Radio Echo Sounding (RES) investigations at Talos Dome (East Antarctica): bedrock topography and ice thickness

Radio echo sounding measurements were collected during two Antarctic expeditions to determine the ice thickness and the sub-glacial morphology of Talos Dome in the region around 72°48'S; 159°06'E (about 6400 km2) on the edge of the East Antarctic plateau adjacent to Victoria Land in the western Ross Sea sector. The increasing interest in this region is due to the fact that in this area the ice accumulation is higher than in other sites in East Antarctica. Because of this, Talos Dome could be a new site for a project of a deep ice core drilling to obtain information on climate changes near the coast of Antarctica. In this frame, the knowledge of the bedrock topography is of great importance to choose the best location for the drilling site. In this paper, airborne radio echo sounding results from two Antarctic expeditions (1997 and 1999) are presented. Bedrock topography in bi- and three-dimensions for the Talos Dome region are discussed

Geophysical survey at Talos Dome, East Antarctica: the search for a new deep-drilling site

Talos Dome is an ice dome on the edge of the East Antarctic plateau; because accumulation is higher here than in other domes of East Antarctica, the ice preserves a good geochemical and palaeoclimatic record. A new map of the Talos Dome area locates the dome summit using the global positioning system (GPS) (72˚47’ 14’’S, 159˚04’ 2’’E; 2318.5m elevation (WGS84)). A surface strain network of nine stakes was measured using GPS. Data indicate that the stake closest to the summit moves south-southeast at a few cma–1. The other stakes, located 8 km away, move up to 0.33ma–1. Airborne radar measurements indicate that the bedrock at the Talos Dome summit is about 400m in elevation, and that it is covered by about 1900m of ice. Snow radar and GPS surveys show that internal layering is continuous and horizontal in the summit area (15 km radius). The depth distribution analysis of snow radar layers reveals that accumulation decreases downwind of the dome (north-northeast) and increases upwind (south-southwest). The palaeomorphology of the dome has changed during the past 500 years, probably due to variation in spatial distribution of snow accumulation, driven by wind sublimation. In order to calculate a preliminary age vs depth profile for Talos Dome, a simple one-dimensional steady-state model was formulated. This model predicts that the ice 100m above the bedrock may cover one glacial–interglacial period.Published423-4323.8. Geofisica per l'ambienteJCR Journalreserve

phosphorus and potassium fertilizer effects on alfalfa and soil in a non limited soil

Fertilization strategies for high-yielding alfalfa (Medicago sativa L.) should take in account the increase in soil nutritional status that occurred during the last decades in areas with intensive agricultural use. A field study was conducted at the University of Padova, northeastern Italy, to determine the response of alfalfa yield and nutritive value to various combinations of P and K rates in a soil lacking nutrient deficiency. Alfalfa cultivar Delta was seeded in March 2005 on a silt loam soil having 38 mg kg -1 available P and 178 mg kg -1 exchangeable K. Nine treatments deriving from the combination of three P fertilization rates (0, 100, and 200 kg ha -1 P 2 O 5 ) and three K rates (0, 300, and 600 kg ha -1 K 2 O) were compared in a randomized complete block design. Plots were harvested at bud stage during three growing seasons (2005-2007) and dry matter (DM) yield, forage nutritive value, P and K contents, canopy height, and stem density were measured at each harvest. Soil samples were collected at the end of the research period for determination of available P and exchangeable K. The results demonstrated that P application had no impact on yield and did not interact with K in determining productivity, while K had a positive effect on yield. However, the 300 kg ha -1 K 2 O rate appeared sufficient to maximize yield, without adverse effects on the forage nutritive value. Data from soil analyses showed that alfalfa has a high K uptake even when it is fertilized at high rates

Calcium Citrate Versus Calcium Carbonate in the Management of Chronic Hypoparathyroidism: A Randomized, Double-Blind, Crossover Clinical Trial

In hypoparathyroidism (HypoPT), calcium supplementation is virtually always required, although the disease is likely to be associated with an increased risk of nephrolithiasis. The use of calcium citrate (Ca-Cit) theoretically could have a positive impact on the nephrolithiasis risk because citrate salts are used to reduce this risk. Our objective was to evaluate the potential therapeutic advantage of Ca-Cit in comparison with calcium carbonate (CaCO3) in HypoPT, on nephrolithiasis risk factors, as well as to their ability to maintain desirable serum calcium levels. We also evaluated these preparations on quality of life (QOL). This randomized, double-blind, crossover trial recruited 24 adults with postsurgical chronic hypoparathyroidism at Campus Bio-Medico University of Rome. Participants were randomized 1:1 to Ca-Cit or CaCO3 for 1 month and then crossed over to the other treatment for another month. The primary outcomes were changes in albumin-adjusted serum calcium and in ion activity product of calcium oxalate levels (AP[CaOx] index). Secondary efficacy outcomes included changes in SF-36 survey score, fatigue score, constipation, and adverse events. No difference in terms of AP(CaOx) index was observed between the two groups. However, Ca-Cit was associated with a significant reduction in the oxalate/creatinine ratio compared with CaCO3 (-2.46 mmol/mol [SD 11.93] versus 7.42 mmol/mol [SD 17.63], p = 0.029). Serum calcium and phosphorus concentration was not different between the two calcium preparations. Ca-Cit was associated with less constipation (p = 0.047). No difference was found in QOL scores. Although Ca-Cit did not modify the AP(CaOx) index when compared with CaCO3, it was associated with a reduction in urinary oxalate excretion that could have a potential beneficial effect on nephrolithiasis risk. These results are likely to have clinical implications in HypoPT, particularly those who do not tolerate CaCO3 and those affected by nephrolithiasis. A longer-term experience is needed to confirm these findings. (c) 2022 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR)

Fluorescent carbon dioxide indicators

Over the last decade, fluorescence has become the dominant tool in biotechnology and medical imaging. These exciting advances have been underpinned by the advances in time-resolved techniques and instrumentation, probe design, chemical / biochemical sensing, coupled with our furthered knowledge in biology. Complementary volumes 9 and 10, Advanced Concepts of Fluorescence Sensing: Small Molecule Sensing and Advanced Concepts of Fluorescence Sensing: Macromolecular Sensing, aim to summarize the current state of the art in fluorescent sensing. For this reason, Drs. Geddes and Lakowicz have invited chapters, encompassing a broad range of fluorescence sensing techniques. Some chapters deal with small molecule sensors, such as for anions, cations, and CO2, while others summarize recent advances in protein-based and macromolecular sensors. The Editors have, however, not included DNA or RNA based sensing in this volume, as this were reviewed in Volume 7 and is to be the subject of a more detailed volume in the near future

Comparison of smoking, drinking, and marijuana use between students present or absent on the day of a school-based survey

ABSTRACT: The aim of this population-based survey was to compare the prevalence of selected risk behaviors between students present or absent on the day of a school-based survey. The study population was a representative sample of all students of secondary schools in the Seychelles (Indian Ocean). Students absent on the day of the survey were traced and requested to complete the same self-administered questionnaire as did present students. Self-reported consumption of cigarettes, alcohol, and marijuana were measured. Of the sample of 1453 eligible students aged 11 to 17 years, 1321 ''present students'' completed the survey (90.9% participation), 11 refused to answer all questions, and 121 were not present at school. We could trace 105 of the 121 students not present at school on the survey day (''absent students''), and all of them completed the questionnaire over the next 4 weeks. The prevalence of risk behaviors was significantly higher in absent than present students for current smoking and drinking. Inclusion of data from the absent students resulted in a relative increase in the prevalence of the considered behaviors by 3% to 8% as compared to data based on present students only. In conclusion, the prevalence of risk behaviors was higher in absent than present students. Adjusting for data of absent students increased the prevalence estimates in the base population. [Authors]]]> eng oai:serval.unil.ch:BIB_32B4B43F6575 2022-05-07T01:14:38Z <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_32B4B43F6575 International Perspectives in industrialized countries: where do we stand on the measurement of the quality of care and patient safety ? Januel, J.M. info:eu-repo/semantics/other booklet 2015 eng oai:serval.unil.ch:BIB_32B51818A8DB 2022-05-07T01:14:38Z openaire documents <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_32B51818A8DB “I thought you were okay”: Participatory Design with Young Adults to Fight Multiparty Privacy Conflicts in Online Social Networks info:doi:10.1145/3461778.3462040 info:eu-repo/semantics/altIdentifier/doi/10.1145/3461778.3462040 Salehzadeh Niksirat, Kavous Anthoine-Milhomme, Evanne Randin, Samuel Huguenin, Kévin Cherubini, Mauro info:eu-repo/semantics/conferenceObject inproceedings 2021-06 Proceedings of the Designing Interactive Systems Conference (DIS) eng info:eu-repo/grantAgreement/SNF/Projects/190762/// https://serval.unil.ch/resource/serval:BIB_32B51818A8DB.P001/REF.pdf http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_32B51818A8DB5 info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_32B51818A8DB5 info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/openAccess CC BY-NC-ND 4.0 https://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf oai:serval.unil.ch:BIB_32B5D292A794 2022-05-07T01:14:38Z <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_32B5D292A794 Evolutionary Graph Models with Dynamic Topologies on the Ubichip Peña, J. C. Peña, J. Upegui, A. info:eu-repo/semantics/conferenceObject inproceedings 2008 ICES 2008, LNCS 5216, pp. 59-70 Gregory S. Hornby, (ed.) Lukas, Sekanina (ed.) Pauline C. Haddow, (ed.) eng oai:serval.unil.ch:BIB_32B62D0D1860 2022-05-07T01:14:38Z <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_32B62D0D1860 Vaccination with a Melan-A peptide selects an oligoclonal T cell population with increased functional avidity and tumor reactivity. info:eu-repo/semantics/altIdentifier/pmid/11937585 Valmori, D. Dutoit, V. Schnuriger, V. Quiquerez, A.L. Pittet, M.J. Guillaume, P. Rubio-Godoy, V. Walker, P.R. Rimoldi, D. Liénard, D. Cerottini, J.C. Romero, P. Dietrich, P.Y. info:eu-repo/semantics/article article 2002 Journal of Immunology, vol. 168, no. 8, pp. 4231-4240 info:eu-repo/semantics/altIdentifier/pissn/0022-1767 urn:issn:0022-1767 <![CDATA[Both the underlying molecular mechanisms and the kinetics of TCR repertoire selection following vaccination against tumor Ags in humans have remained largely unexplored. To gain insight into these questions, we performed a functional and structural longitudinal analysis of the TCR of circulating CD8(+) T cells specific for the HLA-A2-restricted immunodominant epitope from the melanocyte differentiation Ag Melan-A in a melanoma patient who developed a vigorous and sustained Ag-specific T cell response following vaccination with the corresponding synthetic peptide. We observed an increase in functional avidity of Ag recognition and in tumor reactivity in the postimmune Melan-A-specific populations as compared with the preimmune blood sample. Improved Ag recognition correlated with an increase in the t(1/2) of peptide/MHC interaction with the TCR as assessed by kinetic analysis of A2/Melan-A peptide multimer staining decay. Ex vivo analysis of the clonal composition of Melan-A-specific CD8(+) T cells at different time points during vaccination revealed that the response was the result of asynchronous expansion of several distinct T cell clones. Some of these T cell clones were also identified at a metastatic tumor site. Collectively, these data show that tumor peptide-driven immune stimulation leads to the selection of high-avidity T cell clones of increased tumor reactivity that independently evolve within oligoclonal populations

Corrigendum to: Comparative study of obstetric antiphospholipid syndrome (OAPS) and non-criteria obstetric APS (NC-OAPS): report of 1640 cases from EUROAPS registry

Rheumatology 2020;59:1306–1314. doi:https://doi.org/10.1093/rheumatology/kez419 In the original article, the affiliation of co-author Cecilia Beatrice Chighizola should have read: “Experimental Laboratory of Immunological and Rheumatologic Researches, Istituto Auxologico Italiano, IRCCS, Cusano Milanino, Milan, Italy”. These details have been corrected only in this corrigendum to preserve the published version of record