739 research outputs found
ANTI-VIRAL EFFECT OF HERBAL MEDICINE KOREAN TRADITIONAL CYNANCHUM PANICULATUM (BGE.) KITAG EXTRACTS
Background: Pestiviruses in general, and Bovine Viral Diarrhea (BVD) in particular, present several potential targets
for directed antiviral therapy.
Material and Methods: The antiviral effect of Cynanchum paniculatum (Bge.) Kitag (Dog strangling vine: DS)
extract on the bovine viral diarrhea (BVD) virus was tested. First, a cytotoxicity test in MDBK (Madin-Darby bovine
kidney) cells was done with all organic extract concentrations.
Results: The cytotoxic concentration CC50 for the ethyl acetate (EA) extracts was 18.2 ug/ml. In the tissue culture,
infectious dose (TCID50) assay, the BVD virus decreased when treated with 18.2 ug/ml of the ethyl acetate extracts.
Conclusion: Ethyl acetate extracts and fractions of the DS extract could be used as a potential antiviral for BVD
MPSR1 is a cytoplasmic PQC E3 ligase for eliminating emergent misfolded proteins in <i>Arabidopsis thaliana</i>
Traversable Wormholes Construction in 2+1 Dimensions
We study traversable Lorentzian wormholes in the three-dimensional low energy
string theory by adding some matter source involving a dilaton field. It will
be shown that there are two-different types of wormhole solutions such as BTZ
and black string wormholes depending on the dilaton backgrounds, respectively.
We finally obtain the desirable solutions which confine exotic matter near the
throat of wormhole by adjusting NS charge.Comment: 12 pages, 4 figures, JHEP style, one reference adde
Development of a robust pH-sensitive polyelectrolyte ionomer complex for anticancer nanocarriers
Realization of giant magnetoelectricity in helimagnets
We show that low field magnetoelectric (ME) properties of helimagnets
Ba0.5Sr1.5Zn2(Fe1-xAlx)12O22 can be efficiently tailored by Al-substitution
level. As x increases, the critical magnetic field for switching electric
polarization is systematically reduced from ~1 T down to ~1 mT, and the ME
susceptibility is greatly enhanced to reach a giant value of 2.0 x 10^4 ps/m at
an optimum x = 0.08. We find that control of nontrivial orbital moment in the
octahedral Fe sites through the Al-substitution is crucial for fine tuning of
magnetic anisotropy and obtaining the conspicuously improved ME
characteristics
Transcortical Alterations in Na+-K+ ATPase and Microtubule-Associated Proteins Immunoreactivity in the Rat Cortical Atrophy Model Induced by Hypoxic Ischemia
To identify the chronological transcortical
change in the contralateral hemisphere
following ischemic insults, we investigated the
changes in microtubule associated protein
(MAP) and Na+-K+ ATPase expressions in the
peri-infarct zone and contralateral hemisphere,
including the hippocampus. Two days after
hypoxic ischemia, Na+-K+ ATPase immunoreactivity
was significantly enhanced in the
contralateral cortex and was maintained up to 7
days after ischemia, whereas Na+-K+ ATPase immunoreactivity in the peri- and infarct zones
was unaffected by hypoxic ischemia. In contrast,
2 to 7 days after ischemia, MAP1A and MAP2
immunoreactivity in the ipsi- and contralateral
cortex significantly decreased, whereas in layer
V, MAP1 immunoreactivity obviously accumulated
in the neurons and their processes. In the
hippocampus, 2 days after insults both MAP1A
and MAP2 immunoreactivity was significantly
reduced within the ipsi- and contralateral
hippocampus. In the contralateral hippocampus,
however, the distribution of MAP2 immunoreactivity
recovered to the sham level 7 days
after ischemia, whereas MAP1A immunoreactive
axons remained 2 months after
ischemia. The results suggest that the unilateral
elevation of Na+-K+ ATPase immunoreactivity
reflects elevated neuronal activity. In addition,
this asymmetric hyperexcitability might play an
important role in the recovery or the
reorganization of the brain, accompanied by
transcortical changes in MAPs expression
THE EFFECT OF TAILORED ANTIPLATELET THERAPEUTIC STRATEGY DURING PERCUTANEOUS CORONARY INTERVENTION ON PERIPROCEDURAL MYONECROSIS IN DIABETIC PATIENTS: INSIGHTS FROM THE DM-VERIFYNOW STUDY
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