A review of the phytochemistry and pharmacological activities of Raphani Semen

Author name used in this publication: Daniel Kam-Wah Mok2012-2013 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

VEGF, FGF1, FGF2 and EGF gene polymorphisms and psoriatic arthritis

BACKGROUND: Angiogenesis appears to be a first-order event in psoriatic arthritis (PsA). Among angiogenic factors, the cytokines vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), and fibroblast growth factors 1 and 2 (FGF1 and FGF2) play a central role in the initiation of angiogenesis. Most of these cytokines have been shown to be upregulated in or associated with psoriasis, rheumatoid arthritis (RA) or ankylosing spondylitis (AS). As these diseases share common susceptibility associations with PsA, investigation of these angiogenic factors is warranted. METHODS: Two hundred and fifty-eight patients with PsA and 154 ethnically matched controls were genotyped using a Sequenom chip-based MALDI-TOF mass spectrometry platform. Four SNPs in the VEGF gene, three SNPs in the EGF gene and one SNP each in FGF1 and FGF2 genes were evaluated. Statistical analysis was performed using Fisher's exact test, and the Cochrane-Armitage trend test. Associations with haplotypes were estimated by using weighted logistic models, where the individual haplotype estimates were obtained using Phase v2.1. RESULTS: We have observed an increased frequency in the T allele of VEGF +936 (rs3025039) in control subjects when compared to our PsA patients [Fisher's exact p-value = 0.042; OR 0.653 (95% CI: 0.434, 0.982)]. Haplotyping of markers revealed no significant associations. CONCLUSION: The T allele of VEGF in +936 may act as a protective allele in the development of PsA. Further studies regarding the role of pro-angiogenic markers in PsA are warranted

Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations

Osteoarthritis affects over 300 million people worldwide. Here, we conduct a genome-wide association study meta-analysis across 826,690 individuals (177,517 with osteoarthritis) and identify 100 independently associated risk variants across 11 osteoarthritis phenotypes, 52 of which have not been associated with the disease before. We report thumb and spine osteoarthritis risk variants and identify differences in genetic effects between weight-bearing and non-weight-bearing joints. We identify sex-specific and early age-at-onset osteoarthritis risk loci. We integrate functional genomics data from primary patient tissues (including articular cartilage, subchondral bone, and osteophytic cartilage) and identify high-confidence effector genes. We provide evidence for genetic correlation with phenotypes related to pain, the main disease symptom, and identify likely causal genes linked to neuronal processes. Our results provide insights into key molecular players in disease processes and highlight attractive drug targets to accelerate translation

Regeneration of nucleus pulposus cells for degenerative disc disorder

Oral Presentations: Session 3 - Reproduction & Development and Public Health: 3.1

Regeneration of nucleus pulposus cells for Degenerative Disc Disorder

Symposium in Honor of Patrick Tam FRS "60 Years & Still Gastrulating"Conference Theme: From Embryology to Disease Mechanism

Regeneration of the nucleus pulposus cells for Degenerative Disc Disorder

Conference Theme: Cartilage: Formation, Structure, Function, and Regeneratio

Regeneration of nucleus pulposus cells for degenerative disc disorder

Poster Presentation - Theme 1: Cell Biology, Musculoskeletal System, Reproduction & Development: 1.16The 16th Research Postgraduate Symposium (RPS 2011), the University of Hong Kong, Hong Kong, 7-8 December 2011

A review on the traditional Chinese medicinal herbs and formulae with hypolipidemic effect

2013-2014 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Cholesterol-lowering effects of piceatannol, a stilbene from wine, using untargeted metabolomics

202308 bckwAccepted ManuscriptRGCOthersHong Kong Chinese Material Medica Standards Project; Shenzhen Basic Research Program; National Natural Science Foundation of China; Large Equipment Funds, PolyUPublishe

Chemical analysis of astragali Complanati semen and its hypocholesterolemic effect using serum metabolomics based on gas chromatography-mass spectrometry

2017-2018 > Academic research: refereed > Publication in refereed journal201802 bcrcVersion of RecordPublishe