模擬微小重力培養は外傷性脳損傷におけるヒト頭蓋骨由来間葉系幹細胞の神経保護効果を高める

内容の要旨, 審査の要旨広島大学(Hiroshima University)博士(保健学)Doctor of Philosophy in Health Sciencedoctora

Minority-carrier diffusion length, minority-carrier lifetime, and photoresponsivity of β-FeSi2 layers grown by molecular-beam epitaxy

We have epitaxially grown undoped β-FeSi2 films on Si(111) substrates via atomic-hydrogen-assisted molecular-beam epitaxy. β-FeSi2 films grown without atomic hydrogen exhibited p-type conduction with a hole density of over 1019 cm−3 at room temperature (RT). In contrast, those prepared with atomic hydrogen showed n-type conduction and had a residual electron density that was more than two orders of magnitude lower than the hole density of films grown without atomic hydrogen (of the order of 1016 cm−3 at RT). The minority-carrier diffusion length was estimated to be approximately 16 μm using an electron-beam-induced current technique; this value is twice as large as that for β-FeSi2 prepared without atomic hydrogen. This result could be well explained in terms of the minority-carrier lifetimes measured by a microwave photoconductance decay technique. The 1/e decay time using a 904 nm laser pulse was approximately 17 μs, which is much longer than that for β-FeSi2 prepared without atomic hydrogen (3 μs). The photoresponsivity reached 13 mA/W at 1.31 μm, which is the highest value ever reported for β-FeSi2 films

ショウチョウカンマク シボウ ニクシュ ノ 1レイ

We report a case of small intestinal mesenteric liposarcoma. An ８４-year-old woman was admitted to our hospital with a chief complaint of abdominal distension and pointing out a tumor in her abdomen. On physical examination an adult’s head-sized tumor was palpated from the left upper portion of the pelvis. Abdominal computed tomography（CT）revealed the mass２４×１８×１３cm in size which had clear borderline and smooth surface. Multi-detector-CT scan revealed a heterogeneously enhanced mass fed by the Superior mesenteric artery. With a clinical diagnosis of liposarcoma arisen from the small intestinal mesentery, the patient was operated on. The tumor was present in the mesentery of the small intestine and a removal of the tumor with associated resection of the small intestine was perfomed. The histological diagnosis was well-differentiated liposarcoma. The patient has been followed for nine months after the operation without evidence of local recurrence

Screening of radiation susceptibility genes by single-nucleotide polymorphisms and haplotype analysis

Radiotherapy for breast cancer patients occasionally induces adverse effects. The adverse reactions to radiotherapy are caused by multiple factors, including individual genetic differences. The heterogeneity in normal tissue reactions may result from the combined effect of several different genetic alterations. Single nucleotide polymorphisms (SNPs) and derived haplotypes within multiple genes may be used to detect the genetic alterations related to the heterogeneity in normal tissue reactions. DNA was sampled from 397 Japanese breast cancer patients who qualified for breast-conserving radiotherapy. Using the NCI-CTC scoring system version 2, the patients were grouped according to adverse skin reactions at 3 months of starting radiotherapy (grade = 0, n = 230; grade &#8805; 1, n = 167). Nine hundred and ninety-nine SNPs from 137 candidate genes for radiation susceptibility were genotyped, and haplotype associations between groups were assessed. Global haplotype association analysis (P < 0.05 and FDR < 0.005) indicated that estimated haplotypes in three loci were associated with the risk of adverse skin reactions. Comparison of risk haplotype to the most frequent haplotype in each locus showed haplotype CGATA(OR = 2.04; 95% CI, 1.19-3.52) and TGATG(OR = 5.05; 95% CI, 1.31-19.53) and TGAGG(OR = 12.89; 95% CI, 1.53-108.25) in TGFBI , CT in IL1A (OR = 1.83; 95% CI, 1.17-2.85), and AGT in GSTA4 (OR = 2.77; 95% CI, 1.23-6.22) had significantly greater adverse skin reactions risk.In conclusion, Individual radiosensitivity may be partly determined by combinations of these haplotypes in multiple loci. This would provide an understanding of the mechanisms underlying the genetic variation in radiation sensitivity or resistance among the population, and would show the possibility of prediction of the risk of adverse skin reactions prior to radiation therapy.10th Anniversary of Kazusa Arc International Symposium on Advanced Functional Genomic