Impact of Hepatic Steatosis on Disease-Free Survival in Patients with Non-B Non-C Hepatocellular Carcinoma Undergoing Hepatic Resection.

[Background]Although the prevalence of non-B non-C hepatocellular carcinoma (NBNC HCC) has increased, its clinicopathologic characteristics remain unclear. [Methods]We retrospectively analyzed 518 HCC patients who underwent hepatic resection. Hepatitis B surface antigen- and hepatitis C antibody-negative patients were categorized into the NBNC HCC group (n = 145); others were categorized into the hepatitis B or C HCC (BC HCC) group (n = 373). We subdivided the etiologies of NBNC HCC according to alcohol intake and presence of steatosis. [Results]NBNC HCC was associated with nonalcoholic fatty liver disease (NAFLD) (13.1 %), fatty liver disease with moderate alcohol intake (9.0 %), alcoholic liver disease (ALD) (29.7 %), cryptogenic disease (44.1 %), and other known etiologies (4.1 %). The prevalence of obesity, diabetes mellitus, and hypertension was higher and hepatic function was better in the NBNC HCC group, which had significantly larger tumors than the BC HCC group. The entire NBNC HCC group displayed similar overall and disease-free survival as the BC HCC group. Among the subdivisions, NAFLD-associated HCC patients had significantly better disease-free survival than ALD-associated HCC and BC HCC patients. Microvascular invasion (hazard ratio [HR] 2.30; 95 % confidence interval [CI] 1.33–3.96) and steatosis area <5 % of noncancerous region (HR 2.13; 95 % CI 1.21–3.93) were associated with disease-free survival in NBNC HCC patients. [Conclusions]The prognosis of NBNC HCC was similar to that of BC HCC. Among NBNC HCC patients, NAFLD-associated HCC patients had a relatively low recurrence risk. Absence of steatosis in hepatic parenchyma had a significant impact on disease-free survival in NBNC HCC patients

不登校経験のある新入生の精神的健康に関する研究(<特集>スポーツマネジメント)

関西国際大学カウンセリング室では,精神保健問題の早期発見・早期対応を目的として,1999年度から新入生に対する生活意識調査を実施している。本稿は,本学の2006年度の新入生を対象として,生活意識調査内のUPI(大学生精神的健康調査)をもとに,不登校経験のある学生の精神健康状態について分析した。その結果,不登校経験者群は未経験者群と比べて,「人と会うのが嫌」「死にたい」「付き合いが嫌」などの『嫌人・不信』の因子及び「悲観的」「気疲れ」「引け目を感じる」などの『こだわり』の因子において,統計的に有意に高かった。次に,いじめられた経験のある不登校経験者群のUPIにおいて,「やる気のなさ」「悲観的」など,無気力感や自己否定感などを体験しやすく,加えて「死にたくなる」の項目の選択率が高まることが明らかになった。Since 1999, the counseling room has conducted the attitude survey of everyday life on newly-enrolled students in order to discover their mental problems and help them cope with them. In the academic year 2006, we conducted the survey of the mental health condition of students who have experience of refusing to go to school as a neurotic symptom through the UPI (University Personality Inventory) on the newly-enrolled students. Our results suggest that the group of the students who have refused to go to school has a statistically stronger tendency than the order in the factor of avoidance of meeting people and of distrust represented by choosing such items as "I don\u27t like to meet people", "I want to die" or "I don\u27t like to get along with someone", and in the factor of a persistent idea or obsession choosing such items as "I am pessimistic" or "I am mentally fatigued". Our results also indicate that the students who were bullied and were no able to go to school in the past tend to have an apathetic feeling or a feeling of self-denial, choosing such items as "I am pessimistic", or "I am reluctant to do anything". Our study also revealed that the rate of choosing the item of "I want to die, " by this group is statistically higher than the other