Failure of conductance quantization in two-dimensional topological insulators due to non-magnetic impurities

Despite topological protection and the absence of magnetic impurities, two-dimensional topological insulators display quantized conductance only in surprisingly short channels, which can be as short as 100 nm for atomically thin materials. We show that the combined action of short-range nonmagnetic impurities located near the edges and on site electron-electron interactions effectively creates noncollinear magnetic scatterers, and, hence, results in strong backscattering. The mechanism causes deviations from quantization even at zero temperature and for a modest strength of electron-electron interactions. Our theory provides a straightforward conceptual framework to explain experimental results, especially those in atomically thin crystals, plagued with short-range edge disorder.Comment: 8 pages, 9 figures, 5 appendice

Superconductors as ideal spin sources for spintronics

Spin-polarized transport is investigated in normal metal-superconductor (NS) junctions as a function of interface transmissivity as well as temperature when the density of states of a superconductor is Zeeman-split in response to an exchange field (h_exc). Similarly to the "absolute spin-valve effect" predicted by D. Huertas-Hernando et al. [Phys. Rev. Lett. 88, 047003 (2002)] in superconducting proximity structures, we show that NS junctions can be used to generate highly spin-polarized currents, in alternative to half-metallic ferromagnets. In particular, the spin-polarized current obtained is largely tunable in magnitude and sign by acting on bias voltage and h_exc. While for tunnel contacts the current polarization can be as high as 100%, for transparent junctions it is dominated by the minority spin species. The effect can be enhanced by electron "cooling" provided by the superconducting gap.Comment: 4 pages, 4 color figures, published versio

Electronic Hong-Ou-Mandel interferometer for multi-mode entanglement detection

We show that multi-mode entanglement of electrons in a mesoscopic conductor can be detected by a measurement of the zero-frequency current correlations in an electronic Hong-Ou-Mandel interferometer. By this mean, one can further establish a lower bound to the entanglement of formation of two-electron input states. Our results extend the work of Burkard and Loss [Phys. Rev. Lett. 91, 087903 (2003)] to many channels and provide a way to test the existence of entangled states involving both orbital and spin degrees of freedom.Comment: 6 pages. Revised version. Ref. adde

Manipulating nonequilibrium magnetism through superconductors

Electrostatic control of the magnetization of a normal mesoscopic conductor is analyzed in a hybrid superconductor-normal-superconductor system. This effect stems from the interplay between the non-equilibrium condition in the normal region and the Zeeman splitting of the quasiparticle density of states of the superconductor subjected to a static in-plane magnetic field. Unexpected spin-dependent effects such as magnetization suppression, diamagnetic-like response of the susceptibility as well as spin-polarized current generation are the most remarkable features presented. The impact of scattering events is evaluated and let us show that this effect is compatible with realistic material properties and fabrication techniques.Comment: 5 pages, 4 figure

Crowdsourcing malaria parasite quantification: an online game for analyzing images of infected thick blood smears

Background: There are 600,000 new malaria cases daily worldwide. The gold standard for estimating the parasite burden and the corresponding severity of the disease consists in manually counting the number of parasites in blood smears through a microscope, a process that can take more than 20 minutes of an expert microscopist’s time. Objective: This research tests the feasibility of a crowdsourced approach to malaria image analysis. In particular, we investigated whether anonymous volunteers with no prior experience would be able to count malaria parasites in digitized images of thick blood smears by playing a Web-based game. Methods: The experimental system consisted of a Web-based game where online volunteers were tasked with detecting parasites in digitized blood sample images coupled with a decision algorithm that combined the analyses from several players to produce an improved collective detection outcome. Data were collected through the MalariaSpot website. Random images of thick blood films containing Plasmodium falciparum at medium to low parasitemias, acquired by conventional optical microscopy, were presented to players. In the game, players had to find and tag as many parasites as possible in 1 minute. In the event that players found all the parasites present in the image, they were presented with a new image. In order to combine the choices of different players into a single crowd decision, we implemented an image processing pipeline and a quorum algorithm that judged a parasite tagged when a group of players agreed on its position. Results: Over 1 month, anonymous players from 95 countries played more than 12,000 games and generated a database of more than 270,000 clicks on the test images. Results revealed that combining 22 games from nonexpert players achieved a parasite counting accuracy higher than 99%. This performance could be obtained also by combining 13 games from players trained for 1 minute. Exhaustive computations measured the parasite counting accuracy for all players as a function of the number of games considered and the experience of the players. In addition, we propose a mathematical equation that accurately models the collective parasite counting performance. Conclusions: This research validates the online gaming approach for crowdsourced counting of malaria parasites in images of thick blood films. The findings support the conclusion that nonexperts are able to rapidly learn how to identify the typical features of malaria parasites in digitized thick blood samples and that combining the analyses of several users provides similar parasite counting accuracy rates as those of expert microscopists. This experiment illustrates the potential of the crowdsourced gaming approach for performing routine malaria parasite quantification, and more generally for solving biomedical image analysis problems, with future potential for telediagnosis related to global health challenges

Spin-dependent Transparency of Ferromagnet/Superconductor Interfaces

Because the physical interpretation of the spin-polarization of a ferromagnet determined by point-contact Andreev reflection (PCAR) is non-trivial, we have carried out parameter-free calculations of PCAR spectra based upon a scattering-theory formulation of Andreev reflection generalized to spin-polarized systems and a tight-binding linear muffin tin orbital method for calculating the corresponding scattering matrices. PCAR is found to measure the spin-dependent interface transparency rather than the bulk polarization of the ferromagnet which is strongly overestimated by free electron model fitting.Comment: 4 pages, 1figure. submitte

Intense physical activity is associated with cognitive performance in the elderly

Numerous studies have reported positive impacts of physical activity on cognitive function. However, the majority of these studies have utilised physical activity questionnaires or surveys, thus results may have been influenced by reporting biases. Through the objective measurement of routine levels of physical activity via actigraphy, we report a significant association between intensity, but not volume, of physical activity and cognitive functioning. A cohort of 217 participants (aged 60–89 years) wore an actigraphy unit for 7 consecutive days and underwent comprehensive neuropsychological assessment. The cohort was stratified into tertiles based on physical activity intensity. Compared with individuals in the lowest tertile of physical activity intensity, those in the highest tertile scored 9%, 9%, 6% and 21% higher on the digit span, digit symbol, Rey Complex Figure Test (RCFT) copy and Rey Figure Test 30-min recall test, respectively. Statistically, participants in the highest tertile of physical activity intensity performed significantly better on the following cognitive tasks: digit symbol, RCFT copy and verbal fluency test (all P<0.05). The results indicate that intensity rather than quantity of physical activity may be more important in the association between physical activity and cognitive function