14 research outputs found
Generation of Induced Pluripotent Stem Cells from the Prairie Vole
The vast majority of animals mate more or less promiscuously. A few mammals, including humans, utilize more restrained mating strategies that entail a longer term affiliation with a single mating partner. Such pair bonding mating strategies have been resistant to genetic analysis because of a lack of suitable model organisms. Prairie voles are small mouse-like rodents that form enduring pair bonds in the wild as well as in the laboratory, and consequently they have been used widely to study social bonding behavior. The lack of targeted genetic approaches in this species however has restricted the study of the molecular and neural circuit basis of pair bonds. As a first step in rendering the prairie vole amenable to reverse genetics, we have generated induced pluripotent stem cell (IPSC) lines from prairie vole fibroblasts using retroviral transduction of reprogramming factors. These IPSC lines display the cellular and molecular hallmarks of IPSC cells from other organisms, including mice and humans. Moreover, the prairie vole IPSC lines have pluripotent differentiation potential since they can give rise to all three germ layers in tissue culture and in vivo. These IPSC lines can now be used to develop conditions that facilitate homologous recombination and eventually the generation of prairie voles bearing targeted genetic modifications to study the molecular and neural basis of pair bond formation
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Phase locking of a semiconductor double-quantum-dot single-atom maser
We experimentally study the phase stabilization of a semiconductor double-quantum-dot (DQD) single-atom maser by injection locking. A voltage-biased DQD serves as an electrically tunable microwave frequency gain medium. The statistics of the maser output field demonstrate that the maser can be phase locked to an external cavity drive, with a resulting phase noise L = -99 dBc/Hz at a frequency offset of 1.3 MHz. The injection locking range, and the phase of the maser output relative to the injection locking input tone are in good agreement with Adler’s theory. Furthermore, the electrically tunable DQD energy level structure allows us to rapidly switch the gain medium on and off, resulting in an emission spectrum that resembles a frequency comb. The free running frequency comb linewidth is approximate to 8 kHz and can be improved to less than 1 Hz by operating the comb in the injection locked regime
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On-Chip Quantum-Dot Light Source for Quantum-Device Readout
We use microwave radiation generated by a semiconductor double-quantum-dot (DQD) micromaser for charge-state detection. A cavity is populated with n(c) similar to 6000 photons by driving a current through an emitter DQD. These photons are used to sense the charge state of a target DQD that is located at the opposite end of the cavity. The charge dynamics in the target DQD influences the output power and emission frequency of the maser. Three different readout mechanisms are compared. The detection scheme requires no cavity input field and may potentially be used to improve the scalability of semiconductor and superconducting qubit readout technologies
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Fast Charge Sensing of a Cavity-Coupled Double Quantum Dot Using a Josephson Parametric Amplifier
We demonstrate fast readout of a double quantum dot (DQD) that is coupled to a superconducting resonator. Utilizing a parametric amplifier beyond its range of linear amplification, we improve the signal-to-noise ratio (SNR) by a factor of 2000 compared to the situation with the parametric amplifier turned off. With an integration time of 400 ns comparable to the inverse effective bandwidth, we achieve a SNR of 76. By measuring the SNR as a function of the integration time, we extract an equivalent charge sensitivity of 8 x 10(-5) e/root Hz. The high SNR allows us to acquire a DQD charge-stability diagram in just 20 ms. At such a high data rate, it is possible to acquire charge-stability diagrams in a live “video mode,” enabling real-time tuning of the DQD confinement potential
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Fast Charge Sensing of a Cavity-Coupled Double Quantum Dot Using a Josephson Parametric Amplifier
We demonstrate fast readout of a double quantum dot (DQD) that is coupled to a superconducting resonator. Utilizing a parametric amplifier beyond its range of linear amplification, we improve the signal-to-noise ratio (SNR) by a factor of 2000 compared to the situation with the parametric amplifier turned off. With an integration time of 400 ns comparable to the inverse effective bandwidth, we achieve a SNR of 76. By measuring the SNR as a function of the integration time, we extract an equivalent charge sensitivity of 8 x 10(-5) e/root Hz. The high SNR allows us to acquire a DQD charge-stability diagram in just 20 ms. At such a high data rate, it is possible to acquire charge-stability diagrams in a live “video mode,” enabling real-time tuning of the DQD confinement potential
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On-Chip Quantum-Dot Light Source for Quantum-Device Readout
We use microwave radiation generated by a semiconductor double-quantum-dot (DQD) micromaser for charge-state detection. A cavity is populated with n(c) similar to 6000 photons by driving a current through an emitter DQD. These photons are used to sense the charge state of a target DQD that is located at the opposite end of the cavity. The charge dynamics in the target DQD influences the output power and emission frequency of the maser. Three different readout mechanisms are compared. The detection scheme requires no cavity input field and may potentially be used to improve the scalability of semiconductor and superconducting qubit readout technologies