Pointed Hopf superalgebras of dimension up to 10

By utilizing the technique introduced in our previous work to construct Hopf superalgebras by an inverse procedure of the Radford-Majid bosonization, we classify non-semisimple pointed Hopf superalgebras of dimension up to 10 over an algebraically closed field of characteristic zero.Comment: 26 page

Five-Year Technological Changes of Distant Medical Education in Asia

All physicians would benefit from more comprehensive distance learning. However, the technology is often difficult to use because technological infrastructure is limited in many hospitals in Asia. Since 2003, we have worked to advance international distant medical education implemented through the Internet in Asia. This paper presents an analysis of our activities over the past five years to evaluate the technical transition and its effects on modes of distant medical education. Methods: We analysed distant medical education programmes that we conducted from 2011 to 2015. We used a Digital Video Transport System (DVTS), H.323 and Vidyo, along with commercial and research and education networks (REN) installed in the subject hospitals. Questionnaires were randomly distributed to the audience to evaluate image resolution, image movement, sound quality, and programme content. Results: The number of programmes increased to over 90 per year in 2014–2015. The main system gradually changed from DVTS (58%, 30/52 in 2011) to Vidyo (64%, 67/104 in 2015). The number of new institutions increased to 149 in 2014–2015. Over 92% of the ratings for image resolution and movement were positive. Sound quality was somewhat lower at 83%. Ultimately, 98% of respondents rated the programmes “very good” or “good.” Conclusions: Continuous technical development was observed with increasing numbers of sites for each programme. This resulted in expansion of activity involving non-university hospitals. Practical distant medical education, satisfies physicians’ need for quality and inclusiveness could be expanded to normal hospitals in Asia and beyond

How to Prevent Technical Issues in Large Multiparty Medical Videoconferencing

Introduction: Videoconferencing (VC) is useful for physicians who need to learn about many cases without moving from one institution to another. However, this advantage can be hampered by technical issues. This study aims to analyse the factors relating technical support that cause technical issues in regular multiparty medical VC to provide high-quality VC to meet participants’ demands. Methods: The study includes large multiparty VC between the Kyushu University Hospital Department of Paediatric Surgery and different institutions within Japan that were held from September 2014 to January 2017. Technical tests, a “previous-week test” and a “last-hour test,” were conducted for checking conditions prior to the VC. The chi-square test was used for factors: participation for previous-week and last-hour test, and attendance by an engineer VCs in each participating institution. A questionnaire survey was distributed among the participants to collect feedback on the quality of VC, ease of preparation and necessity of previous-week testing. Results: Participation in the last-hour test (P=0.002) and the presence of an engineer (P=0.049) significantly decreased overall technical issues. The last-hour tests significantly decreased disconnection (P=0.015) and audio (P=0.019) issues. The engineer’s attendance decreased content-sharing issues (P=0.027). Participants reporting “very good” and “good” audio and visual quality were 92% (109/118) and 96% (105/110). Eighty-three percent of participants (82/99) found the preparation “very easy” or “easy”; while 61% (63/103) found the previous-week test, “unnecessary.” Conclusions: Based on our study, “engineers’ attendance” and “last-hour” technical testing significantly reduced technical problems; these factors help provide high-quality output VC and meet the needs of the participants

Potential demand for eco-museum excursions in Higashihiroshima City

エコミュージアムにおいて，地域に散在する遺産をどのように結びつけるかは1つの課題である。1つの解決策として，域内をめぐる見学ツアーを提供することが考えられる。本稿の目的は，東広島市で想定できるエコミュージアム・ツアーにどの程度の需要が見込めるのかを示すことである。そのために，広島県民へのウェブアンケート調査と，広島大学学生の意見調査を行った。ウェブアンケートからは，エコミュージアムに関心をもつ層が3分の1おり，ツアーへの参加希望は，「水と酒」をテーマとするものが56.0％，「生物と農村生活」で44.9％，「バイオマス関連」で40.3％，「伝説と歴史」で30.3％であることが示された。また，学生の意見としては，大学のある地域について知る機会を大事にしたい，日常的に自然に接する機会が少ないので提示された機会は貴重だと考える者がいる一方，参加費用面でそもそも無理だと判断する者がおり，両者はほぼ半々となった。見学ツアーに対して，広島大学総合博物館単独での実施能力を大きく上回る潜在的な需要があることが確認できた。Finding ways to connect scattered heritages in an eco-museum constitutes an issue. Solutions include providing excursions around the region. This article aims to demonstrate how much demand can be expected for the excursions of an eco-museum in Higashihiroshima City. To this end, an online questionnaire survey was administered to citizens of Hiroshima Prefecture, and an opinion survey of Hiroshima University students was conducted. According to the online survey, 56.0% of respondents were interested in participating in the excursion on the theme of “water and liquor”, and 44.9% were interested in the excursion regarding “wild living and rural life”. Further, 40.3% were interested in the “biomass-related” excursion and 30.3% were interested in the excursion on “local history and legends”. The opinions of university students were as follows. Almost half the students stated that the presented opportunities are valuable as they want to learn about the area surrounding the university and there are few opportunities to interact with nature in everyday life. Conversely, the other half of participants deemed the participation fee excessively high. The results confirmed that there is a potential demand for excursions, and that it exceeds the capacity that the museum can manage.ウェブアンケート調査について科学研究費（基盤研究（C），19K01186，代表：淺野敏久）を使用した

Prolyl Isomerase Pin1 Directly Regulates Calcium/Calmodulin-Dependent Protein Kinase II Activity in Mouse Brains

Calcium/calmodulin-dependent protein kinase II (CaMKII) is abundant in the brain and functions as a mediator of calcium signaling. We found that the relative activity of CaMKII was significantly lower in the WT mouse brains than in the Pin1-/- mouse brains. Pin1 binds to phosphorylated CaMKII and weakens its activity. For this reason, the phosphorylation level of tau in the presence of Pin1 is lower than that in the absence of Pin1, and microtubule polymerization is not downregulated by CaMKII when Pin1 is present. These results suggest a novel mechanism of action of Pin1 to prevent neurodegeneration

Evolutional transition of HBV genome during the persistent infection determined by single-molecule real-time sequencing

BACKGROUND: Although HBV infection is a serious health issue worldwide, the landscape of HBV genome dynamics in the host has not yet been clarified. This study aimed to determine the continuous genome sequence of each HBV clone using a single-molecule real-time sequencing platform, and clarify the dynamics of structural abnormalities during persistent HBV infection without antiviral therapy. PATIENTS AND METHODS: Twenty-five serum specimens were collected from 10 untreated HBV-infected patients. Continuous whole-genome sequencing of each clone was performed using a PacBio Sequel sequencer; the relationship between genomic variations and clinical information was analyzed. The diversity and phylogeny of the viral clones with structural variations were also analyzed. RESULTS: The whole-genome sequences of 797, 352 HBV clones were determined. The deletion was the most common structural abnormality and concentrated in the preS/S and C regions. Hepatitis B e antibody (anti-HBe)-negative samples or samples with high alanine aminotransferase levels have significantly diverse deletions than anti-HBe-positive samples or samples with low alanine aminotransferase levels. Phylogenetic analysis demonstrated that various defective and full-length clones evolve independently and form diverse viral populations. CONCLUSIONS: Single-molecule real-time long-read sequencing revealed the dynamics of genomic quasispecies during the natural course of chronic HBV infections. Defective viral clones are prone to emerge under the condition of active hepatitis, and several types of defective variants can evolve independently of the viral clones with the full-length genome

Application of the symbolic regression program AI-Feynman to psychology

The discovery of hidden laws in data is the core challenge in many fields, from the natural sciences to the social sciences. However, this task has historically relied on human intuition and experience in many areas, including psychology. Therefore, discovering laws using artificial intelligence (AI) has two significant advantages. First, it makes it possible to detect laws that humans cannot discover. Second, it will help construct more accurate theories. An AI called AI-Feynman was released in a very different field, and it performed impressively. Although AI-Feynman was initially designed to discover laws in physics, it can also work well in psychology. This research aims to examine whether AI-Feynman can be a new data analysis method for inter-temporal choice experiments by testing whether it can discover the hyperbolic discount model as a discount function. An inter-temporal choice experiment was conducted to accomplish these objectives, and the data were input into AI-Feynman. As a result, seven discount function candidates were proposed by AI-Feynman. One candidate was the hyperbolic discount model, which is currently considered the most accurate. The three functions of the root-mean-squared errors were superior to the hyperbolic discount model. Moreover, one of the three candidates was more “hyperbolic” than the standard hyperbolic discount function. These results indicate two things. One is that AI-Feynman can be a new data analysis method for inter-temporal choice experiments. The other is that AI-Feynman can discover discount functions that humans cannot find

Dynamics of proteins with different molecular structures under solution condition

Incoherent quasielastic neutron scattering (iQENS) is a fascinating technique for investigating the internal dynamics of protein. However, low flux of neutron beam, low signal to noise ratio of QENS spectrometers and unavailability of well-established analyzing method have been obstacles for studying internal dynamics under physiological condition (in solution). The recent progress of neutron source and spectrometer provide the fine iQENS profile with high statistics and as well the progress of computational technique enable us to quantitatively reveal the internal dynamic from the obtained iQENS profile. The internal dynamics of two proteins, globular domain protein (GDP) and intrinsically disordered protein (IDP) in solution, were measured with the state-of-the art QENS spectrometer and then revealed with the newly developed analyzing method. It was clarified that the average relaxation rate of IDP was larger than that of GDP and the fraction of mobile H atoms of IDP was also much higher than that of GDP. Combined with the structural analysis and the calculation of solvent accessible surface area of amino acid residue, it was concluded that the internal dynamics were related to the highly solvent exposed amino acid residues depending upon protein’s structure