Structural elucidation of o-linked glycopeptides by high energy collision-induced dissociation

O-linked glycopeptides that bear a GalNAc core with and without the presence of sialic acid have been analyzed by high energy collision-induced dissociation (CID). We show that the CID spectra from the glycosylated precursor ions contain sufficient information to identify the peptide sequence and to determine the glycosylated site(s). Asialo O-linked glycopeptides, previously prepared from a tryptic digest of bovine fetuin were studied. One of the glycopeptides contained only a single Hex (hexose)-HexNAc (N-acetylhexosamine) substitution at Thr262, whereas the other exhibited Hex-HexNAc moieties at both Thr262 and Ser264. In addition, sialo and asialo fetuin glycopeptides from a pronase digest were derivatized with t-butoxycarbonyl-tyrosine, and characterized by high energy CID analysis. The presence of a Galβ(1,3)GalNAc core structure at Ser264 was confirmed by using the substrate specificity of endo-α-N-acetylgalactosaminidase. These studies revealed the presence of a β-galactosidase specific for β(1,4) linkages in the endo-α-N-acetylgalactosaminidase preparation employed. Finally, the relative stability of N-and O-glycosyl bonds to high energy CID is addressed based upon comparison of the behavior of a synthetic N-linked glycopeptide with analogous O-linked structures

Euclidean wormholes with Phantom field and Phantom field accompanied by perfect fluid

We study the classical Euclidean wormhole solutions for the gravitational systems with minimally coupled pure Phantom field and minimally coupled Phantom field accompanied by perfect fluid. It is shown that such solutions do exist and then the general forms of the Phantom field potential are obtained for which there are classical Euclidean wormhole solutions.Comment: 15 pages, major revision with perfect flui

The energy and stability of D-term strings

Cosmic strings derived from string theory, supergravity or any theory of choice should be stable if we hope to observe them. In this paper we consider D-term strings in D=4, N=1 supergravity with a constant Fayet-Iliopoulos term. We show that the positive deficit angle supersymmetric D-term string is non-perturbatively stable by using standard Witten-Nester techniques to prove a positive energy theorem. Particular attention is paid to the negative deficit angle D-term string, which is known to violate the dominant energy condition. Within the class of string solutions we consider, this violation implies that the negative deficit angle D-term string must have a naked pathology and therefore the positive energy theorem we prove does not apply to it. As an interesting aside, we show that the Witten-Nester charge calculates the total gravitational energy of the D-term string without the need for a cut-off, which may not have been expected.Comment: 18 pages. v2: minor changes and references adde

Mersenne Primes, Polygonal Anomalies and String Theory Classification

It is pointed out that the Mersenne primes $M_p=(2^p-1)$ and associated perfect numbers ${\cal M}_p=2^{p-1}M_p$ play a significant role in string theory; this observation may suggest a classification of consistent string theories.Comment: 10 pages LaTe

Kinky D-branes and straight strings of open string tachyon effective theory

In this letter we construct the kink D1-brane super D-helix solution and its T-dual the D2-brane supertube using the effective action of non-BPS tachyonic D-branes . In the limit of zero angular momentum, both types of solutions collapse to zero radius, giving rise respectively to a degenerate string configuration corresponding to a particle travelling with the speed of light and to a static straight string configuration. These solutions share all the properties of fundamental strings and do not have the pathological behavior of other solutions previously found in this context. A short discussion on the ``generalized gauge transformations'' suggested by Sen is used to justify the validity of our approach.Comment: 10 pages, latex, typos corrected and references adde

Supermembranes and Super Matrix Models

We review recent developments in the theory of supermembranes and their relation to matrix models.Comment: Invited lecture presented at the Corfu Workshop, September 20 - 26, 1998, of the TMR Project "Quantum Aspects of Gauge Theories, Supersymmetry and Unification" (ERBFMRXCT96-0045), to appear in the proceedings. Latex 41 p

Trying to Grasp a Sketch of a Brain for Grasping

Ritter H, Haschke R, Steil JJ. Trying to Grasp a Sketch of a Brain for Grasping. In: Sendhoff B, ed. Creating Brain-Like Intelligence. Lecture Notes in Artificial Intelligence; 5436. Berlin, Heidelberg: Springer; 2009: 84-102

Gauge Theory and the Excision of Repulson Singularities

We study brane configurations that give rise to large-N gauge theories with eight supersymmetries and no hypermultiplets. These configurations include a variety of wrapped, fractional, and stretched branes or strings. The corresponding spacetime geometries which we study have a distinct kind of singularity known as a repulson. We find that this singularity is removed by a distinctive mechanism, leaving a smooth geometry with a core having an enhanced gauge symmetry. The spacetime geometry can be related to large-N Seiberg-Witten theory.Comment: 31 pages LaTeX, 2 figures (v3: references added

Nambu-Poisson Bracket and M-Theory Branes Coupled to Antisymmetric Fluxes

By using the recently proposed prescription arXiv:0804.3629 for obtaining the $M5$ brane action from multiple $M2$ branes action in BLG theory, we examine such transition when 11 Dimensional background antisymmetric fluxes couple to the $M2$ brane world volume. Such couplings was suggested in arXiv:0805.3427 where it was used the fact that various fields in BLG theory are valued in a Lie 3-algebra. We argue that this action and promoting it by Nambu-Poisson bracket gives the expected coupling of fluxes with $M5$ brane at least at weak coupling limit. We also study some other aspects of the action for example, the gauge invariance of the theory.Comment: 14 page

Intersection rules, dynamics and symmetries

We consider theories containing gravity, at most one dilaton and form field strengths. We show that the existence of particular BPS solutions of intersecting extremal closed branes select the theories, which upon dimensional reduction to three dimensions possess a simple simply laced Lie group symmetry G. Furthermore these theories can be fully reconstructed from the dynamics of such branes and of their openings. Amongst such theories are the effective actions of the bosonic sector of M-theory and of the bosonic string. The BPS intersecting brane solutions form representations of a subgroup of the group of Weyl reflections and outer automorphisms of the triple Kac-Moody extension G+++ of the G algebra, which cannot be embedded in the overextended Kac-Moody subalgebra G++ characterising the cosmological Kasner solutions.Comment: Latex 30 pages, 3 figure