Immunoglobulin Production by Peripheral Blood Mononuclear Cells in IgA Nephropathy Patients and their Relatives

Immunoglobulin production by peripheral blood mononuclear cells of 27 patients of IgA nephropathy and 11 relatives was determined. In comparison with 15 healthy controls, no significant difference could be observed in both IgA nephropathy patients and relatives of the group not stimulated with PWM, but in the group stimulated with PWM a significant elevation in the production of IgA, IgG and IgM was seen in IgA nephropathy patients, while in the relatives a significant elevation in production of IgA and IgG was observed. It is speculated that immune complexes mainly IgA are the chief cause of development and progression of IgA nephropathy and that IgG and IgM are also involved. In also relatives, the presence of immunological abnormalities similar to those of IgA nephropathy patients is suggested

発育性股関節形成不全への人工股関節置換術における寛骨臼コンポーネント設置に対するCT-basedナビゲーションシステムの有効性

Purpose: Developmental dysplasia of the hip (DDH) presents a considerable surgical challenge in total hip arthroplasty (THA). Although the usefulness of computed tomography (CT)-based navigation in cup alignment has been reported, few reports have evaluated three-dimensional (3-D) cup positioning against the acetabulum specifically in patients with DDH. The purpose of this study was to evaluate the efficacy of a CT-based navigation system for alignment and spatial positioning of the cup in THA for patients with DDH. Methods: We reviewed 174 DDH THA cases in which CT-based navigation was used, and 75 cases in which a mechanical guide was used as a control group. Postoperative cup alignment and spatial positioning were evaluated by superimposition of a 3-D cup template onto the actual implanted cup using postoperative CT images, with pelvic coordinates matching the preoperative planning. Results: The proportion within the combined target zone (inclination and anteversion) was 97.7% in the navigation group and 61.3% in the non-navigation group. The mean absolute error between the intraoperative record and the postoperative measurement was 1.5° ± 1.3° for inclination and 2.1° ± 1.8° for anteversion in the navigation group. For acetabular cup positioning, the mean discrepancy between the preoperative planning and the postoperative measurements was 1.9+1.6 mm on the transverse axis, 2.8 ± 2.3 mm on the longitudinal axis, and 1.7 ± 1.3 mm on the sagittal axis. Conclusion: THA using a CT-based navigation system achieved quite high accuracy of cup alignment angles and spatial cup positioning in primary THA for patients with DDH

A Huge Capital Drop with Compression of Femoral Vessels Associated with Hip Osteoarthritis

A capital drop is a type of osteophyte at the inferomedial portion of the femoral head commonly observed in hip osteoarthritis (OA), secondary to developmental dysplasia. Capital drop itself is typically asymptomatic; however, symptoms can appear secondary to impinge against the acetabulum or to irritation of the surrounding tissues, such as nerves, vessels, and tendons. We present here a case of unilateral leg edema in a patient with hip OA, caused by a huge bone mass occurring at the inferomedial portion of the femoral head that compressed the femoral vessels. We diagnosed this bone mass as a capital drop secondary to hip OA after confirming that the mass occurred at least after the age of 63 years based on a previous X-ray. We performed early resection and total hip arthroplasty since the patient’s hip pain was due to both advanced hip OA and compression of the femoral vessels; moreover, we aimed to prevent venous thrombosis secondary to vascular compression considering the advanced age and the potent risk of thrombosis in the patient. A large capital drop should be considered as a cause of vascular compression in cases of unilateral leg edema in OA patients

大学生の学園生活満足の分析(人文・社会科学篇)

The purpose of the present study was to investigate college life satisfaction of undergraduates of three colleges. Questionnaires were administered to 278 undergraduates. The results were that (a) through factor analysis, 15 factors in college life satisfaction were abstracted, (b) differences in factor score were found between three colleges. From the practical viewpoint, the present study reveals the need for improvement in learning surroundings and a curriculum

The Posterior Condylar Cartilage Affects Rotational Alignment of the Femoral Component in Varus Knee Osteoarthritis

Rotational alignment of the femoral component in total knee arthroplasty (TKA) is important for patellar tracking and ligament balance. Preoperative planning based on radiography might have a potential risk for over-rotation because these X-ray based measurements can not detect asymmetric cartilage wear on posterior condyle. The purpose of this study is to evaluate the effect of the posterior condylar cartilage of varus osteoarthritic knee on rotational alignment of the femoral component in TKA. We established two different condylar twist angles (CTA) from intraoperative multiplanar reconstruction (MPR) images and intraoperative information of navigation system. The CTA measured by a navigation system that includes the cartilage (4.8±2.0°) was smaller than those measured by MPR images, which does not include the cartilage (6.6±2.1°) (p<0.05). The difference between these two angles that corresponds to the remaining posterior condylar cartilage was 1.7±1.2°. This result demonstrated that the posterior condylar cartilage might lead to over-rotational of the femoral component in varus osteoarthritic knee. Therefore, when determining rotational alignment of the femoral component, surgeons should consider the effect of the remaining posterior condylar cartilage to avoid the over-rotation of the femoral component, especially in severe varus knees

Outcome of an elbow check-up system for child and adolescent baseball players

Purpose : Our aim was to examine the outcome of an elbow check-up system for youth baseball players. In particular, we investigated the nature of elbow injuries in youth baseball players with elbow pain and ultrasonographic findings of the capitellum. Materials and Methods : A total of 1605 players participating in the regional summer championship in July 2013 underwent a questionnaire survey, physical examination, ultrasound imaging, and radiographic examination. Results : A total of 499 (31.1%) players reported episodes of elbow pain, of whom 320 (64.1%) had abnormal findings on physical examination, and 115 (35.9%) agreed to undergo radiography. Among them, 98 (85.2%) exhibited radiographic abnormalities. On the initial ultrasonography screening, 60 (3.7%) players had an abnormal finding and 55 (91.7%) agreed to undergo radiography. Among them, 26 (47.3%) were found to have osteochondritis dissecans (OCD) of the capitellum on radiographs. Conclusions : About 30% of youth baseball players had episodes of elbow pain, and 64.1% of players with elbow pain had abnormal findings on physical examination. Furthermore, 85.2% of subjects who underwent radiographic examination exhibited radiographic abnormalities. About 4% of young baseball players had an abnormal finding on initial ultrasonography screening, and nearly 50% of them had OCD of the capitellum on radiographs

Arthroscopic excision of unstable os acromiale associated with impingement syndrome : a case report

Os acromiale is a rare anatomical variant that is caused by failure of fusion of the acromial apophysis and is usually asymptomatic. We report a case of impingement syndrome of the left shoulder secondary to unstable os acromiale, which was initially overlooked and confirmed only during arthroscopic examination. Arthroscopic excision of the unstable fragment was successful without residual dysfunction of the deltoid muscle

ミナマタシ ニ オケル チイキ ジュウミン ノ ケンコウ ジッタイ チョウサ : ケンコウ マツリ サンカシャ ノ データ オ トオシテ

The purpose of this research is to clarify health problems of the residents in Minamata City that faces two main health problems; of the prevention of metabolic syndrome(MS) and the nursing care prevention which are to be needed for the rapidly increasing home-care senior citizen

STUDIES ON PAIN SENSATIONS AND REACTIONS [1] : Apparatus and measurement of skin potential response(Cultural and Social science)

Hardyタイプの催痛刺激装置を改良し,キャリブレーションを行った。装置の概要,キャリブレーションの手続を概説し,実施した予備的実験結果を報告した。男子大学生20名を対象に,100mc/sec/cm^2, 200mc/sec/cm^2, 300mc/sec/cm^2の3刺激を用い,各刺激で5回,それぞれ"用意"の合図のあと3sec後に墨を塗布した右前腕部に照射した。痛知覚所要時間は,100mc/sec/cm^2で2.95sec, 200mc/sec/cm^2で1.45sec, 300mc/sec/cm^2で0.93secであった。同時に測定したSPRでは,試行が重ねられるにしたがって,"用意"に対する反射は小さくなるhabituationが観察された。又,刺激強度との対応では300mc/sec/cm^2に対する反射が最大であったが,残り2刺激に対しては明確な結果が得られなかった。Hardy type dolorimeter was modified and calibrated. With three stimuli varied in intensity (100mc./sec./cm., 200mc./sec./cm., and 300mc./sec./cm.), elapsed time from onset of thermal stimulus to perceiving pain sensation and skin potential responses (SPRs) were measured. The results show that elapsed time from onset of thermal stimulus to perceiving pain sensation is shorter than that of the previous data, mean amplitude of SPRs to signal "ready" decrease as a function of repetition of trial, and mean amplitude of SPRs is not correspondent with stimulus intensity