肝障害における糖代謝異常に関する実験的研究-とくに慢性肝障害イヌにおける血中インスリンならびに血中グルカゴン動態よりの解明-

金沢大学医学部研究課題/領域番号:X00210----977136, 研究期間(年度):1974出典：「肝障害における糖代謝異常に関する実験的研究-とくに慢性肝障害イヌにおける血中インスリンならびに血中グルカゴン動態よりの解明-」研究成果報告書　課題番号：X00210----977136（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） （https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-X00210----977136/）を加工して作

Reasons for the delays in the definitive diagnosis of lung cancer for more than one year from the recognition of abnormal chest shadows

金沢大学医薬保健研究域医学系Objective. Primary lung cancer generally has a poor prognosis if not diagnosed at an early stage. But some lung cancers grow very slowly. In particular, adenocarcinoma is sometimes observed for years with no change of tumor size. In this study, we examined the reasons for the delays in reaching a definitive diagnosis of lung cancer. Methods. We retrospectively reviewed primary lung cancer cases between January 1995 and December 1999 and examined those whose definitive diagnoses were delayed for more than a year. Results. A total of 222 primary lung cancers were diagnosed. Of those, 19 patients (group A, 8.6%) were diagnosed after more than a year, and the other 203 (group B, 91.4%) were diagnosed within one year. The proportion of women in group A was significantly higher than that in group B (p<0.05). The mean age of group A was significantly younger than that of group B (p<0.05). The Brinkman Index of group A was significantly lower than that of group B (p<0.05). The histologic types were significantly different between the two groups (p<0.05). In group A, 18 patients (94.7%) had adenocarcinomas. Five primary reasons for the delays in group A were identified: 1) Four patients were tentatively diagnosed as inflammation or benign tumor on CT and were consequently not followed-up. 2) The chest CT shadows in 6 patients were suspected lung cancers but transbronchial lung biopsy findings did not show malignancy. 3) Four patients were tentatively diagnosed as inflammation or benign tumor on CT, but the tumors showed only very slow growth or no change at all. 4) The chest CT shadows of 2 patients were suspected lung cancer, but the patients refused to undergo video-assisted thoracic surgery (VATS) or closer examination. 5) Three patients did not consult medical facilities for a second examination. Conclusions. Many of the adenocarcinomas reviewed in our study grew slowly or remained unchanged for years. Doctors are mainly responsible for the delays in the definitive diagnosis and should aggressively perform VATS or closer examinations without hesitation

The DAWN Youth WebTalk Study: Methods, findings, and implications

It has long been understood that psychosocial issues are important to an understanding of diabetes among young people. The diagnosis and management of diabetes places a substantial burden on youths and their families. This burden may disrupt normal developmental processes, and can have a major impact on psychosocial adjustment and successful disease management. The multinational DAWN Study was a pioneering effort to identify psychosocial barriers to optimal health and quality of life of people with diabetes and new ways to overcome those barriers. The DAWN Study interviewed more than 5000 adults with diabetes and almost 4000 diabetes care professionals, but did not include children and young people with diabetes, their families, or their care providers because it was recognized that diabetes in young people presents different psychosocial issues and challenges than diabetes in adults, and that a separate study would be required to identify opportunities to improve outcomes among young people with diabetes and their families. This realization gave rise to theDAWNYouth WebTalk Study. The objectives of this study were to: • gain understanding of the challenges and issues facing young people with diabetes and those with responsibility for supporting them; • identify new avenues for improving the psychosocial management of diabetes among young people; • stimulate new efforts to improve care for young people with diabetes and their families. This paper presents an initial overview of the methods and findings of theDAWNYouthWebTalk Study and discusses some of the implications of those findings