291 research outputs found
Efficacy of SSEA-3 Positive Cells Derived from Synovial Tissue in Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a refractory systemic autoimmune disease with chronic synovial inflammation. Sustained synovial inflammation leads to progressive destruction of bone and cartilage. Treatment to restore joints that have been destroyed irreversibly is not to be established yet even with the recent development of antirheumatic drugs and biological agents. Stage-specific embryonic antigen-3 (SSEA-3), a marker of human embryonic stem (ES) cell, acts as stem cells in the blood. SSEA-3 positive cells derived from RA synovial tissue have higher differentiating abilities than that of SSEA-3 negative cells and inhibitory effects on arthritis in collagen antibody-induced arthritis mice study. SSEA-3 positive cells derived from RA synovial tissue might have the inhibitory effect on arthritis and would be one of the cell sources for new RA treatment. The present manuscript is a brief review of mesenchymal stem cells in RA and described with the potential of RA cell therapy by SSEA-3 positive cells based on our research
Histopathological Change of Esophagus Related to Dysphagia in Mixed Connective Tissue Disease
Simple Method Using Gelatin-Coated Film for Comprehensively Assaying Gelatinase Activity in Synovial Fluid
Compressor with Turning-Paired Vane and Piston
With the aim of energy saving of room air conditioners, we are addressing higher efficiency of the rotary compressor that is used most in the world. We focused on a new rotary compressor equipped with a mechanism to restrict the rolling motion of the piston, and performed the dynamics analysis. The new rotary compressor has a small pillar at the tip of the vane and constitutes a turning pair of vane and piston, and it limits the rolling motion of the piston. By means of limiting the piston rotation, the heat transfer to the suction process from the compression chamber will be suppressed, and we can expect higher compression efficiency. Before examining the compression efficiency, we performed the dynamics analysis of this new rotary compressor and examined the forces and dynamic behavior of the components, and the mechanical efficiency of the compressor. Then we have following results. (1)We can clarify the contact point between the vane tip and piston in the turning pair by considering the equilibrium of forces and moments acting on the vane. (2)By reducing the diameter of the pillar at the vane tip, the vane tip friction loss is reduced, and the mechanical efficiency is improved. (3)The new rotary compressor has less vane tip friction loss and on the other hand greater friction loss between the vane side and the cylinder in comparison to the rolling piston rotary compressors. As a result, both compressors have almost the same mechanical efficiency
A Case of Mucosal Cancer of the Stomach Treated by Endoscopic Submucosal Dissection after Which Nodal Metastasis Became Evident
An 82-year-old male was referred to our institution for evaluation and treatment of a
protruding lesion in the stomach. Esophagogastroduodenoscopy (EGD) showed a small
protruding lesion and a large superficial elevated lesion on the lesser curvature of the
stomach (macroscopic type: 0-I and 0-IIa, resp.). CT and endoscopic
ultrasonography (EUS) visualized a small round lymph node (LN) 11 mm in size near
the lesser curvature, although submucosal invasion was not evident. These two lesions
were resected en bloc by endoscopic submucosal dissection (ESD). Pathological
examination of the resected specimen showed moderately differentiated tubular
adenocarcinoma (tub2) and well-differentiated tubular adenocarcinoma (tub1),
respectively, which were limited to the mucosal layer. Because lymphatic-vascular
involvement was not detected by hematoxylin and eosin (HE) staining, additional
gastrectomy was not performed. Two months after ESD, follow-up EUS and CT showed
an enlarged LN. EUS-guided fine needle aspiration (EUS-FNA) for the LN revealed
metastasis. Therefore, total gastrectomy with LN dissection was performed. His
postoperative course was uneventful. After discharge, he has been followed up at the
outpatient department without any sign of recurrence for 5 years. Histological
reexamination of the ESD specimen using immunohistochemistry showed lymphatic
invasion of cancer cells in the lamina propria of the 0-I lesion 13 mm in size
New coronary aneurysm formation and malapposition after zotarolimus-eluting stent implantation in Kawasaki disease
AbstractCoronary artery involvement is the most important complication of Kawasaki disease. Coronary artery bypass surgery has been performed for ischemic heart disease caused by Kawasaki disease, however, long-term coronary graft patency is not satisfactory. Therefore, percutaneous coronary intervention (PCI) has its role in Kawasaki disease-related coronary artery disease. The incidence of new aneurysm is lower following stent implantation than balloon dilatation alone, even if a higher balloon pressure is applied. However, there are few reports about the efficacy of drug-eluting stent implantation for Kawasaki disease with coronary artery disease. Here, we describe a case of new coronary aneurysm formation and malapposition after zotarolimus-eluting stent implantation in Kawasaki disease.<Learning objective: New aneurysm formation after balloon angioplasty for coronary artery lesions in Kawasaki disease is a relatively well-known phenomenon, however there have been no reports about the influence of drug-eluting stents for coronary artery disease with Kawasaki disease. This report is useful when we consider strategies of revascularization for coronary artery disease with Kawasaki disease.
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