ニュウヨウジ トノ ケイゾクテキ コウリュウ ジッシュウ オ クミイレタ タイケンガタ コミュニケーション ジュギョウ

現代の大学教育では、従来からの専門教育と共に、人間カをバランスよく育むことが求められて いる。対人援助を目的とする医療系学部において、その期待は特に強い。しかしその一方で現代社会は 人間関係が希薄になり、「人」が成長しにくくなっている。実際の教育現場においても学生の社会性の 欠如・人間性の未熟さを実感する場面が少なくない。徳島大学では文部科学省の補助金を得て、平成18年度後期より平成20年度まで、乳幼児との交流実習を取り入れたコミュニケーション授業を行った。その結果、乳幼児との継続的な交流実習が、座学の授業や学生同士のロールプレイでは得ることが困難と思われる気づきや、高いモチベーションをもたらすことがわかっり、学生の人間性に働きかける教育法であることが示唆された。この有効性と効果について考察した

Identification of a Cytokine-induced Antiapoptotic Molecule Anamorsin Essential for Definitive Hematopoiesis

Many growth factors and cytokines prevent apoptosis. Using an expression cloning method, we identified a novel antiapoptotic molecule named Anamorsin, which does not show any homology to known apoptosis regulatory molecules such as Bcl-2 family, caspase family, or signal transduction molecules. The expression of Anamorsin was completely dependent on stimulation with growth factors such as interleukin 3, stem cell factor, and thrombopoietin in factor-dependent hematopoietic cell lines, and forced expression of Anamorsin conferred resistance to apoptosis caused by growth factor deprivation in vitro. Furthermore, Anamorsin was found to act as an antiapoptotic molecule in vivo because Anamorsin−/− mice die in late gestation due to defective definitive hematopoiesis in the fetal liver (FL). Although the number of hematopoietic stem/progenitor cells in the FL did not decrease in these mice, myeloid, and particularly erythroid colony formation in response to cytokines, was severely disrupted. Also, Anamorsin−/− erythroid cells initiated apoptosis during terminal maturation. As for the mechanism of Anamorsin-mediated cell survival, a microarray analysis revealed that the expression of Bcl-xL and Jak2 was severely impaired in the FL of Anamorsin−/− mice. Thus, Anamorsin is considered to be a necessary molecule for hematopoiesis that mediates antiapoptotic effects of various cytokines

Amelogenin Stimulates Bone Sialoprotein (BSP) Expression Through Fibroblast Growth Factor 2 Response Element and Transforming Growth Factorâ β1 Activation Element in the Promoter of the BSP Gene

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141420/1/jper1482.pd

Effects of Wellness Conscious Buildings on the Well-being and Comfort of Workers

In recent years, Mental and physical health of office workers is regarded as a problem and the office buildings which improve workers’ wellness. The WELL Building Standard was announced with the aim of improving the health condition of building users in 2014. The purpose of this study is to demonstrate the improvement of the health condition of the office workers who work at the office applying WELL Building Standard. To achieve this purpose, low-score office and high-score office for WELL Building Standard scores were created by changing the indoor environment and furniture in the office, and subject experiments in which we perform the work were conducted in each condition. From the experimental results, we propose environmental control and introduction furniture to verify changes in health condition of office workers, to improve the wellness of building users, and to bring synergy effects to health. It was confirmed that working at plural spaces which workers chose themselves

Enzyme-Linked Immunosorbent Assays with High Sensitivity for Antigen-Specific and Total Murine IgE: A Useful Tool for the Study of Allergies in Mouse Models

Background: In studies on allergies in mouse models, IgE production is an essential parameter to be evaluated. Here, we examine the effect of commercially available immunoreaction enhancer solutions and different blocking reagents in enzyme-linked immunosorbent assay (ELISA) for total or antigen-specific murine IgE in order to improve the assays. Methods: Sera from mice immunized with recombinant house dust mite major allergens, Der f 1 and Der p 1, were used for the assays. Total IgE was measured by sandwich ELISA using monoclonal antibodies against murine IgE. Antigen-specific IgE was assayed using allergen-coated plates. Sensitivity or signal intensity in ELISA was compared among conditions differing in the use of enhancer solutions, blocking reagents, or monoclonal antibodies, and incubation time. Results: Use of enhancer solutions improved the sensitivity of ELISA for total IgE by approximately 30-fold of that using a conventional buffer. A blocking reagent caused more unwanted enhancement of the background signal in blank wells in ELISA for total IgE compared with another blocking reagent, however, improved signal intensity in ELISA for antigen-specific ELISA without significant enhancement of the background signal. Optimal assay conditions were determined. Conclusions: Enhancer solutions are effective in improving ELISAs for total and antigen-specific murine IgE. Selection of blocking reagents was important to decrease unwanted enhancement of background signals and was effective in enhancing signals for positive samples. The ELISAs improved in this study are useful for the study of allergies in mouse models