A rhoptry antigen of Plasmodium falciparum is protective in Saimiri monkeys

A non-polymorphic antigen associated with the rhoptry organelles of Plasmodium falciparum has been purified by immuno-affinity chromatography. The antigen, RAP-1 (rhoptry associated protein-1). which is defined by monoclonal antibodies which inhibit parasite growth in vitro, is a multi-component antigen consisting of four major proteins of 80, 65, 42 and 40 kDa and two minor proteins of 77 and 70 kDa. These proteins were electro-eluted from preparative sodium dodecyl sulphate polyacrylamide gels and protected Saimiri sciureus monkeys from a lethal blood-stage infection of P. falciparum malaria. Sera from the protected animals recognized only proteins of the RAP-1 antigen when used to probe a Western blot of total parasite protein extract, confirming that RAP-1 is responsible for eliciting the protective immune respons

Magneto-radiotherapy: making the electrons conform

Magneto-radiotherapy is the application of magnetic fields during radiotherapy procedures. It aims to improve the quality of cancer treatment by using magnetic fields to alter the dose-deposition of secondary electrons in tissue. This work compares the performance of PENELOPE and EGS4 MC codes for magnetic fields applied to conventional photon beams. It also investigates the effect of a magnetic field on the electron spectrum and explores the novel idea of applying magnetic fields to MRT (Microbeam Radiation Therapy) for the treatment infantile brain tumours

Towards Precision LSST Weak-Lensing Measurement - I: Impacts of Atmospheric Turbulence and Optical Aberration

The weak-lensing science of the LSST project drives the need to carefully model and separate the instrumental artifacts from the intrinsic lensing signal. The dominant source of the systematics for all ground based telescopes is the spatial correlation of the PSF modulated by both atmospheric turbulence and optical aberrations. In this paper, we present a full FOV simulation of the LSST images by modeling both the atmosphere and the telescope optics with the most current data for the telescope specifications and the environment. To simulate the effects of atmospheric turbulence, we generated six-layer phase screens with the parameters estimated from the on-site measurements. For the optics, we combined the ray-tracing tool ZEMAX and our simulated focal plane data to introduce realistic aberrations and focal plane height fluctuations. Although this expected flatness deviation for LSST is small compared with that of other existing cameras, the fast f-ratio of the LSST optics makes this focal plane flatness variation and the resulting PSF discontinuities across the CCD boundaries significant challenges in our removal of the systematics. We resolve this complication by performing PCA CCD-by-CCD, and interpolating the basis functions using conventional polynomials. We demonstrate that this PSF correction scheme reduces the residual PSF ellipticity correlation below 10^-7 over the cosmologically interesting scale. From a null test using HST/UDF galaxy images without input shear, we verify that the amplitude of the galaxy ellipticity correlation function, after the PSF correction, is consistent with the shot noise set by the finite number of objects. Therefore, we conclude that the current optical design and specification for the accuracy in the focal plane assembly are sufficient to enable the control of the PSF systematics required for weak-lensing science with the LSST.Comment: Accepted to PASP. High-resolution version is available at http://dls.physics.ucdavis.edu/~mkjee/LSST_weak_lensing_simulation.pd

Generalized sine-Gordon/massive Thirring models and soliton/particle correspondences

We consider a real Lagrangian off-critical submodel describing the soliton sector of the so-called conformal affine $sl(3)^{(1)}$ Toda model coupled to matter fields (CATM). The theory is treated as a constrained system in the context of Faddeev-Jackiw and the symplectic schemes. We exhibit the parent Lagrangian nature of the model from which generalizations of the sine-Gordon (GSG) or the massive Thirring (GMT) models are derivable. The dual description of the model is further emphasized by providing the relationships between bilinears of GMT spinors and relevant expressions of the GSG fields. In this way we exhibit the strong/weak coupling phases and the (generalized) soliton/particle correspondences of the model. The $sl(n)^{(1)}$ case is also outlined.Comment: 22 pages, LaTex, some comments and references added, conclusions unchanged, to appear in J. Math. Phy

Generation and characterization of radiation in biomedical applications

This Creative Inquiry, Generation and Characterization of Radiation in Biomedical Applications, fuses two scientific disciplines, physics and bioengineering, seeking a common goal. Students under Dr. Takacs and Dr. Dean, including a doctoral candidate, are designing experiments to irradiate various biomaterials, including proteins and cancer cells, with monochromatic x-rays between 1000 eV to 15000 eV, and then study the results of those interactions. This specific creative inquiry\u27s (PHYS 2990-005 and BIOE 4510-025) goal for this semester is to further understand x-ray interactions with matter, specifically biomaterials. The bioengineering students are devising specific ways to cultivate certain proteins and cell cultures, and the physicists are designing parameters for the experiments, including the production and spectroscopy of x-rays. Several of the experiments will also be utilizing Clemson\u27s EBIT (electron beam ion trap, one of two in the country) as one of the sources for such radiation. With so little data collected using instrumentation of this precision, we feel that even our short-term goals will have far reaching implications

Single detector-dual scintillator anti-comptom probes

Anti¬-Compton spectrometers have many applications in the fields of safeguards, medicine and security. One of the most important applications is in the location of low energy gamma sources in the presence of high-¬energy gamma background or the location of high-¬energy gamma radiation sources hidden within the same spread of radiation background. In most situations space constraints limit the application of large size detectors or classical anti¬-Compton spectrometers. We have designed a compact anti-¬Compton spectrometer based on a single chip, dual silicon photodetector optically coupled to isolated, annular scintillators. Preliminary room temperature testing with Csl(TI) and LYSO scintillators demon¬strate the readout capabilities of the spectrometer concept. We have measured an outstanding energy resolution of 12 % and 8 % for the 511 keV line from a 22Na source used to excite a LYSO and Csl(TI) respectively. The other variants of Si-Csl(TI) probes is also discussed

Non-Equilibrium Statistical Physics of Currents in Queuing Networks

We consider a stable open queuing network as a steady non-equilibrium system of interacting particles. The network is completely specified by its underlying graphical structure, type of interaction at each node, and the Markovian transition rates between nodes. For such systems, we ask the question ``What is the most likely way for large currents to accumulate over time in a network ?'', where time is large compared to the system correlation time scale. We identify two interesting regimes. In the first regime, in which the accumulation of currents over time exceeds the expected value by a small to moderate amount (moderate large deviation), we find that the large-deviation distribution of currents is universal (independent of the interaction details), and there is no long-time and averaged over time accumulation of particles (condensation) at any nodes. In the second regime, in which the accumulation of currents over time exceeds the expected value by a large amount (severe large deviation), we find that the large-deviation current distribution is sensitive to interaction details, and there is a long-time accumulation of particles (condensation) at some nodes. The transition between the two regimes can be described as a dynamical second order phase transition. We illustrate these ideas using the simple, yet non-trivial, example of a single node with feedback.Comment: 26 pages, 5 figure

Beyond Zero-Sum Environmentalism

Environmental law and environmental protection are often portrayed as requiring trade offs: “jobs versus environment,” “markets versus regulation,” “enforcement versus incentives .” In the summer of 2016, members of the Environmental Law Collaborative gathered to consider how environmentalism and environmental regulation can advance beyond this framing to include new constituents and offer new pathways to tackle the many significant challenges ahead . Months later, the initial activities of the Trump Administration highlighted the use of zero-sum rhetoric, with the appointment of government officials and the issuance of executive orders that indeed seem to view environmental issues as in a zero-sum relationship with jobs or economic progress . In the essays below, the authors explore the meaning and the role of zero-sum environmentalism as a first step in moving beyond it