29 research outputs found
Enquête Ethnobotanique Des Plantes Utilisées Pour La Protection Cutanée Des Personnes Atteintes D’albinisme Dans Le District De Bamako (Mali) Et Analyse Qualitative De Bixa Orellana L. (Bixaceae)
Objectif : Cette étude avait pour objectif de recenser les plantes médicinales utilisées pour la protection cutanée des personnes atteintes d’albinisme, dans le district de Bamako (Mali). Matériel et méthodes : A l’aide d’un questionnaire, des informations ont été collectées auprès des membres d’a associations des personnes atteintes d’albinisme. Les plantes les plus citées ont été soumis à une revue bibliographique. Les constituants chimiques et antiradicalaires des graines de Bixa orellana ont été déterminés par les caractérisations en tubes et par la chromatographie sur couche mince. Résultats : Au total, Dix-neuf (19) plantes médicinales ont été recensées auprès de 75 personnes atteintes d’albinisme et sont principalement utilisées dans la protection cutanée. Les plantes les plus fréquemment citées ont été Khaya senegalensis (12 citations), Guiera senegalensis (10 citations), Bixa orellana (8 citations) et Vitellaria paradoxa (5 citations). Les caroténoïdes, les mucilages, les stérols, les triterpènes et les substances antiradicalaires ont été caractérisés dans les extraits des graines de Bixa orellana. Conclusion : Ces extraits peuvent servir à la formulation de produits qui vont contribuer à la photoprotection, l’hydratation et la protection cutanée des personnes atteintes d’albinisme.
Objective: The objective of this study was to identify medicinal plants used for the skin protection of people with albinism, in the district of Bamako (Mali). Material and methods: Information was collected from members of associations of people with albinism using a questionnaire. The most cited plants were subjected to a bibliographic review. The chemical and anti-free radical components of Bixa orellana seeds were determined by color reactions and by thin layer chromatography. Results: In total, nineteen (19) medicinal plants were identified among 75 people with albinism and are mainly used in skin protection. The most frequently mentioned plants were Khaya senegalensis (12 citations), Guiera senegalensis (10), Bixa orellana (8) and Vitellaria paradoxa (5). Carotenoids, mucilages, sterols, triterpenes and antifree radicals components have been characterized in extracts from the seeds of Bixa orellana. Conclusion: These extracts can be used to formulate products that will contribute to photoprotection, hydration and skin protection for people with albinism. 
The global retinoblastoma outcome study : a prospective, cluster-based analysis of 4064 patients from 149 countries
DATA SHARING : The study data will become available online once all analyses are complete.BACKGROUND : Retinoblastoma is the most common intraocular cancer worldwide. There is some evidence to suggest that major differences exist in treatment outcomes for children with retinoblastoma from different regions, but these differences have not been assessed on a global scale. We aimed to report 3-year outcomes for children with retinoblastoma globally and to investigate factors associated with survival. METHODS : We did a prospective cluster-based analysis of treatment-naive patients with retinoblastoma who were diagnosed between Jan 1, 2017, and Dec 31, 2017, then treated and followed up for 3 years. Patients were recruited from 260 specialised treatment centres worldwide. Data were obtained from participating centres on primary and additional treatments, duration of follow-up, metastasis, eye globe salvage, and survival outcome. We analysed time to death and time to enucleation with Cox regression models. FINDINGS : The cohort included 4064 children from 149 countries. The median age at diagnosis was 23·2 months (IQR 11·0–36·5). Extraocular tumour spread (cT4 of the cTNMH classification) at diagnosis was reported in five (0·8%) of 636 children from high-income countries, 55 (5·4%) of 1027 children from upper-middle-income countries, 342 (19·7%) of 1738 children from lower-middle-income countries, and 196 (42·9%) of 457 children from low-income countries. Enucleation surgery was available for all children and intravenous chemotherapy was available for 4014 (98·8%) of 4064 children. The 3-year survival rate was 99·5% (95% CI 98·8–100·0) for children from high-income countries, 91·2% (89·5–93·0) for children from upper-middle-income countries, 80·3% (78·3–82·3) for children from lower-middle-income countries, and 57·3% (52·1-63·0) for children from low-income countries. On analysis, independent factors for worse survival were residence in low-income countries compared to high-income countries (hazard ratio 16·67; 95% CI 4·76–50·00), cT4 advanced tumour compared to cT1 (8·98; 4·44–18·18), and older age at diagnosis in children up to 3 years (1·38 per year; 1·23–1·56). For children aged 3–7 years, the mortality risk decreased slightly (p=0·0104 for the change in slope). INTERPRETATION : This study, estimated to include approximately half of all new retinoblastoma cases worldwide in 2017, shows profound inequity in survival of children depending on the national income level of their country of residence. In high-income countries, death from retinoblastoma is rare, whereas in low-income countries estimated 3-year survival is just over 50%. Although essential treatments are available in nearly all countries, early diagnosis and treatment in low-income countries are key to improving survival outcomes.The Queen Elizabeth Diamond Jubilee Trust and the Wellcome Trust.https://www.thelancet.com/journals/langlo/homeam2023Paediatrics and Child Healt
Suba
Non-Malian vocal style and multilayered singing accompanied by traditional Malian instuments played with a modern edg
Yaafa N'ma
Non-Malian vocal style and multilayered singing accompanied by traditional Malian instuments played with a modern edg
Kana Neni
Non-Malian vocal style and multilayered singing accompanied by traditional Malian instuments played with a modern edg
Wanita
Non-Malian vocal style and multilayered singing accompanied by traditional Malian instuments played with a modern edg
Muso Niyalen
Non-Malian vocal style and multilayered singing accompanied by traditional Malian instuments played with a modern edg
Mancipera
Non-Malian vocal style and multilayered singing accompanied by traditional Malian instuments played with a modern edg
Yere Oulo
Non-Malian vocal style and multilayered singing accompanied by traditional Malian instuments played with a modern edg
Chateau de Sable
Non-Malian vocal style and multilayered singing accompanied by traditional Malian instuments played with a modern edg