Data-Driven Structural Health Monitoring in Laminated Composite Structures: Characterisation of Impact Damage

There is a high level of uncertainty for detecting damage, such as barely visible impact damage, hidden manufacturing defects, and subsurface cracks in laminated composites, which is a main limiting factor in wider use of these materials. This highlights the necessity of developing innovative structural health monitoring (SHM) strategies to meet the safety and reliability of current composite structures. In this research, a wide range of laminated composite specimens were designed, manufactured and tested under drop-weight impact with several impact energies to generate visual evidence of such impact events. The dataset was then used to train a user developed artificial intelligence (AI)-based algorithm to identify and predict damaged areas. The results showed that the developed algorithm could well identify the impact damage on both front and back faces of the specimens. The results obtained from the new AI-based platform were in good agreement with visual observations. The research highlights the importance of a high quality dataset in training the AI-based algorithms for visual SHM

Design principles and recent developments in adhesively bonded joints of fibre-reinforced plastic composite structures

Fibre-reinforced plastic (FRP) composite components must be joined such that the overall structure maintains its structural integrity while it is under mechanical and environmental loads. This chapter introduces adhesively bonded joints (ABJs) as a main joining technique of FRP composite structures, their design principles, characterisation methods and recent developments. Advantages and disadvantages of ABJs are discussed and their performance is compared with mechanical joining techniques. Design considerations and effective parameters such as adhesive properties, surface preparation, joint configuration and environmental factors on the joint behaviour are described. Different techniques for characterising ABJs' static and in-service performances such as fatigue and ageing are briefly discussed. A summary of the analytical and numerical methods developed for stress analysis of ABJ is also provided. Novel trends on ABJs, including bio-inspired designs to reduce stress concentration, self-healing and mechanical interlocking, are briefed, given new directions for research and design of ABJ of FRP composite structures

Therapeutic role of curcumin and its novel formulations in gynecological cancers

Gynecological cancers are among the leading causes of cancer-associated mortality worldwide. While the number of cases are rising, current therapeutic approaches are not efficient enough. There are considerable side-effects as well as treatment resistant types. In addition, which all make the treatment complicated for afflicted cases. Therefore, in order to improve efficacy of the treatment process and patients� quality of life, searching for novel adjuvant treatments is highly warranted. Curcumin, a promising natural compound, is endowed with numerous therapeutic potentials including significant anticancer effects. Recently, various investigations have demonstrated the anticancer effects of curcumin and its novel analogues on gynecological cancers. Moreover, novel formulations of curcumin have resulted in further propitious effects. This review discusses these studies and highlights the possible underlying mechanisms of the observed effects. © 2020, The Author(s)

Hippo/MST blocks breast cancer by downregulating WBP2 oncogene expression via miRNA processor Dicer

10.1038/s41419-020-02901-3Cell Death and Disease11866