Petrological feature of spinel lherzolite xenolith from Oki-Dogo Island: An implication for variety of the upper mantle peridotite beneath southwestern Japan

Spinel lherzolite is a minor component of the deep-seated xenolith suite in the Oki-Dogo alkaline basalts, whereas other types of ultramafic (e.g. pyroxenite and dunite) and mafic (e.g. granulite and gabbro) xenoliths are abundant. All spinel lherzolite xenoliths have spinel with a low Cr number (Cr#; 89), and are rarely associated with Fe-rich cumulus mafic and ultramafic xenoliths. This indicates that the LREE-enrichment in mantle rocks has been more prominent and prevalent than Fe and other major-element enrichment during the metasomatism

Aging-related Characteristics of Subclinical Hypothyroidism Detected in General Practice

Subclinical hypothyroidism (SCH) is diagnosed when serum thyrotropin (TSH) is elevated despite a normal thyroxine level and is known to increase the risk of metabolic disorders. This study was conducted to identify potential laboratory markers suspicious for latent SCH. We retrospectively reviewed 958 outpatients in whom thyroid functions had been examined. Eighty-five (9.1%) of the 939 analyzed subjects had SCH (73% females). In the SCH group, median serum TSH and FT4 levels were 5.04 μU/ml and 1.19 ng/dl, respectively, and auto-thyroid antibodies were detected in 53.8% of patients. SCH group patients were significantly older than patients in the euthyroid group, while there was no intergroup difference in BMI. However, 56.5% of the SCH patients were asymptomatic. In the SCH group, serum aspartate aminotransferase and low-density lipoprotein cholesterol (LDL-C) levels were significantly higher, and the estimated glomerular filtration rate (eGFR) was significantly lower than in the euthyroid group. Among patients less than 65 years of age, SCH patients tended to have lower eGFR and higher LDL-C than euthyroid patients. Age-dependent reductions of red blood cells and serum albumin were more prominent in the SCH than the euthyroid group. Biochemical changes with aging are useful as potential clues for suspecting latent SCH

Serum levels of 1,25-dihydroxyvitamin D, 24,25-dihydroxyvitamin D, and 25-hydroxyvitamin D in nondialyzed patients with chronic renal failure

Serum levels of 1,25-dihydroxyvitamin D, 24,25-dihydroxyvitamin D, and 25-hydroxyvitamin D in nondialyzed patients with chronic renal failure.BackgroundIn patients with chronic renal failure (CRF), abnormalities in vitamin D metabolism are known to be present, and several factors could contribute to the abnormalities.MethodsWe measured serum levels of three vitamin D metabolites, 1,25(OH)2D, 24,25(OH)2D and 25(OH)D, and analyzed factors affecting their levels in 76 nondialyzed patients with CRF (serum creatinine> 1.6 and < 9.0 mg/dl), 37 of whom had diabetes mellitus (DM-CRF) and 39 of whom were nondiabetic (nonDM-CRF).ResultsSerum levels of 1,25(OH)2D were positively correlated with estimated creatinine clearance (CCr; r = 0.429; P < 0.0001), and levels of 24,25(OH)2D were weakly correlated with CCr (r = 0.252, P < 0.05); no correlation was noted for 25(OH)D. Serum levels of all three vitamin D metabolites were significantly and positively correlated with serum albumin. Although there were no significant differences in age, sex, estimated CCr, calcium and phosphate between DM-CRF and nonDM-CRF, all three vitamin D metabolites were significantly lower in DM-CRF than in nonDM-CRF. To analyze factors influencing vitamin D metabolite levels, we performed multiple regression analyses. Serum 25(OH)D levels were significantly and independently associated with serum albumin, presence of DM and serum phosphate (R2 = 0.599; P < 0.0001). 24,25(OH)2D levels were significantly and strongly associated with 25(OH)D (β; = 0.772; R2 = 0.446; P < 0.0001). Serum 1,25(OH)2D levels were significantly associated only with estimated CCr (R2 = 0.409; P < 0.0001).ConclusionsThese results suggest that hypoalbuminemia and the presence of DM independently affect serum 25(OH)D levels, probably via diabetic nephropathy and poor nutritional status associated with diabetes, and that 25(OH)D is actively catalyzed to 24,25(OH)2D in CRF, probably largely via extrarenal 24-hydroxylase. Serum levels of 1,25(OH)2D were significantly affected by the degree of renal failure. Thus, this study indicates that patients with CRF, particularly those with DM, should receive supplements containing the active form of vitamin D prior to dialysis

Titanium peroxide nanoparticles enhanced cytotoxic effects of X-ray irradiation against pancreatic cancer model through reactive oxygen species generation in vitro and in vivo

Details of the synthetic protocol for PAA-TiOxNPs formation from TiO2NPs. (PPTX 151 kb

Experimental Evaluation of Effects of Intra-Aortic Balloon Pumping (IABP) on Ischemic Heart

The intraaortic balloon pumping (IABP) has been widely empoyed in the management of ventricular power failure. The effects of IABP were studied in a large number of reports. However, the efficacy of IABP has not been certified with reference to the severity of myocardial ischemia. Experimentally augmentation of coronary blood flow were observed on acute ischemic heart by ligation of the anterior descending artery. It has shown from the view of increased coronary blood flow that excess of 50ml/min/kg of coronary blood flow were obtained in functional reserved myocardium with ischemia. However, the efficacy of IABP on acute ischemic heart can not be precipitated by severe damage of the myocardium. The usefulness of IABP was elucidated by functional myocardial level of at least 50mmHg of LVP, 40mmHg of LVEDP and 1000mmHg/sec of max dp/dt respectivelly and it is emphasized that immediate application of IABP for cardiogenic shock allows to improve the further myocardial depression

An Experimental Functional Evaluation of End to Side Anastomosis Related to Operative Procedures of Tracheobronchial Reconstruciotn

End to side anastomosis between the trachea and the bronchus was widely employed as one of bronchial reconstructed method. However, functional evaluation undergone bronchial reconstruction did not completely display its superiority functionally. This study was undertaken to determine whether end to side anastomosis was far superior in regard to reserved pulmonary function by means of observation on changes in size of anastomotic area on xp film delineated during inspiration and exspiration simultaneously and also by intrabronchial pressure tracing. The results were as follows. 1) The creation of window defect on the tracheal wall prior to anastomosis was necessary to maintain an adequate anastomotic area. 2) The end to side anastomosis obliquely results in an excellent ventilation functionally. In contrast, the ill effects were disclosed by moderate angulation as far as exceeded 45 degree against tracheal wall owing to loss of rigidity in bronchial wall. From the present study, we concluded that end to side anastomosis obliquely with moderate degree should be avoided because of bronchial stenosis produced by bronchial collapse due to loss of supporting ability of bronchial cartilage

血清ペプシノゲン検査に基づく胃がん発生率と有効性に関する15年間のコホート研究

Objectives : The incidence of and mortality from gastric cancer in Japan have remained high and prophylaxis is important. However, the number of the individuals undergoing gastric mass radiography has decreased in recent years because the examination has a big burden at the time of the consultation. Many studies have reported the ease and effectiveness of the pepsinogen test and a higher incidence of gastric cancer in positive groups. However, the longest survey period was 10 years. Therefore, we conducted a 15-year cohort study to examine the validity of the testing period and the incidence of gastric cancer in serum pepsinogen positive and negative groups at a private company utilizing pepsinogen test. Methods : Subjects were 4383 employees who received a pepsinogen test. Subjects were followed for 15 years. For the purpose of examining the three periods over five-, 10-, and 15-year periods, we analyzed the validity of testing during each period, carried out a log-rank test, and analyzed hazard ratio in the Cox proportional hazard model. Results : The number of individuals who developed gastric cancer during the survey was nine in the five-year negative group, 18 in the five-year positive group, 16 in the 10-year negative group, 27 in the 10-year positive group, 31 in the 15-year negative group, and 29 in the 15-year positive group. The sensitivity of testing was 0.667 over the first five years, 0.628 over 10 years, and 0.483 over 15 years, and the specificity was 0.744 over the first five years, 0.745 over 10 years, and 0.745 over 15 years. The five-year incidence of gastric cancer was 57 per 100,000 person years in the negative group and 350 per 100,000 person years in the positive group. The ten-year incidences were 53 per 100,000 person years in the negative group and 279 per 100,000 person years in the positive group. The 15-year incidence was 75 per 100,000 person years in the negative group and 231 per 100,000 person years in the positive group. The hazard ratio of the positive group toward the negative group was 4.98 over the first five years, 4.71 over 10 years, and 2.76 over 15 years (p＜0.001). Conclusions : This study clarified that the first five years after the testing showed the highest hazard ratio and validity, therefore, the validity of testing was approximately 10 years. 【目的】我が国の胃がんの死亡率及び罹患率は現在も上位であり、その予防対策は重要で ある。けれども、近年X線の胃集団検診の受診者は、受診時の負担が大きいことから減少 している。一方職域の胃がん予防対策は、法的義務が無いため、企業により様々であるが 地域同様減少している。多くの先行研究では、血清ペプシノゲン検査法が簡便で有益とし ており、陽性群に発症率が高いとしているが、調査期間は最長10年であり、15年間の調査 はなかった。そこで、一企業において15年間の“陽性群”と“陰性群”での発症率の違い と検査の有効性の期間を検討することを目的にコホート調査を行った。 【方法】ペプシノゲン検査を受診した4,383名を15年間追跡した。５年間、10年間、15年間の ３期間に区切って各期間の検査の有効性を算出し、発症率をLog-rankで検定し、発症危険 度をCox比例ハザードで分析した。 【結果】追跡期間中に陰性群と陽性群のそれぞれの胃がん発症数は、５年間で９人と18人、 10年間で16人と27人、15年間で31人と29人であった。検査の感度は５年間で0.667、10年間 で0.628、15年間で0.483であり、特異度は、５年間で0.744、10年間で0.745，15年間で0.745 であった。発症率では、５年間の陰性群と陽性群で57、350per 100,000 person yearsであり、 10年では53、279 per 100,000 person years であり、15年では 75、231 per 100,000 person yearsであった。陰性群に対する陽性群の発生危険度は、５年間4.98、10年間4.71、15年間 2.76であった (p＜0.001)。 【結論】胃がんの発症率及び発症危険度や検査の有効性が最も高かったのは、2000年まで の５年間であり、検査の有効性は、約10年であることが明らかになった。Thesis of Takami Okuno / 奥野 敬生 博士論文 金沢大学医薬保健学総合研究科（保健学専攻

Clinical Evaluation of Immune Response in Patients with Cancer

Immune response was clinically evaluated in 25 patients with carcinoma compared with 26 of non cancer patients by means of lymphocyte transformation against PHA which was shown as stimulation index. In patients with cancer, stimulation index showed apparently as low as an average of 38 compared with 82 of non-cancer patients. Furthermore, the level of stimulation index was a corresponding correlation to age in which low activation was presented in the elderly. According to diseased organs, the weak response of stimulation index against PHA were observed in patients with the carcinoma of the esophagus and the lung. The response of skin test for PPD, PHA, SK-SD and candida were inhibited in patients with advanced cancer of stage III and IV compared with that of stage I and II. These responses were also suppressed in postoperative course until at least 6 months after surgery. From these results, it was noted that operative procedures provoked the induced weakness against host defense immunologically. However, it was certified that the use of immunopotentiator faciliated the activity of immune response during postoperative period for the patients with no severely advanced lung cancer of stage I and II despite of little effects for patients with advanced lung cancer of stage III and IV. It was concluded that immune response of patients with cancer was inhibited by advancing carcinoma and by operative procedures but the use of immunopotentiator was beneficial to promote the host defense during postoperative period

A Functional Evaluation of Bronchial Reconstructed Lung with Special Reference to Denervation

Bronchoplastic procedures for lung cancer were suitable operative method to reserve pulmonary function and to enlarge the resected area. However, functional evaluation is not necessarily achieved in bronchial reconstructed lung, especially with reference to denervation. In this study the influence of denervation was investigated experimentally by pulmonary perfused wedge method in which vascular tonus was directly illustrated and by measurement of oxygen saturation (Sao2) of pulmonary venous blood in which the ability of oxygen uptake was elucidated. When comparing the results of denervation with regard to operative procedures of bronchoplasty, bronchoplasty with sleeve anastomosis of pulmonary artery and autotransplantation respectively, the deteriorate effects related to bronchoplasty were not observed as compared to autotransplantation