Doença auto-imune de tireóide e urticária crônica idiopática: um estudo caso-controle

Several studies found a higher prevalence of Autoimmune Thyroid Disease (AITD) in patients with Chronic Urticaria (CU). This relationship may be due to the possible autoimmune etiology in up to half of the cases of Chronic Idiopathic Urticaria (CIU). However the frequency of AITD ranged from 1.14% to 28.6%. The study began by determining whether there is an association between AITD and CU, in a population seen at the same clinic. We compare the frequency of anti-thyroid antibodies and thyroid dysfunction in 49 patients with CIU (group 1) and 112 controls (Group 2). In order to support the result found, we studied the prevalence of CIU in 60 patients with AITD (group 3), compared with 29 patients who had non-immune thyroid disease (NAITD) (group 4). We did not find a statistical difference for the presence of anti-thyroid antibodies or thyroid dysfunction between groups 1 and 2. The same occurred for the presence of CIU among groups 3 and 4. In our study it was not possible to demonstrate a relationship between AITD and CIU, which means that different populations may present a higher or lower degree of association between these illnesses.Mestre em Ciências da SaúdeVários estudos encontraram maior prevalência de Doença Auto-imune de Tireóide (DAT) em pacientes com Urticária Crônica (UC). Esta relação pode ocorrer devido a um possível mecanismo patogênico auto-imune que pode estar presente em até metade dos casos de Urticária Crônica Idiopática (UCI). No entanto, a freqüência de DAT variou de 1,14% a 28,6%. O objetivo deste estudo foi determinar se ocorre associação entre DAT e UCI em uma população atendida em um mesmo centro de saúde. Comparou-se a freqüência de anticorpos antitireoidianos e disfunção tireoidiana entre 49 pacientes com UCI (grupo 1) e 112 controles (grupo 2). Com a finalidade de reforçar o resultado encontrado, estudou-se a prevalência de UCI em 60 pacientes com DAT (grupo 3) comparados com 29 pacientes portadores de doença não auto-imune de tireóide (DNAT) (grupo 4). Não se encontrou diferença estatística quanto à presença de anticorpos antitireoidianos ou disfunção tireoidiana entre os grupos 1 e 2. O mesmo ocorreu quanto à presença de UCI entre os grupos 3 e 4. Neste estudo não foi possível demonstrar uma relação entre DAT e UCI ao contrário da maioria dos outros trabalhos relacionados a esse tema. Isto sugere que a associação entre as duas doenças nem sempre ocorre, o que pode parcialmente ser explicado por diferenças nas populações estudadas

Puberty in a sample of Brazilian schoolgirls: timing and anthropometric characteristics

ABSTRACT Objective: The objective of this study was to determine the age at which puberty begins, age of menarche and anthropometric data of the participants at different stages of puberty. Subjects and me thods: This is a cross-sectional study in which we evaluated 665 girls, a sample representing the female schoolchildren population in Uberaba. Results: We found that thelarche, pubarche, underarm hair and menarche were attained at the age of 9.8 ± 1.4, 10.2 ± 1.4, 10.5 ± 1.5 and 11.7 ± 1.3 years, respectively. The mean interval between thelarche and menarche (ITM) was 1.7 ± 1.3 years. The prevalence of overweight and obesity was 31.3% and 95% of the participants began at thelarche between the age of 7 and 12 years. Conclusion: These values indicate a secular tendency to the decrease of the age of menarche and an earlier start of puberty. It is very important to understand these parameters to establish public policies aimed at plans to prevent these early events, especially regarding control of the prevalence of obesity. Arch Endocrinol Metab. 2015;59(2):105-1

Puberty in a sample of Brazilian schoolgirls: timing and anthropometric characteristics

Objective The objective of this study was to determine the age at which puberty begins, age of menarche and anthropometric data of the participants at different stages of puberty. Subjects and methods This is a cross-sectional study in which we evaluated 665 girls, a sample representing the female schoolchildren population in Uberaba. Results We found that thelarche, pubarche, underarm hair and menarche were attained at the age of 9.8 ± 1.4, 10.2 ± 1.4, 10.5 ± 1.5 and 11.7 ± 1.3 years, respectively. The mean interval between thelarche and menarche (ITM) was 1.7 ± 1.3 years. The prevalence of overweight and obesity was 31.3% and 95% of the participants began at thelarche between the age of 7 and 12 years. Conclusion These values indicate a secular tendency to the decrease of the age of menarche and an earlier start of puberty. It is very important to understand these parameters to establish public policies aimed at plans to prevent these early events, especially regarding control of the prevalence of obesity

Primary pigmented nodular adrenocortical disease associated with Carney complex: case report and literature review

CONTEXT: Carney complex (CNC), a familial multiple neoplasm syndrome with dominant autosomal transmission, is characterized by tumors of the heart, skin, endocrine and peripheral nervous system, and also cutaneous lentiginosis. This is a rare syndrome and its main endocrine manifestation, primary pigmented nodular adrenal disease (PPNAD), is an uncommon cause of adrenocorticotropic hormone-independent Cushing's syndrome. CASE REPORT: We report the case of a 20-year-old patient with a history of weight gain, hirsutism, acne, secondary amenorrhea and facial lentiginosis. Following the diagnosing of CNC and PPNAD, the patient underwent laparoscopic bilateral adrenalectomy, and she evolved with decreasing hypercortisolism. Screening was also performed for other tumors related to this syndrome. The diagnostic criteria, screening and follow-up for patients and affected family members are discussed