1,801 research outputs found
Examining summer laboratory research apprenticeships for high school students as a factor in entry to MD/PhD programs at matriculation
Understanding and supporting Attention Deficit Hyperactivity Disorder (ADHD) in the primary school classroom:Perspectives of children with ADHD and their teachers
Molecular Electrochemical Catalysis of the CO 2 -to-CO Conversion with a Co Complex: A Cyclic Voltammetry Mechanistic Investigation
International audienceThe electrochemical catalytic reduction of CO2 into CO could be achieved with excellent selectivity and rate in acetonitrile in the presence of phenol with cobalt 2,2′:6′,2″:6″,2‴-quaterpyridine complex [CoII(qpy)(H2O)2]2+ (Co) acting as a molecular catalyst. Upon using cyclic voltammetry at low and high scan rate (up to 500 V/s) two catalytic pathways have been identified. At a low concentration of phenol (<1 M), catalysis mainly occurs after the reduction of Co with three electrons. In that case, the selectivity for CO production is ca. 80% with 20% of H2 as by product, along with a turnover frequency of 1.2 × 104 s−1 for COproduction at an overpotential η of ca. 0.6 V. The triply reduced active species binds to CO2 and the C−O bond is cleaved thanks to the acid. At very large concentration of phenol (3 M), another pathway becomes predominant: the doubly reduced species binds to CO2, while its reductive protonation leads to CO formation. As already shown, this later process is endowed with fast rate at low overpotential (turnover frequency of 3 × 104 s−1 at η = 0.3 V) and 95% selectivity for CO production. By varying the phenol concentration and the scan rate in voltammetry experiments, it was thus possible to identify, activate, and characterize several pathways for the CO2-to-CO conversion and to decipher Co electrochemical reactivity toward CO2
Evidence of Self-Directed Learning on a High School Robotics Team
Self-directed learning is described as an individual taking the initiative to engage in a learning experience while assuming responsibility to follow through to its conclusion. Robotics competitions are examples of informal environments that can facilitate self-directed learning. This study examined how mentor involvement, student behavior, and physical workspace contributed to self-directed learning on one robotics competition team. How did mentors transfer responsibility to students? How did students respond to managing a team? Are the physical attributes of a workspace important? The mentor, student, and workplace factors captured in the research showed mentors wanting students to do the work, students assuming leadership roles, and the limited workspace having a positive effect on student productivity
RESPONSE: Re: Breast-Conserving Surgery With or Without Radiotherapy: Pooled-Analysis for Risks of Ipsilateral Breast Tumor Recurrence and Mortality
Diffusing an Innovation: Clinician Perceptions of Continuous Predictive Analytics Monitoring in Intensive Care
Background The purpose of this article is to describe neonatal intensive care unit
clinician perceptions of a continuous predictive analytics technology and how those
perceptions influenced clinician adoption. Adopting and integrating new technology
into care is notoriously slow and difficult; realizing expected gains remain a challenge.
Methods Semistructured interviews from a cross-section of neonatal physicians
(n ¼ 14) and nurses (n ¼ 8) from a single U.S. medical center were collected 18 months
following the conclusion of the predictive monitoring technology randomized control
trial. Following qualitative descriptive analysis, innovation attributes from Diffusion of
Innovation Theory-guided thematic development.
Results Results suggest that the combination of physical location as well as lack of
integration into work flow or methods of using data in care decisionmaking may have
delayed clinicians from routinely paying attention to the data. Once data were routinely
collected, documented, and reported during patient rounds and patient handoffs,
clinicians came to view data as another vital sign. Through clinicians’ observation of
senior physicians and nurses, and ongoing dialogue about data trends and patient
status, clinicians learned how to integrate these data in care decision making (e.g.,
differential diagnosis) and came to value the technology as beneficial to care delivery.
Discussion The use of newly created predictive technologies that provide early warning of
illness may require implementation strategies that acknowledge the risk–benefit of
treatment cliniciansmust balance and take advantage of existing clinician trainingmethods
The clinically led worforcE and activity redesign (CLEAR) programme: a novel data-driven healthcare improvement methodology
Background: The NHS is facing substantial pressures to recover from the COVID-19 pandemic. Optimising workforce modelling is a fundamental component of the recovery plan. The Clinically Lead workforcE and Activity Redesign (CLEAR) programme is a unique methodology that trains clinicians to redesign services, building intrinsic capacity and capability, optimising patient care and minimising the need for costly external consultancy. This paper describes the CLEAR methodology and the evaluation of previous CLEAR projects, including the return on investment. Methods: CLEAR is a work-based learning programme that combines qualitative techniques with data analytics to build innovations and new models of care. It has four unique stages: (1) Clinical engagement- used to gather rich insights from stakeholders and clinicians. (2) Data interrogation- utilising clinical and workforce data for cohort analysis. (3) Innovation- using structured innovation methods to develop new models of care. (4) Recommendations- report writing, impact assessment and presentation of key findings to executive boards. A mixed-methods formative evaluation was carried out on completed projects, which included semi-structured interviews and surveys with CLEAR associates and stakeholders, and a health economic logic model that was developed to link the inputs, processes, outputs and the outcome of CLEAR as well as the potential impacts of the changes identified from the projects. Results: CLEAR provides a more cost-effective delivery of complex change programmes than the alternatives – resulting in a cost saving of £1.90 for every £1 spent independent of implementation success. Results suggest that CLEAR recommendations are more likely to be implemented compared to other complex healthcare interventions because of the levels of clinical engagement and have a potential return on investment of up to £14 over 5 years for every £1 invested. CLEAR appears to have a positive impact on staff retention and wellbeing, the cost of a CLEAR project is covered if one medical consultant remains in post for a year. Conclusions: The unique CLEAR methodology is a clinically effective and cost-effective complex healthcare innovation that optimises workforce and activity design, as well as improving staff retention. Embedding CLEAR methodology in the NHS could have substantial impact on patient care, staff well-being and service provision
Regional differences in prostaglandin Eâ‚‚ metabolism in human colorectal cancer liver metastases
Background: Prostaglandin (PG) E₂ plays a critical role in colorectal cancer (CRC) progression, including epithelial-mesenchymal transition (EMT). Activity of the rate-limiting enzyme for PGE₂ catabolism (15-hydroxyprostaglandin dehydrogenase [15-PGDH]) is dependent on availability of NAD+. We tested the hypothesis that there is intra-tumoral variability in PGE₂ content, as well as in levels and activity of 15-PGDH, in human CRC liver metastases (CRCLM). To understand possible underlying mechanisms, we investigated the relationship between hypoxia, 15-PGDH and PGE₂ in human CRC cells in vitro. Methods: Tissue from the periphery and centre of 20 human CRCLM was analysed for PGE₂ levels, 15-PGDH and cyclooxygenase (COX)-2 expression, 15-PGDH activity, and NAD+/NADH levels. EMT of LIM1863 human CRC cells was induced by transforming growth factor (TGF) β. Results: PGE₂ levels were significantly higher in the centre of CRCLM compared with peripheral tissue (P = 0.04). There were increased levels of 15-PGDH protein in the centre of CRCLM associated with reduced 15-PGDH activity and low NAD+/NADH levels. There was no significant heterogeneity in COX-2 protein expression. NAD+ availability controlled 15-PGDH activity in human CRC cells in vitro. Hypoxia induced 15-PGDH expression in human CRC cells and promoted EMT, in a similar manner to PGE₂. Combined 15-PGDH expression and loss of membranous E-cadherin (EMT biomarker) were present in the centre of human CRCLM in vivo.Conclusions: There is significant intra-tumoral heterogeneity in PGE₂ content, 15-PGDH activity and NAD+ availability in human CRCLM. Tumour micro-environment (including hypoxia)-driven differences in PGE₂ metabolism should be targeted for novel treatment of advanced CRC
Performance Measures Based on How Adults With Cancer Feel and Function: Stakeholder Recommendations and Feasibility Testing in Six Cancer Centers
PURPOSE Patient-reported outcome measures (PROMs) that assess how patients feel and function have potential for evaluating quality of care. Stakeholder recommendations for PRO-based performance measures (PMs) were elicited, and feasibility testing was conducted at six cancer centers. METHODS Interviews were conducted with 124 stakeholders to determine priority symptoms and risk adjustment variables for PRO-PMs and perceived acceptability. Stakeholders included patients and advocates, caregivers, clinicians, administrators, and thought leaders. Feasibility testing was conducted in six cancer centers. Patients completed PROMs at home 5-15 days into a chemotherapy cycle. Feasibility was operationalized as 75% patient acceptability. RESULTS Stakeholder priority PRO-PMs for systemic therapy were GI symptoms (diarrhea, constipation, nausea, vomiting), depression/anxiety, pain, insomnia, fatigue, dyspnea, physical function, and neuropathy. Recommended risk adjusters included demographics, insurance type, cancer type, comorbidities, emetic risk, and difficulty paying bills. In feasibility testing, 653 patients enrolled (approximately 110 per site), and 607 (93%) completed PROMs, which indicated high feasibility for home collection. The majority of patients (470 of 607; 77%) completed PROMs without a reminder call, and 137 (23%) of 607 completed them after a reminder call. Most patients (72%) completed PROMs through web, 17% paper, or 2% interactive voice response (automated call that verbally asked patient questions). For acceptability, . 95% of patients found PROM items to be easy to understand and complete. CONCLUSION Clinicians, patients, and other stakeholders agree that PMs that are based on how patients feel and function would be an important addition to quality measurement. This study also shows that PRO-PMs can be feasibly captured at home during systemic therapy and are acceptable to patients. PRO-PMs may add value to the portfolio of PMs as oncology transitions from fee-for-service payment models to performance-based care that emphasizes outcome measures
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