VITAMIN C AND ITS ROLE IN BODY

Ascorbic acid or Vitamin C is very important in our body because of its antioxidant property. But the main problem; that vitamin C uses is to maintain the stability as well as its drug distribution system. Vitamin C also plays a protective role in diabetes, cancer, heavy metal toxicity or poisoning, etc. Vitamin C is found in many sources present in nature, including tomatoes, broccoli, etc. Many factors in the body, as well as outside the body, affect the content of vitamin C in the body or sources like the season, climate, and pollution affect the content in fruits and vegetables besides sex, age, pregnancy, lactation, etc. affect the vitamin C content in the body. It is extensively used in the common cold, wound healing process, cancer, heavy metal poisoning or toxicity, and even in men's fertility. In this article, we focused on the general aspects: its bioavailability, sources, its toxicity and deficiency, and factors affecting vitamin C level as well as its use in humans. In the last, we conclude, the excess or lack of Vitamin C, both conditions have affected the human body in a significant range. It plays a protective role against many disorders and is required for kids, men, women, and even old-aged patients

A New 3D 10-Connected Cd(II) Based MOF With Mixed Ligands: A Dual Photoluminescent Sensor for Nitroaroamatics and Ferric Ion

The precise unification of functional groups and photoluminescence properties can give rise to MOFs that can offer diverse applications like selective detection of nitroaromatic compounds (NACs) which are considered to be an important ingredient of explosive as well as cation and anion sensing. Hence, a new 3D metal-organic framework (MOF) [Cd2(btc)(bib)(HCOO)(H2O)·H2O]n (1) has been synthesized using mixed ligand strategy by solvothermal reaction of cadmium acetate with two ligands viz. 1,3,5-benzenetricarboxylic acid (H3btc) and 1,4-bis(2-methyl-imidazol-1-yl)butane (bib). The MOF 1 possesses highly 10-connected network which is based on {Cd4(btc)2(bib)4} molecular building block. The studies showed that 1 could be taken as the fluorescent sensor for sensitive recognition of NACs, in particular 2,4,6-trinitrophenol (TNP) with notable quenching (Ksv = 5.42 × 104 M−1) and LOD of 1.77 ppm. Additionally, 1 also displayed selective sensing for Fe3+ ions with Ksv = 6.05 × 103 M− 1 and LOD = 1.56 ppm. Also, this dual sensor displayed excellent reusability toward the detection of TNP and Fe3+ ion. Theoretical calculations have been performed to propose the probable mechanism for the sensing luminescence intensity. Calculations indicated that because of the charge transfer and weak interaction that is operating between NACs and MOF, the weakening in the photoluminescence intensity resulted

Ferrocenylethenyl-substituted oxadiazoles with phenolic and nitro anchors as sensitizers in dye sensitized solar cells

Three new ferrocenyl oxadiazoles, viz. (E)-2-(4-hydroxyphenyl)-5-(2-ferrocenyl-ethen-1-yl)-1,3,4-oxadiazole (D2), (E)-2-(4-nitrophenyl)-5-(2-ferrocenyl-ethen-1-yl)-1,3,4-oxadiazole (D3) and (E)-3-(4-nitrophenyl)-5-[5-(2-ferroceneylethen-1-yl)-1,3,4-oxadiazol-2-yl]-1,2,4-oxadiazole (D4) derived from (E)-3-ferrocenylacrylic acid (D1) having phenolic or nitro anchors, have been synthesized and characterized using microanalyses and relevant spectroscopic techniques. UV-Vis spectroscopic studies indicate that with respect to ferrocene, the electronic absorption bands of the new compounds are bathochromically shifted up to 600 nm with a concomitant enhancement in their intensities. All four compounds have been used as photosensitizers in TiO 2 -based dye-sensitized solar cells (DSSCs). The photovoltaic performances and charge transport properties (EIS spectra) of these compounds were studied to appraise their dye performance. All four compounds displayed good photovoltaic performances. However, compounds D2 and D4 displayed superior performance, which might be due to the better electronic communication between the ferrocenyl moiety and the six membered aromatic ring with their -OH/NO 2 anchors having five membered oxadiazole spacers, as well as the high dye loading of these compounds on the TiO 2 surface, which suppresses charge recombination, prolongs electron lifetime, and decreases the total resistance of DSSCs. The assembly fabricated using D4 performed better with an overall conversion efficiency η of 4.70%, J sc of 10.33 mA cm -2 and V oc of -0.712 V. </p

Effect of bioadhesion on initial in vitro buoyancy of effervescent floating matrix tablets of ciprofloxacin HCL

The purpose of this study was to investigate effect of bioadhesion on the initial in vitro buoyancy behaviour of effervescent matrix tablets of ciprofloxacin HCl (CIPRO). Tablets were prepared by direct compression using HPMC K4M and Carbopol 971P as hydrophilic-controlled release polymers, sodium bicarbonate (NaHCO3) as gas-generating agent, polyplasdone XL, Explotab and Ac-Di-Sol as swelling agents. Tablets were evaluated for normal and modified initial in vitro floating behavior, floating duration, swelling behavior and in vitro drug release studies. A modified buoyancy lag time for tablets was determined in order to include the effect of bioadhesion on initial buoyancy. The initial buoyancy was found depended on bioadhesion ability of tablets. The lowest modified buoyancy lag time of 20 seconds was obtained for Formulation F7 having both NaHCO3 and polyplasdone XL. The floating duration was also found dependent on concentration of NaHCO3 and swelling agents. The drug release of F7 was also sustained up to 12-hr duration with anomalous drug transport mechanism

Human resource management in the retail sector: challenges and trends

This article explores the challenges and trends in human resource management across the retail sector in India. The focus is on how retailers are coming to terms with wider recruitment patterns and skills sets, and how they are adapting their HR policies to suit these changes. The article also considers what this means for hiring managers in the future. Some of the challenges that Indian retailers face include finding people with experience in all of their stores; dealing with labour shortages when employees retire or become ill; attracting skilled staff, who have been displaced by automation, to work in retail; retaining staff by providing better opportunities for them to progress through training or promotion within a company; and retaining older workers so they do not leave at an age which is too early. It is argued that the retail sector has to recognize that a key function of HR is being prepared for future changes, in order to survive and flourish

Supramolecular architecture of organotin(IV) N-methyl ferrocenyl N-ethanol dithiocarbamates: Crystallographic and computational studies

Four new organotin(IV) ferrocenyl dithiocarbamate complexes viz. (FcCH(2)EtOHdtc)(2)SnR2] (R = Me (1), n-Bu (2) and Ph (3)) and (FcCH(2)EtOHdtc) SnPh3] (4) have been synthesized and characterized by electronic absorption, IR, H-1, C-13 and Sn-119 NMR spectroscopy. The molecular structures of 1 and 2 have been confirmed by single crystal X-ray diffraction technique. The X-ray analyses for 1 and 2 reveal a skew trapezoidal bipyramid geometry around Sn(IV) which is being satisfied by the two sulfur atoms of the two dithiocarbamate ligands in anisobidentate fashion. In the crystal structure of 1, an interesting one dimensional chain held by O-H center dot center dot center dot O intermolecular interactions and also display weak C-H center dot center dot center dot pi and C-H center dot center dot center dot S interactions. The crystal structure of 2 exhibit the formation of one dimensional chain held by weak O-H center dot center dot center dot S, (Cp) C-H center dot center dot center dot O and pi center dot center dot center dot pi interactions. Additionally 2 also display the formation of one dimensional chain because of the (Cp) C-H center dot center dot center dot S and (Cp) C-H center dot center dot center dot pi interactions. These interactions have been addressed by ab initio and atoms-in-molecules analyses. (C) 2017 Elsevier B.V. All rights reserved