Measurements of Stellar Inclinations for Kepler Planet Candidates II: Candidate Spin-Orbit Misalignments in Single and Multiple-Transiting Systems

We present a test for spin-orbit alignment for the host stars of 25 candidate planetary systems detected by the {\it Kepler} spacecraft. The inclination angle of each star's rotation axis was estimated from its rotation period, rotational line broadening, and radius. The rotation periods were determined using the {\it Kepler} photometric time series. The rotational line broadening was determined from high-resolution optical spectra with Subaru/HDS. Those same spectra were used to determine the star's photospheric parameters (effective temperature, surface gravity, metallicity) which were then interpreted with stellar-evolutionary models to determine stellar radii. We combine the new sample with the 7 stars from our previous work on this subject, finding that the stars show a statistical tendency to have inclinations near 90$^\circ$, in alignment with the planetary orbits. Possible spin-orbit misalignments are seen in several systems, including three multiple-planet systems (KOI-304, 988, 2261). Ideally these systems should be scrutinized with complementary techniques---such as the Rossiter-McLaughlin effect, starspot-crossing anomalies or asteroseismology---but the measurements will be difficult owing to the relatively faint apparent magnitudes and small transit signals in these systems.Comment: 11 pages, 9 figures, accepted for publication in Ap

Shiga toxin activates p38 MAP kinase through cellular Ca2+ increase in Vero cells

AbstractWe examined whether the mitogen-activated protein kinase (MAPK) pathway is involved in Shiga toxin (Stx)-induced Vero cell injury. Consonant with cell injury, Stx caused a transient extracellular signal-regulated kinase1/2 (ERK1/2) and a sustained p38 MAPK phosphorylation. p38 MAPK inhibitors (SB 203580 and PD 169316), but not an ERK1/2 kinase inhibitor (PD 98059), partially inhibited the Stx-induced cell death. BAPTA-AM, a Ca2+ chelator, reduced both cell injury and p38 MAPK phosphorylation. Antioxidants reduced Stx1-induced p38 MAPK phosphorylation. These data indicate that Stx activates p38 MAPK through an increase in intracellular Ca2+ and reactive oxygen species, and this signaling is involved in Stx-induced cell death

An energy landscape approach to understanding variety and robustness in tissue morphogenesis

During morphogenesis in development, multicellular tissues deform by mechanical forces induced by spatiotemporally regulated cellular activities, such as cell proliferation and constriction. Various morphologies are formed because of various spatiotemporal combinations and sequences of multicellular activities. Despite its potential to variations, morphogenesis is a surprisingly robust process, in which qualitatively similar morphologies are reproducibly formed even under spatiotemporal fluctuation of multicellular activities. To understand these essential characteristics of tissue morphogenesis, which involves the coexistence of various morphologies and robustness of the morphogenetic process, in this study, we propose a novel approach to capture the overall view of morphogenesis from mechanical viewpoints. This approach will enable visualization of the energy landscape, which includes morphogenetic processes induced by admissible histories of cellular activities. This approach was applied to investigate the morphogenesis of a sheet-like tissue with curvature, where it deformed to a concave or convex morphology depending on the history of growth and constriction. Qualitatively different morphologies were produced by bifurcation of the valley in the energy landscape. The depth and steepness of the valley near the stable states represented the degree of robustness to fluctuations of multicellular activities. Furthermore, as a realistic example, we showed an application of this approach to luminal folding observed in the initial stage of intestinal villus formation. This approach will be helpful to understand the mechanism of how various morphologies are formed and how tissues reproducibly achieve specific morphologies

Formation and characterization of phthalocyanine dimer/C60 solar cells

AbstractOrganic solar cells with μ-oxo-bridged gallium phthalocyanine dimer (GaPc dimer) and fullerene were produced by an evaporation method. A device based on the GaPc dimer provided a conversion efficiency of 4.2×10–3%, which is better compared to a device based on phthalocyanine monomer. Dimerization effect was discussed with a molecular orbital calculation, and the crystalline phases of the present solar cells were investigated by X-ray diffraction. Further improvement of the efficiency was discussed on the basis of the experimental results