Continental drift: connecting Great Britain and Scandinavia

Institute of Transport and Logistics Studies. Faculty of Economics and Business. The University of Sydne

Exposure to thioguanine during 117 pregnancies in women with inflammatory bowel disease

Background: Safety of thioguanine in pregnant patients with inflammatory bowel disease [IBD] is sparsely recorded. This study was aimed to document the safety of thioguanine during pregnancy and birth. Methods: In this multicentre case series, IBD patients treated with thioguanine during pregnancy were included. Data regarding disease and medication history, pregnancy course, obstetric complications, and neonatal outcomes were collected. Results: Data on 117 thioguanine-exposed pregnancies in 99 women were collected. Most [78%] had Crohn's disease and the mean age at delivery was 31 years. In 18 pregnancies [15%], IBD flared. Obstetric and infectious complications were seen in 15% [n = 17] and 7% [n = 8] of pregnancies, respectively. Ten pregnancies [8.5%] resulted in a first trimester miscarriage, one in a stillbirth at 22 weeks of gestational age and one in an induced abortion due to trisomy 21. In total, 109 neonates were born from 101 singleton pregnancies and four twin pregnancies. One child was born with a congenital abnormality [cleft palate]. In the singleton pregnancies, 10 children were born prematurely and 10 were born small for gestational age. Screening for myelosuppresion was performed in 16 neonates [14.7%]; two had anaemia in umbilical cord blood. All outcomes were comparable to either the general Dutch population or to data from three Dutch cohort studies on the use of conventional thiopurines in pregnant IBD patients. Conclusion: In this large case series, the use of thioguanine during pregnancy is not associated in excess with adverse maternal or neonatal outcomes.Cellular mechanisms in basic and clinical gastroenterology and hepatolog

Recente ontwikkelingen op het gebied van diabetes mellitus type II op jonge leeftijd (MODY)

Contains fulltext : 21007___.PDF (publisher's version ) (Open Access

Regional hyperinsulinemia does not modulate ß-adrenergic vasodilator action

Contains fulltext : 24778___.PDF (publisher's version ) (Open Access

Problemen bij de interpretatie van het percentage geglyceerd hemoglobine bij patiënten met diabetes mellitus

Contains fulltext : 20925___.PDF (publisher's version ) (Open Access

Decreased HbA1c levels due to sulfonamide-induced hemolysis in two IDDM patients

Contains fulltext : 23657___.PDF (publisher's version ) (Open Access

The twelfth Anglo-Danish-Dutch diabetes group meeting

Contains fulltext : 21356___.PDF (publisher's version ) (Open Access

Kortwerkende insuline-analogen

Contains fulltext : 26166___.PDF (publisher's version ) (Open Access

Cardiovascular effects of insulin: studies in normal and insulin resistant subjects

Contains fulltext : mmubn000001_237863731.pdf (publisher's version ) (Open Access)Promotores : P. Smits, T. Thien, J. Lutterman en J. Lenders184 p