificity of autobiographical memories in non-clinical individuals

This research investigated whether depressive subjects in non-clinical groups show an overgenerality of autobiographical memories, using the cued recall technique, and whether a distraction task affects the content of episodes they recalled in experimental groups, and whether there are negative biases in depressive subjects in episodes recalled by neutral cue words. Undergraduate students were screened by SDS and matched with the tendency of self-focusing, and divided into four groups (high-depressive and low-depressive controls, high-depressive and low-depressive experimental groups). The measures were the ratio of overgeneral memories, the level of specific autobiographical memories (0-3), the ratio of memories they recalled, their response latency, and the emotionality of memories they recalled in response to neutral cue words. The distraction task was an origami-task. The results of this experiment were as follows: 1) The low-depressive control and high-depressive experimental groups recalled a significantly lower ratio of autobiographical memories, and a significantly higher ratio of overgeneral memories in response to negative cues than positive and neutral cue words. 2) But the high-depressive controls did not show any significant difference to low-depressive control in overgenerality of autobiographical memories. 3) There were no negative biases in depressive subjects. 4) The effect of distraction task was unclear. The result suggests that overgenerality is not state-dependant and is only found in people with a diagnosis of depression(Williams, 1995).本研究は、非臨床群を自己注目傾向の高低を考慮してSDSによりスクリーニングし、高うつ傾向統制群、低うつ傾向統制群、高うつ傾向実験群、低うつ傾向実験群の4群に分け、実験群では自己への注目を低減する気晴らし課題を用い、以下の3点を検討した。1) 高低うつ傾向群間に、再生された自伝的記憶のエピソード性、反応潜時、エピソードの有無率、過度に一般化された記憶の割合、エピソード内容の情動性に違いがあるかどうかを、単語手がかり法を用いて検討する。2) 高うつ傾向群に再生されたエピソードのネガティブ・バイアスがあるかどうかを、単語の種類によるエピソードの有無率および中立語に対する自伝的エピソードの情動性について検討した。3) 気晴らし課題の効果があるかどうかを検討する。実験の結果、以下のことが明らかになった。1) 低うつ傾向統制群は、肯定的情動語や中立語でエピソード性が高く過度に一般化された記憶の割合が低く、否定的情動語でエピソード性が低く過度に一般化された記憶の割合が高い傾向があった。高うつ傾向実験群は低うつ傾向統制群と同様の結果となった。しかし、高うつ傾向統制群でエピソード性が低く過度に一般化された記憶の割合が多いという結果は得られなかったことから、非臨床群の高うつ傾向の被験者では過度に一般化された記憶は示されなかったと考えられる。これは、Williams (1999)の過度に一般化された記憶を示すのは認知スタイルの特徴であり特性的なものであるという仮説を支持する。2) 低うつ傾向群においては気分一致効果が見られたが、高うつ傾向群におけるネガティブ・バイアスは見られなかった。3) 気晴らし課題の効果は明確ではなかった。4) 反応潜時に差はなかった