‘A very high price to pay?’: Transforming rehabilitation and short prison sentences for women

Significant increases to the prison population in England and Wales during the last twenty years have generated concerns about the over-use of imprisonment, particularly for women and those serving a short sentence. In 2010, major changes to the criminal justice system were proposed by the coalition government, including the introduction of new Community Rehabilitation Companies (CRCs) and a ‘Payment by Results’ (PbR) scheme whereby financial rewards are given for reducing levels of reoffending (MoJ, 2010; 2013h; 2013i). Other significant developments in the new Transforming Rehabilitation (TR) agenda (MoJ, 2013h; 2013i) include the introduction of resettlement prisons, “through the gate” services and statutory supervision for short sentence prisoners after release. Drawing from the findings of an interview survey of twenty-five short sentence women prisoners and prison staff, this chapter provides an overview of the short term imprisonment of women in England and Wales.1 Key areas of the TR reforms are explored and the chapter concludes by considering the risks and opportunities they may present for women sentenced to, or eligible for, a short prison sentence

The Law of Contract Modifications: The Uncertain Quest for a Bench Mark of Enforceability

The law of contract modifications poses an analytical paradox: Modifications should be presumptively invalid because they may encourage extortionary, coercive, opportunistic or monopolistic behaviour. Modifications should be presumptively valid because they represent the parties\u27 assessment of their own best interests. A summary of the case-law reveals theoretical difficulties in the tests of enforceability. The authors use an economic framework of analysis in which they argue that the law of contract modification may be used to minimize the costs of contracting. Dynamic efficiency considerations argue against enforcement of all modifications although static efficiency considerations point in the opposite direction. The potential for opportunistic behaviour and moral hazard problems suggest some variables that are relevant to formulating legal rules which will aid in reducing the long-run costs of contracting

The Law of Contract Modifications: The Uncertain Quest for a Bench Mark of Enforceability

The law of contract modifications poses an analytical paradox: Modifications should be presumptively invalid because they may encourage extortionary, coercive, opportunistic or monopolistic behaviour. Modifications should be presumptively valid because they represent the parties\u27 assessment of their own best interests. A summary of the case-law reveals theoretical difficulties in the tests of enforceability. The authors use an economic framework of analysis in which they argue that the law of contract modification may be used to minimize the costs of contracting. Dynamic efficiency considerations argue against enforcement of all modifications although static efficiency considerations point in the opposite direction. The potential for opportunistic behaviour and moral hazard problems suggest some variables that are relevant to formulating legal rules which will aid in reducing the long-run costs of contracting

A more promising architecture? Commissioners’ perspectives on the reconfiguration of personality disorder services under the Offender Personality Disorder (OPD) pathway

Purpose – This paper explores the views of NHS England (NHSE) and Her Majesty’s Prison and Probation Service (HMPPS) commissioners about the Offender Personality Disorder (OPD) pathway. Design/methodology/approach – Thematic analysis of four semi-structured interviews with NHSE and HMPPS commissioners. Findings – Commissioners offered a cautious but confident assessment of the potential effectiveness of the OPD pathway, drawing particular attention to its potential to enhance the confidence and competency of staff, offer better value for money and provide enhanced progression routes for offenders with personality disorders. Additionally, commissioners identified a number of potential risks for the pathway including wider system flux, funding availability, multi-agency working, offender engagement and the need to evidence effectiveness. Research limitations/implications – Our analysis is based on a small number of interviews. However, there are only a limited number of commissioners involved with the OPD pathway. Practical implications – While the stronger focus on progression in the OPD pathway is a welcome departure from a narrow focus on high security DSPD services, the foundations of the OPD pathway ultimately lie with the DSPD programme and similar challenges are likely to follow. The system within which the pathway operates is subject to a great deal of flux and this inevitably poses significant challenges for pathway services, staff and offenders, as well as for those of us charged with its evaluation. Originality/value – There has been limited empirical work with commissioners in the mental health field. Our paper offers a unique insight into the perspectives of those responsible for commissioning the OPD pathway

Persistent punishment : users views of short prison sentences

Semi-structured interviews were conducted of 22 prisoners to gather information about the characteristic features of short prison sentences. Themes raised in comments included: the frequency and quality of sentences, addiction, family, and penal legitimacy. Most of the participants had extensive experience of prison, and the effects of this played out across sentences and years, accumulating and amplifying impacts. And, despite expressions of guilt and remorse, most participants saw their sentence as unjust, and mainly a reaction to offending history. We conclude by suggesting the need for research to shift focus from evaluating individual penal interventions towards more holistic and narrative accounts that cut across sentences

The Role of Polar Pili in the Adherence of Pseudomonas Aeruginosa to Injured Canine Tracheal Cells: A Semiquantitative Morphologic Study

Pseudomonas aeruginosa adheres to respiratory epithelial cells in a highly specific fashion. In order to study the role of P. aeruginosa polar pili in the adherence process we conducted a quantitative morphological electron microscopic examination of P. aeruginosa adherence to SO2 injured canine tracheal cells in vitro. A pilin lacking background strain of P. aeruginosa PAK (BLP2) was constructed using a gene replacement and it in turn was engineered to express either the pilin gene of P. aeruginosa PAO, PAK , or no pilin gene . After 30 minutes incubation of these bacterial strains with injured canine tracheal rings the P. aeruginosa strains expressing pili adhered quantitatively more to the injured tracheal cells than did the pili lacking strains. PAO bearing strains adhered in greater numbers than PAK bearing strains. Healthy tracheal cells did not have any bacteria bound to their surfaces. The bacteria bound to the cilia and lateral edge of the exfoliating tracheal cells. Invasion of tracheal cells by piliated P. aeruginosa bacteria and penetration into the submucosa was also demonstrated. These data confirm the role of pili as important adhesins to injured tracheal cells. The difference in the adherence characteristics of pilin types PAK versus PAO may relate to the differences in the primary structure of these two pilin molecules

Dual targeting of the epigenome via FACT complex and histone deacetylase is a potent treatment strategy for DIPG

Diffuse intrinsic pontine glioma (DIPG) is an aggressive and incurable childhood brain tumor for which new treatments are needed. CBL0137 is an anti-cancer compound developed from quinacrine that targets facilitates chromatin transcription (FACT), a chromatin remodeling complex involved in transcription, replication, and DNA repair. We show that CBL0137 displays profound cytotoxic activity against a panel of patient-derived DIPG cultures by restoring tumor suppressor TP53 and Rb activity. Moreover, in an orthotopic model of DIPG, treatment with CBL0137 significantly extends animal survival. The FACT subunit SPT16 is found to directly interact with H3.3K27M, and treatment with CBL0137 restores both histone H3 acetylation and trimethylation. Combined treatment of CBL0137 with the histone deacetylase inhibitor panobinostat leads to inhibition of the Rb/E2F1 pathway and induction of apoptosis. The combination of CBL0137 and panobinostat significantly prolongs the survival of mice bearing DIPG orthografts, suggesting a potential treatment strategy for DIPG