Health Support Provided by Yogo Teachers for Adolescent Female Students with a Thin Body Type

Purpose: To clarify the realities and challenges involved in health support provided by yogo teachers to adolescent girls who have a thin body type. Methods: A semi-structured interview survey was conducted with yogo teachers at a Japanese high school with experience of providing health support to thin adolescent female students and the results of the survey were subjected to qualitative analysis. Results: With regard to health support provided by yogo teachers, the results of analysis found that the actual situation consisted of the five categories of 【sharing information throughout the school organization to investigate methods of support】,【 realizing studentsʼ situations through the provision of individual support】, 【referring students and parents to specialist agencies】,【investigating collaborations with parents with students ʼ consent】, and 【carrying out prevention and awareness-raising activities about thin physiques】.　 However, the analysis also found that the practical challenges for providing such health support consisted of the six categories of 【working with parents to liaise with medical institutions】,【continuous support in collaboration with specialist agencies】,【 educational health support that enables all students to manage their own health】,【 yogo teachersʼ professional knowledge and assessment of eating disorders】,【 support methods that students can engage with on their own initiative, according to their situation】, and 【creating a counseling- friendly environment to facilitate early detection】.Discussion: While yogo teachers had an overall grasp of studentsʼ situations through their organizational engagements in cooperation with faculty and school physicians, as well as individual support activities, it was clear that they faced difficulties and challenges in relation to working together with parents and specialist agencies.　In the future, improving collaboration with parents will require that they, too, be encouraged to recognize that being excessively thin represents a health problem for adolescent female students.　In addition, it will also be necessary to work towards building daily collaboration systems, such as by having yogo teachers keep track of potential partner medical institutions as a matter of routine.　It was further suggested that yogo teachers will need to provide educational and preventive health support oriented toward helping female students acquire the ability to manage their own health

Factors explaining seasonal variation in energy intake: a review

Maintaining a balance between energy intake and expenditure is crucial for overall health. There are seasonal variations in energy intake, with an increase during spring and winter as well as a decrease during summer. These variations are related to a combination of environmental factors, including changes in temperature and daylight hours; social factors, including events and holidays; and physiological factors, including changes in physical activity and emotions. Accordingly, this review aimed to summarize the environmental, social, and physiological factors that contribute to seasonal variations in energy intake. A review of the current literature revealed that changes in temperature and daylight hours may affect eating behavior by altering homeostatic responses and appetite-related hormones. Additionally, increased participation in events and frequency of eating out, especially during winter vacations, may contribute to increased energy intake. Notably, these findings may not be generalisable to all populations since environmental and social factors can vary significantly depending on the local climatic zones and cultural backgrounds. The findings of the present review indicate that seasonal climate, events, and associated hormonal changes should be taken into account in order to maintain adequate energy intake throughout the year

Mental and physical effects of the 2011 Great East Japan Earthquake on School Children, and Health Support initiatives by YogoTeachers: Findings from a survey of high school yogo teachers 5 years after the disaster

Objective: To clarify the current mental and physical state of students 5 years after experiencing the Great East Japan earthquake, tsunami, and nuclear accident, and to shed light on the practical initiatives and issues faced by yogo teachers in supporting students’ health. Method: In May 2016, we conducted a mail-based questionnaire of yogo teachers at 15 prefectural high schools in Soma District and Futaba District (collectively, “Soso”) in Fukushima Prefecture, one of the areas most heavily affected by the Fukushima Daiichi Nuclear Power Plant accident.　The questionnaire focused on (1) health and school life of students; and (2) current initiatives and issues faced by yogo teachers in supporting student health. Results: We received responses from 8 of the 15 high school yogo teachers surveyed (response rate: 53.3％).Six yogo teachers (75％) responded that the “students are calm.” However, 6 yogo teachers (75％) recognized a tendency among students towards weight gain and obesity, as well as reduced physical stamina and sporting ability, while 4 yogo teachers (50％) indicated that some students were anxious about their future and career path, and were receiving personal support from the school counselor.　The yogo teachers provided support to students while attempting to ascertain their mental and physical well-being through greater health monitoring and questionnaires, and while coordinating with the school physician and counselor. Conclusion: Five years after the earthquake, high school students in the Soso district are now leading a more relaxed school life, but still feel anxious about their future health and career path due to lingering concerns about radiation, highlighting the need for long-term support by yogo teachers

Entrusting the Future of Rural Society through Nurturing Civic Pride: Endeavors in Gojome Town, Akita Prefecture of Japan

This photo essay illustrates a study on endeavors in a rural Japanese town with a declining population and discusses the future of rural society from a perspective of civic pride as well as sustainability. The population of the town of Gojome, located in Akita Prefecture of northern Japan, has halved from 20,025 in 1960 to 9,481 in 2015. Depopulation is often perceived as a half-empty glass, but we approached our study with the view that it is half-full. We discuss the issue through appreciative approaches by adopting the concept of “civic pride” as an alternative lens based on our empirical survey. The methodology adopted for this field survey include individual interviews with 126 respondents (consisting of 79 residents of Gojome and 47 individuals who were visiting the town) across different generations, 15 key informant interviews, drawings of their pride about the town by 34 sixth-graders of Gojome Elementary School, and observations. It was found that various generations of proud Gojome locals and non-locals have started to proactively participate in the process of bettering the town through various social, cultural, economic, and environmental activities. Based on our learning in Gojome town we conclude that, in the wake of rural depopulation, nurturing “civic pride” could potentially contribute to rural sustainability through entrusting the future of rural society to next generations

Curdione Plays an Important Role in the Inhibitory Effect of Curcuma aromatica on CYP3A4 in Caco-2 Cells

Curcuma aromatica is a plant belonging to genus Curcuma of family Zingiberaceae and is widely used as supplements in Japan. Rhizomes of C. aromatica have curcumin as a major yellow pigment and curdione as a main ingredient of essential oils. In this study, we investigated the affect of C. aromatica on CYP3A4 using 1α,25-(OH)2-D3-treated Caco-2 clone cells. Caco-2 cells were treated with methanol extract (0.1 mg ml−1), its hexane soluble fraction (0.1 mg ml−1), curcumin (4 μM) and curdione (20 μM) for 72 hours. Nifedipine was used as a substrate of CYP3A4. Methanol extract, hexane fraction and curdione inhibited the formation of oxidized nifedipine by 50–70%, and curcumin showed no effect. The IC50s of methanol extract, hexane fraction and curdione to oxidized nifedipine formation were 21, 14 and 3.9 μg ml−1 (16.9 μM), respectively. The content of curdione in methanol extract was 11.4%. Moreover, all of methanol extract, hexane fraction and curdione decreased CYP3A4 protein expression but had no affect on CYP3A4 mRNA expression. Our results showed that these drugs further decreased the CYP3A4 protein expression level after the protein synthesis was inhibited by cychroheximide. These findings suggest that curdione plays an important role in the CYP3A4 inhibitory activity of C. aromatica and curdione might inhibit the activity by accelerating the degradation of CYP3A4

Cloning and Characterization of a Streptomyces Single Module Type Non-ribosomal Peptide Synthetase Catalyzing a Blue Pigment Synthesis

In the present study, we cloned a gene, designated bpsA, which encodes a single module type non-ribosomal peptide synthetase (NRPS) from a d-cycloserine (DCS)-producing Streptomyces lavendulae ATCC11924. A putative oxidation domain is significantly integrated into the adenylation domain of the NRPS, and the condensation domain is absent from the module. When S. lividans was transformed with a plasmid carrying bpsA, the transformed cells produced a blue pigment, suggesting that bpsA is responsible for the blue pigment synthesis. However, to produce the blue pigment in Escherichia coli, the existence of the 4′-phosphopantetheinyl transferase (PPTase) gene from Streptomyces was necessary, in addition to bpsA. The chemical structure of the pigment was determined as 5,5′-diamino-4,4′-dihydroxy-3,3′-diazadiphenoquinone-(2,2′), called indigoidine. The bpsA gene product, designated BPSA, was overproduced in an E. coli host-vector system and purified to homogeneity, demonstrating that the recombinant enzyme prefers l-Gln as a substrate. The in vitro experiment using l-Gln also showed that the blue pigment was formed by the purified BPSA only when the enzyme was phosphopantetheinylated by adding a Streptomyces PPTase purified from E. coli cells. Each site-directed mutagenesis experiment of Lys598, Tyr601, Ser603, and Tyr608, which are seen in the oxidation domain of BPSA, suggests that these residues are essential for the binding of FMN to the protein and the synthesis of the blue pigment

Quality and safety issues related to traditional animal medicine: role of taurine

<p>Abstract</p> <p>Background</p> <p><it>Calculus Bovis</it> (:<it>C.Bovis</it>) is one of the most precious and commonly-used medicinal materials in Japan and China. As the natural occurrence is very rare, a source of supply for <it>C. Bovis</it> is far behind the actual need and great efforts have been taken for some substitutes of natural <it>C. Bovis</it>. Unfortunately, very little information is available on the quality and/or clinical efficacy of medication based on <it>C. Bovis</it>. To ensure sustainable use of traditional therapeutic agents derived from <it>C. Bovis</it>, we felt that several issues needed to be addressed: 1) the source of the <it>C. Bovis</it> materials and quality control; 2) the role of taurine in the efficacy of <it>C. Bovis</it>.</p> <p>Methods</p> <p>Nine samples of natural <it>C. Bovis</it> and its substitutes were collected. ICP-MS was used for elemental analysis and the characterization was performed by principal component analysis (PCA) and soft independent modeling of class analogy (SIMCA) as multivariate approaches. The efficacy of <it>C. Bovis</it> was evaluated for morphology, viability and beating pattern on cultured cardiac myocytes and/or fibroblasts.</p> <p>Results</p> <p>PCA and multi-elemental focus was effective in discriminating <it>C. Bovis</it> samples derived from different habitats. A satisfactory classification using SIMCA was obtained among Australia <it>C. Bovis</it>, other habitats and the substitutes. Australian samples had better batch uniformity than other habitats and were composed of fewer elements. We have used Australian<it> C. Bovis</it> for assessment on its bioactive compounds. Rat cardiac cells incubated with <it>C. Bovis</it> extract (0.01-0.1mg/ml) maintained normal morphology, viability and beating pattern. Cardiac myocytes and fibroblasts treated for 48 h with CA (0.5mM) or DCA (0.1mM) caused cell injury, as reflected by changes in appearance and a reduction of viability detected by the MTS assay. In cardiomyocytes, 0.5 h exposure of CA (0.5mM) markedly decreased the velocity ratio of beating, whereas the simultaneous addition of 1 mM taurine largely prevented the decrease.</p> <p>Conclusions</p> <p>The multi-elemental focus provided some references for the quality control and the efficacy of <it>C. Bovis</it>. Taurine partly attenuated the harmful actions of bile acids. It is plausible that the relationship between taurine and the bile acids contributes to therapeutic effect of <it>C. Bovis</it>.</p

Identifying Context-Specific Categories for Visualizing Livability of Cities—a Case Study of Malmö

Livability is a concept being applied to cities, even though it is vague. Worldwide, there are several livable city ranking schemes in use, which compare the livability of cities by making use of standardized indicator sets. The research presented here recognizes, as a point of departure, that each city is unique, implying that comparisons of cities by standardized categories only does not adequately reflect the reality of each city. A qualitative approach to identify context-specific categories of livability is proposed and employed to the case of Malmo ̈ in Sweden. Through interviews, nine context-specific categories were identified and visualized. The findings of the study demonstrate that a qualitative approach enables a more in-depth description of livability categories because it can capture and illustrate relationships among the categories. An explicit awareness of such relationships may provide a more holistic perspective to city officials and planners as they aim to improve the livability of their cities. The study concludes that a qualitative approach in identifying context-specific categories can complement existing assessment schemes and allow a better grasp of livability challenges to cities