Multiplexed Illumination for Classifying Visually Similar Objects

Distinguishing visually similar objects like forged/authentic bills and healthy/unhealthy plants is beyond the capabilities of even the most sophisticated classifiers. We propose the use of multiplexed illumination to extend the range of objects that can be successfully classified. We construct a compact RGB-IR light stage that images samples under different combinations of illuminant position and colour. We then develop a methodology for selecting illumination patterns and training a classifier using the resulting imagery. We use the light stage to model and synthetically relight training samples, and propose a greedy pattern selection scheme that exploits this ability to train in simulation. We then apply the trained patterns to carry out fast classification of new objects. We demonstrate the approach on visually similar artificial and real fruit samples, showing a marked improvement compared with fixed-illuminant approaches as well as a more conventional code selection scheme. This work allows fast classification of previously indistinguishable objects, with potential applications in forgery detection, quality control in agriculture and manufacturing, and skin lesion classification.Comment: Submitted to Computer Vision and Image Understanding (CVIU

BPTF promotes tumor growth and predicts poor prognosis in lung adenocarcinomas.

BPTF, a subunit of NURF, is well known to be involved in the development of eukaryotic cell, but little is known about its roles in cancers, especially in non-small-cell lung cancer (NSCLC). Here we showed that BPTF was specifically overexpressed in NSCLC cell lines and lung adenocarcinoma tissues. Knockdown of BPTF by siRNA significantly inhibited cell proliferation, induced cell apoptosis and arrested cell cycle progress from G1 to S phase. We also found that BPTF knockdown downregulated the expression of the phosphorylated Erk1/2, PI3K and Akt proteins and induced the cleavage of caspase-8, caspase-7 and PARP proteins, thereby inhibiting the MAPK and PI3K/AKT signaling and activating apoptotic pathway. BPTF knockdown by siRNA also upregulated the cell cycle inhibitors such as p21 and p18 but inhibited the expression of cyclin D, phospho-Rb and phospho-cdc2 in lung cancer cells. Moreover, BPTF knockdown by its specific shRNA inhibited lung cancer growth in vivo in the xenografts of A549 cells accompanied by the suppression of VEGF, p-Erk and p-Akt expression. Immunohistochemical assay for tumor tissue microarrays of lung tumor tissues showed that BPTF overexpression predicted a poor prognosis in the patients with lung adenocarcinomas. Therefore, our data indicate that BPTF plays an essential role in cell growth and survival by targeting multiply signaling pathways in human lung cancers

Ku80 cooperates with CBP to promote COX-2 expression and tumor growth.

Cyclooxygenase-2 (COX-2) plays an important role in lung cancer development and progression. Using streptavidin-agarose pulldown and proteomics assay, we identified and validated Ku80, a dimer of Ku participating in the repair of broken DNA double strands, as a new binding protein of the COX-2 gene promoter. Overexpression of Ku80 up-regulated COX-2 promoter activation and COX-2 expression in lung cancer cells. Silencing of Ku80 by siRNA down-regulated COX-2 expression and inhibited tumor cell growth in vitro and in a xenograft mouse model. Ku80 knockdown suppressed phosphorylation of ERK, resulting in an inactivation of the MAPK pathway. Moreover, CBP, a transcription co-activator, interacted with and acetylated Ku80 to co-regulate the activation of COX-2 promoter. Overexpression of CBP increased Ku80 acetylation, thereby promoting COX-2 expression and cell growth. Suppression of CBP by a CBP-specific inhibitor or siRNA inhibited COX-2 expression as well as tumor cell growth. Tissue microarray immunohistochemical analysis of lung adenocarcinomas revealed a strong positive correlation between levels of Ku80 and COX-2 and clinicopathologic variables. Overexpression of Ku80 was associated with poor prognosis in patients with lung cancers. We conclude that Ku80 promotes COX-2 expression and tumor growth and is a potential therapeutic target in lung cancer

Dataset: Multiplexed Illumination for Classifying Visually Similar Objects

This dataset accompanies the paper Multiplexed Illumination for Classifying Visually Similar Objects. Project details are here: https://roboticimaging.org/Projects/LSClassifier/ The dataset contains 16000 10-bit images of five types of real and synthetic fruit. It is split across three categories: Relightable models: high-quality single-illuminant images. These drive the pattern selection and classifier training, and can be used to devise and evaluate new multiplexing schemes. SNR-Optimal: Captured with inference-time conditions, with more evident noise, and with illumination patterns selected to be optimal in terms of signal-to-noise (SNR) ratio. Greedy: Also captured with inference-time conditions, these patterns were jointly trained along with the classifier using our proposed greedy pattern selection scheme. Preprint of paper available at: https://arxiv.org/abs/2009.1108

Overestimated global dryland expansion with substantial increases in vegetation productivity under climate warming

Drylands are serviced as an essential component of the earth’s ecosystem. The potential changes in dryland areas are of great importance to the environment, but various debates remain as to whether and to what extent drylands are expected to expand. Here we employ a physically-based potential evapotranspiration ( E _P ) model accounting for vegetation response to climate change to quantify potential changes in dryland areas, on the basis of a commonly used indicator, aridity index (multiyear mean E _P over precipitation). Results show that by the end of this century, drylands will expand slightly by ∼5%, while vegetation productivity will increase by ∼50%. Elevated CO _2 slows down the increase rate of E _P that impedes the expansion of drylands, but greatly promotes vegetation growth with increases in both leaf assimilation and canopy foliage. These findings improve our understanding of the potential changes in dryland and their ecological impacts in a warmer climate

Divergent responses of permafrost degradation to precipitation increases at different seasons on the eastern Qinghai–Tibet Plateau based on modeling approach

The Qinghai–Tibet Plateau (QTP) has responded to remarkable climate warming with dramatic permafrost degradation over the past few decades. Previous studies have mostly focused on permafrost responses to rising air temperature, while the effects of accompanying increases in precipitation remain contentious and largely unknown. In this study, a distributed process-based model was applied to quantify the impacts of increased precipitation on permafrost thermal regimes in a warming climate by employing model experiments in the source region of Yellow River (SRYR) on the eastern QTP. The results showed that the active layer thickness (ALT) of permafrost increased by 0.25 m during 2010–2019 compared to 2000 across the SRYR, which was primarily driven by climate warming. In contrast, the increased annual precipitation played a relatively limited role and just slightly mitigated active layer thickening by 0.03 m. Intriguingly, increased precipitation in the cold and warm seasons exerted opposite effects on permafrost across the SRYR. The increased precipitation in the cold season mainly promoted ALT increases, while the increased precipitation in the warm season mitigated ALT increases. In ∼81.0% of the permafrost across the SRYR, the cooling effects of warm season wetting outweighed the warming effects of cold season wetting; while at the transition zone where permafrost was unstable and degrading to seasonally frozen ground, the warming effects of cold season wetting played a relatively larger role which contributed to permafrost degradation. This study explored the physical mechanisms of permafrost thermal responses to climate wetting, thus providing a better understanding of permafrost change in a warmer and wetter climate on the QTP

Quantifying the impact of the Three Gorges Reservoir on historical and future extreme hydrological events

This data archive includes a coupled network model simulating TGR operation, as well as two sample programs that can be used in MATLAB. And the historical inflow and future inflow of different socio-economic paths used for model input in the study

hardnessmeasurementandevaluationofthinfilmonmaterialsurface

给出了基于纳米硬度试验的表层薄膜的硬度测算方法。首先研究如何利用有限元计算弥补纳米硬度测量在压痕深度小于百纳米时的精度缺陷，进而探讨薄膜一基体材料系统的硬度随压痕深度变化的规律，最后导出了根据实验曲线预测表层薄膜材料的硬度的公式，并进行了实验验证