5,518 research outputs found
Pressure-induced enhancement of superconductivity and superconducting-superconducting transition in CaC
We measured the electrical resistivity, , of superconducting
CaC at ambient and high pressure up to 16 GPa. For 8 GPa, we found
a large increase of with pressure from 11.5 up to 15.1 K. At 8 GPa,
drops and levels off at 5 K above 10 GPa. Correspondingly, the residual
increases by 200 times and the behavior
becomes flat. The recovery of the pristine behavior after depressurization is
suggestive of a phase transition at 8 GPa between two superconducting phases
with good and bad metallic properties, the latter with a lower and more
static disorder
Heart Failure Phenotypes Induced by Knockdown of DAPIT in Zebrafish: A New Insight into Mechanism of Dilated Cardiomyopathy
13301甲第4675号博士(医学)金沢大学博士論文要旨Abstract 以下に掲載:Scientific Reports 7(1) pp.17417 2017. Nature Publishing Group. 共著者:Nagata Y, Yamagishi M, Konno T, Nakanishi C, Asano Y, Ito S, Nakajima Y, Seguchi O, Fujino N, Kawashiri MA, Takashima S, Kitakaze M, Hayashi K
High compression strength single network hydrogels with pillar[5]arene junction points
The present study highlights a straightforward and versatile strategy for the synthesis of strong poly(2-isopropenyl-2-oxazoline) hydrogels with tunable properties by using a bifunctional macrocyclic pillar[5]arene host having two carboxylic acid groups as cross-linker. This new strategy provides access to materials with tailored properties from soft and flexible to rigid and strong. The mechanical properties and water uptake of the hydrogels could be effortlessly controlled during the synthesis step through variation of the cross-linker content and after cross-linking by guest-host interactions. The hydrogels displayed strongly enhanced mechanical properties (i.e., compression and tensile modulus, energy dissipation, stress at break and storage modulus) compared to their counterparts cross-linked with linear dicarboxylic acids. The remarkable properties of the pillar[5]arene cross-linked hydrogels were assigned to the transfer of the external stress to the rigid and bulky pillar[5]arene residues that contribute to the overall dimensional stability of the hydrogels and allow energy dissipation. Moreover, we demonstrate the applicability of these materials for water purification. The hydrogels showed high adsorption performance for phenols and dyes such as methylene blue and methyl red and they could be easily regenerated, by washing with an organic solvent for reuse
Intestinal stem cell proliferation and epithelial homeostasis in the adult Drosophila midgut
Adult tissue homeostasis requires a tight balance between the removal of old or damaged cells and the production of new ones. Such processes are usually driven by dedicated stem cells that reside within specific tissue locations or niches.
The intestinal epithelium has a remarkable regenerative capacity, which has made it a prime paradigm for the study of stem cell-driven tissue self-renewal. The discovery of the presence of stem cells in the adult midgut of the fruit fly Drosophila melanogaster has significantly impacted our understanding of the role of stem cells in intestinal homeostasis. Here we will review the current knowledge of the main mechanisms involved in the regulation of tissue homeostasis in the adult Drosophila midgut, with a focus on the role of stem cells in this process. We will also discuss processes involving acute or chronic disruption of normal intestinal homeostasis such as damage-induced regeneration and ageing
Fulde-Ferrell-Larkin-Ovchinnikov phase in the presence of pair hopping interaction
The recent experimental support for the presence of the
Fulde-Ferrell-Larkin-Ovchinnikov (FFLO) phase in the CeCoIn5 directed the
attention towards the mechanisms responsible for this type of
superconductivity. We investigate the FFLO state in a model where
on--site/inter--site pairing coexists with repulsive pair hopping interaction.
The latter interaction is interesting in that it leads to pairing with nonzero
momentum of the Cooper pairs even in the absence of the external magnetic field
(the so-called eta-pairing). It turns out that depending on the strength of the
pair hopping interaction the magnetic field can induce one of two types of the
FFLO phase with different spatial modulations of the order parameter. It is
argued that the properties of the FFLO phase may give information about the
magnitude of the pair hopping interaction. We also show that eta-pairing and
d-wave superconductivity may coexist in the FFLO state. It holds true also for
superconductors which in the absence of magnetic field are of pure d-wave type.Comment: 16 pages, 8 figure
Disordered Fulde-Ferrel-Larkin-Ovchinnikov State in d-wave Superconductors
We study the Fulde-Ferrel-Larkin-Ovchinnikov (FFLO) superconducting state in
the disordered systems. We analyze the microscopic model, in which the d-wave
superconductivity is stabilized near the antiferromagnetic quantum critical
point, and investigate two kinds of disorder, namely, box disorder and point
disorder, on the basis of the Bogoliubov-deGennes (BdG) equation. The spatial
structure of modulated superconducting order parameter and the magnetic
properties in the disordered FFLO state are investigated. We point out the
possibility of "FFLO glass" state in the presence of strong point disorders,
which arises from the configurational degree of freedom of FFLO nodal plane.
The distribution function of local spin susceptibility is calculated and its
relation to the FFLO nodal plane is clarified. We discuss the NMR measurements
for CeCoIn_5.Comment: Submitted to New. J. Phys. a focus issue on "Superconductors with
Exotic Symmetries
Regulated Inositol‐Requiring Protein 1‐Dependent Decay as a Mechanism of Corin RNA and Protein Deficiency in Advanced Human Systolic Heart Failure
BACKGROUND: The compensatory actions of the endogenous natriuretic peptide system require adequate processing of natriuretic peptide pro‐hormones into biologically active, carboxyl‐terminal fragments. Natriuretic peptide pro‐peptide processing is accomplished by corin, a transmembrane serine protease expressed by cardiomyocytes. Brain natriuretic peptide (BNP) processing is inadequate in advanced heart failure and is independently associated with adverse outcomes; however, the molecular mechanisms causing impaired BNP processing are not understood. We hypothesized that the development of endoplasmic reticulum stress in cardiomyocytes in advanced heart failure triggers inositol‐requiring protein 1 (IRE1)‐dependent corin mRNA decay, which would favor a molecular substrate favoring impaired natriuretic peptide pro‐peptide processing. METHODS AND RESULTS: Two independent samples of hearts obtained from patients with advanced heart failure at transplant demonstrated that corin RNA was reduced as Atrial natriuretic peptide (ANP)/BNP RNA increased. Increases in spliced X‐box protein 1, a marker for IRE1‐endoribonuclease activity, were associated with decreased corin RNA. Moreover, ≈50% of the hearts demonstrated significant reductions in corin RNA and protein as compared to the nonfailing control sample. In vitro experiments demonstrated that induction of endoplasmic reticulum stress in cultured cardiomyocytes with thapsigargin activated IRE1s endoribonuclease activity and time‐dependent reductions in corin mRNA. In HL‐1 cells, overexpression of IRE1 activated IRE1 endoribonuclease activity and caused corin mRNA decay, whereas IRE1‐RNA interference with shRNA attenuated corin mRNA decay after induction of endoplasmic reticulum stress with thapsigargin. Pre‐treatment of cells with Actinomycin D to inhibit transcription did not alter the magnitude or time course of thapsigargin‐induced corin mRNA decline, supporting the hypothesis that this was the result of IRE1‐mediated corin mRNA degradation. CONCLUSIONS: These data support the hypothesis that endoplasmic reticulum stress‐mediated, IRE1‐dependent targeted corin mRNA decay is a mechanism leading to corin mRNA resulting in corresponding corin protein deficiency may contribute to the pathophysiology of impaired natriuretic peptide pro‐hormone processing in humans processing in humans with advanced systolic heart failure
Andreev Bound States in High Temperature Superconductors
Andreev bound states (ABS) at the surface of superconductors are expected for
any pair potential showing a sign change in different k-directions with their
spectral weight depending on the relative orientation of the surface and the
pair potential. We report on the observation of ABS in HTS employing tunneling
spectroscopy on bicrystal grain boundary Josephson junctions (GBJs). The
tunneling spectra were studied as a function of temperature and applied
magnetic field. The tunneling spectra of GBJ formed by YBCO, BSCCO, and LSCO
show a pronounced zero bias conductance peak that can be interpreted in terms
of Andreev bound states at zero energy that are expected at the surface of HTS
having a d-wave symmetry of the order parameter. In contrast, for the most
likely s-wave HTS NCCO no zero bias conductance peak was observed. Applying a
magnetic field results in a shift of spectral weight from zero to finite
energy. This shift is found to depend nonlinearly on the applied magnetic
field. Further consequences of the Andreev bound states are discussed and
experimental evidence for anomalous Meissner currents is presented.Comment: 17 pages, 10 figures, to appear in Eur. Phys. J.
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