Dislessia, disgrafia e didattica inclusiva

L'articolo presenta un orientamento di ricerca sui Disturbi Specifici di Apprendimento affrontabili con il contributo delle nuove tecnologie

Disabilità e formazione del sé nell'autobiografia

Autobiographical narration has recently become a peculiar object of study. This volume uses the autobiographical device in its formative value in the process of building the self through the narration of childhood, in the formation of identity in disabled people and as a tool in the analysis of the relationship between parents and children with disabilities. Through the autobiographical paths outlined in the text by way of example, the narration qualifies as an educational tool both for the narrator and for the reader. In fact, while for the narrator writing assumes an important cathartic role, for the reader it becomes a means of consolidating the professional skills aimed at accompanying those in training, disabled or not, in the construction of a life project

Il recupero del sé attraverso l'autobiografia

An accurate definition of memory would embarrass any serious scholar. Briefly, memory could be defined as a wonderful mechanism, a way to transport us back in time. Memory is therefore a mental activity that binds us over time, it is what gives meaning to the existence. Self-narration or autobiography means first of all asking oneself about the status of one's own identity, it means communication, communicating to ourselves and to others who we are; it means transforming the interior monologue into dialogue with otherness; it means marking and regulating our emotions through the representation of the events of our life

A rational approach to elucidate human monoamine oxidase molecular selectivity

Designing highly selective human monoamine oxidase (hMAO) inhibitors is a challenging goal on the road to a more effective treatment of depression and anxiety (inhibition of hMAO-A isoform) as well as neurodegenerative diseases (inhibition of hMAO-B isoform). To uncover the molecular rationale of hMAOs selectivity, two recently prepared 2H-chromene-2-ones, namely compounds 1 and 2, were herein chosen as molecular probes being highly selective toward hMAO-A and hMAO-B, respectively. We performed molecular dynamics (MD) studies on four different complexes, cross-simulating one at a time the two hMAO-isoforms (dimer embedded in a lipid bilayer) with the two considered probes. Our comparative analysis on the obtained 100 ns trajectories discloses a stable H-bond interaction between 1 and Gln215 as crucial for ligand selectivity toward hMAO-A whereas a water-mediated interaction might explain the observed hMAO-B selectivity of compound 2. Such hypotheses are further supported by binding free energy calculations carried out applying the molecular mechanics generalized Born surface area (MM-GBSA) method and allowing us to evaluate the contribution of each residue to the observed isoform selectivity. Taken as whole, this study represents the first attempt to explain at molecular level hMAO isoform selectivity and a valuable yardstick for better addressing the design of new and highly selective MAO inhibitors

Il recupero del sé attraverso l'autobiografia

The request for a precise definition of memory would put any serious academic into difficulty. To provide a synthetic response, we could define memory as a marvellous mechanism, a means for taking us back in time. Memory is, therefore, a mental activity which connects us over time and gives a meaning to existence. Telling one's story, one's autobiography, signifies primarily taking stock of the state of one's own identity; it signifies communication, communicating who we are to ourselves and others. It means transforming the interior monologue into dialogue with the other; it means scanning and modulating our emotions through the representation of the events of our lives