13 research outputs found
Expression of Vascular Endothelial Growth Factor by Retinal Pigment Epithelial Cells Induced by Amyloid-� Is Depressed by an Endoplasmic Reticulum Stress Inhibitor
One-Year Outcomes of 1 + pro re nata versus 3 + pro re nata Intravitreal Aflibercept Injection for Neovascular Age-Related Macular Degeneration
Better Visual Outcome by Intraocular Lens Ejection in Geriatric Patients with Ruptured Ocular Injuries
<div><p>Ocular trauma is one of the leading causes of visual impairment worldwide. Because of the popularity of cataract surgeries, aged individuals with ocular trauma commonly have a surgical wound in their eyes. The purpose of this study was to evaluate the visual outcome of cases that were coincident with intraocular lens (IOL) ejection in the eyes with ruptured open-globe ocular injuries. Consecutive patients with open-globe ocular injuries were first reviewed. Patients’ characteristics, corrected distance visual acuities (CDVAs) over 3 years after the trauma, causes of injuries, traumatic wound patterns, and coexistence of retinal detachment were examined. The relationships between poor CDVA and the other factors, including the complications of crystalline lens and IOL ejection, were examined. A total of 105 eyes/patients [43 eyes with rupture, 33 with penetrating, 28 with intraocular foreign body (IOFB), and 1 with perforating injuries] were included. Rupture injuries were common in aged patients and were mostly caused by falls, whereas penetrating and IOFB injuries were common in young male patients. CDVAs of the eyes with rupture injuries were significantly worse than those of the eyes with penetrating or IOFB injuries. CDVA from more than 50% of the ruptured eyes resulted in no light perception or light perception to 20/500. CDVA of the ruptured eyes complicated by crystalline lens ejection was significantly worse than that of those complicated by IOL ejection. The wounds of the ruptured eyes complicated by IOL ejection were mainly located at the superior corneoscleral limbus, whereas those of the eyes complicated by crystalline lens ejection were located at the posterior sclera. There were significant correlations between poor CDVA and retinal detachment and crystalline lens ejection. These results proposed a new trend in the ocular injuries that commonly occur in aged patients; history of cataract surgery might affect the final visual outcome after open-globe ocular injuries.</p></div
Zones of injuries and the number of surgeries.
<p>Zones of injuries and the number of surgeries.</p
Assignment of non-Landolt ring/Snellen acuity into logMAR values.
<p>Assignment of non-Landolt ring/Snellen acuity into logMAR values.</p
The distribution of the ruptured eyes in age.
<p>The distribution of the ruptured eyes in age.</p
Results of multiple stepwise regression analysis for independence of factors contributing to the final logMAR visuals.
<p>Results of multiple stepwise regression analysis for independence of factors contributing to the final logMAR visuals.</p
The difference in the final visual outcome depending on the lens damage.
<p><b>(A)</b> More than 40% of the patients who had IOL ejection, traumatic cataract, or lens dislocation with ruptured ocular injuries showed a visual outcome of 20/400 or better. On the other hand, more than 70% of the patients with crystalline lens ejection had a visual outcome of 20/500 or worse. <b>(B)</b> A significantly better final visual outcome (logMAR) was attained in ruptured eyes complicated by IOL ejection than in those complicated by crystalline lens ejection. *<i>P</i> = 0.048. Error bars indicate whole range of distribution. <b>(C)</b> The wound patterns appeared to be different depending on whether the eyes had a crystalline lens (no history of cataract surgeries) or IOL (history of cataract surgeries). Among 43 ruptured eyes, the eyes complicated by crystalline lens ejection (<i>n</i> = 21) showed traumatic wounds at the corneoscleral limbus and deeper zone of the sclera. In contrast, the traumatic wounds of the eyes complicated by IOL ejection (<i>n</i> = 10) were mostly located only around the corneoscleral limbus. The wounds of the ruptured eyes complicated by traumatic cataract and lens dislocation (no lens/IOL ejection, <i>n</i> = 9) were not located around the corneoscleral limbus. Wounds in the left eyes were projected as a mirror image and sketched on the right eye. IOL, intraocular lens; logMAR, logarithm of the minimum angle of resolution.</p