5 research outputs found
Secondary amine catalysis in enzyme design: broadening protein template diversity through genetic code expansion
- Author
- Publication venue
- Wiley
- Publication date
- 19/04/2024
- Field of study
Secondary amines, due to their reactivity, can transform protein templates into catalytically active entities, accelerating the development of artificial enzymes. However, existing methods, predominantly reliant on modified ligands or Nâterminal prolines, impose significant limitations on template selection. In this study, genetic code expansion was used to break this boundary, enabling secondary amines to be incorporated into alternative proteins and positions of choice. Pyrrolysine analogues carrying different secondary amines could be incorporated into superfolder green fluorescent protein (sfGFP), multidrugâbinding LmrR and nucleotideâbinding dihydrofolate reductase (DHFR). Notably, the analogue containing a Dâproline moiety demonstrated both proteolytic stability and catalytic activity, conferring LmrR and DHFR with the desired transfer hydrogenation activity. While the LmrR variants were confined to the biomimetic 1âbenzylâ1,4âdihydronicotinamide (BNAH) as the hydride source, the optimal DHFR variant favorably used the proâR hydride from NADPH for stereoselective reactions (e.r. up to 92 : 8), highlighting that a switch of protein template could broaden the nucleophile option for catalysis. Owing to the cofactor compatibility, the DHFRâbased secondary amine catalysis could be integrated into an enzymatic recycling scheme. This established method shows substantial potential in enzyme design, applicable from studies on enzyme evolution to the development of new biocatalysts
Reformas e reformismo: "democracia progressiva" e polĂticas sociais (ou "para uma teoria polĂtica da reforma sanitĂĄria")
- Author
- AIKEN Henry O.
- ALTHUSER Louis
- ALTHUSSER Louis
- BENJAMIN
- BENTHAM Jeremy
- BENTLEY Arthur
- BERLINGUER Giovanni
- BERLINGUER Giovanni
- BOBBIO Norberto
- BOBBIO Norberto
- BUCCI-GLUCKSMAN Cristine
- BUCCI-GLUCKSMAN Cristine
- COHN Gabriel
- COMTE Auguste
- COUTINHO Carlos Nelson
- COUTINHO Carlos Nelson
- DAHL Robert
- DAHL Robert
- DONNANGELO Maria Cecilia F.
- ENGELS Friedrich
- GARYSZEWSKI V.
- GARYSZEWSKI V.
- GRAMSCI Antonio
- GRAMSCI Antonio
- GRAMSCI Antonio
- GRUPPI Luciano
- GRUPPI Luciano
- GRUPPI Luciano
- HABERMAS Juergen
- HEGEL Georg W. F.
- HOBBES Thomas
- HUME David
- INGRAO Pietro
- Jaime A. Oliveira
- JESSOP Bob
- KOTHE FlĂĄvio R.
- LENIN Vladimir I. Ulianov
- LENIN Vladimir I. Ulianov
- LENIN Vladimir I. Ulianov
- LOCKE John
- LUXEMBURG Rosa
- LUXEMBURG Rosa
- MACCICOCHI Maria-Antonieta
- MARX Karl
- MCPHERSON C. B.
- MCPHERSON C. B.
- MICHELLES Robert
- MOSCA Caetano
- MUĂOZ Gabriel
- MĂLLER Wolfang
- NAPOLITANO Giorgio
- NEGT Oscar
- NICHOLLS David
- OFFE Claus
- OFFE Claus
- OFFE Claus
- OLIVEIRA Jaime A.
- OLIVEIRA Jaime A.
- OLIVEIRA Jaime A.
- PARETO Vilfredo
- PARETO Vilfredo.Pareto
- POLANYI Karl
- PORTELLI Hugues
- POULANTZAS Nicos
- POULANTZAS Nicos
- POULANTZS Nicos
- ROUSSEAU Jean-Jacques
- SASSOON Donald
- SCHUMPETER Joseph
- SMITH Adam
- THERBORN Goran
- THERBORN Goran
- TOGLIATTI Palmiro
- TOGLIATTI Palmiro
- VICENT Jean-Marie
- VICENT Jean-Marie
- VICENT Jean-Marie
- WEBER Max
- WRIGHT Milss C.
- Publication venue
- Escola Nacional de SaĂșde PĂșblica, Fundação Oswaldo Cruz
- Publication date
- 01/12/1987
- Field of study
Na introdução deste artigo, o autor parte de uma preocupação com o debate atual em torno do processo de tentativa de inovação polĂtica setorial que vem sendo designado entre nĂłs pela expressĂŁo "Reforma SanitĂĄria". Chama a atenção para os diferentes sentidos em que, a seu ver, esta expressĂŁo tem sido utilizada no Brasil E se dispĂ”e a deter-se, particularmente, em um destes sentidos: o que se aproxima da formulação italiana de mesmo nome (a "Riforma SanitĂĄria"). Esta discussĂŁo o leva, no corpo do artigo propriamente dito, a tratar, centralmente, da relação entre as caracterĂsticas assumidas pela ordenação polĂtica liberal contemporĂąnea e a estratĂ©gia gramsci-togliattiana de transição no socialismo, no que tange ao tema das chamadas "PolĂticas PĂșblicas" e, mais particularmente, das "PolĂticas Sociais". O artigo termina com um esboço inicial de um projeto de investigação comparativa nesta ĂĄrea.<br>In the introduction, the author discusses the current debate on the "Reforma SanitĂĄria"; a proposal to innovate health policy. The author draws attention to the different meanings that can be attributed, in his opinion, to the use of this term in Brazil. He focusses particularly on the meaning closer to that of the Italian proposal of the same name ("Riforma Sanitaria"). The discussion leads the author to question the relationship between the characteristics of the contemporary political liberal organization and the Gramsci-Togliattian strategy of the transition in socialism, within the field of "Public Policies" and more specifically ''Social Policies". The article ends with a preliminary outline a comparative investigation in this field
Notas sobre a solidariedade e o fenĂŽmeno da orfandade na sociedade Akan-Agni MorofoĂ© da Costa Do Marfim (Ăfrica Do Oeste)
- Author
- ABITBOL Eliette
- AcĂĄcio Sidinei Almeida Santos
- AMIM Samir
- AMSELLE Jean-Loup
- ANKRAH Maxime
- BAHA Bi Youzan
- BARNETT P.
- BLIBOLO Auguste Didier
- BĂCHU Natalie
- D'ABY F. J. Amon
- DELCROIX Sylvie
- ERNY Pierre
- ESCHLIMAN Jean-Paul
- FARMER Paul
- FOLQUET L. G.
- GASTELLU Jean-Marc
- GUILLAUME AgnĂšs
- HASSOUN Judith
- HOUPHOUĂT-BOIGNY FĂ©lix
- KANIE Anoma-Kanie
- KOBBEN A. J. F.
- KOEGH P.
- LAPLANTINE François
- LEITE FĂĄbio Rubens da Rocha
- LEITE FĂĄbio Rubens da Rocha
- LEITE FĂĄbio Rubens da Rocha
- LEITE FĂĄbio Rubens da Rocha
- MARIE Alain
- NIANE Djibril Tamsir
- SODRĂ Muniz
- STAVENHAGEN Rodolfo
- THOMAS Louis-Vicent
- TURNER Victor
- VIMARD Patrice
- YENOU H
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Rationale, design, and baseline characteristics in Evaluation of LIXisenatide in Acute Coronary Syndrome, a long-term cardiovascular end point trial of lixisenatide versus placebo
- Author
- Abid Mohamed
- Accini Jose Luis
- Acuña Silvia
- Adawi Faiad
- Adenuga Babafemi
- Adina Pop-Moldovan
- Ageev Fail
- Aguilar David
- Aguilar-Orozco Raul
- Ahmad Zia
- Aimaretti Gianluca
- Aizenberg Diego
- Akahori Hiroshi
- Akhmedzhanov Nadir
- Akinboboye Olakunle
- Akright Laura
- Al Mahmeed Wael
- Alanko Juha
- Alappat Paul
- Alawad Mohamad
- Alfonso Teresa
- Alimard Ramin
- Allen Peter
- Alvarez Carlos
- Alvarisqueta Andres
- Alzohaili Opada
- Ambos Anu
- Amerena John
- Amolina Ildze
- Andjelic Jelic Marina
- Andrade Miguel
- Andrews Robert
- Antorrena Isabel
- Araneda Guillermo
- Arango Juan
- Ariani Mehrdad
- Arnold Susan
- Arora Chander
- Arteaga Juan Manuel
- Assaad Samir
- Atar Shaul
- Avram Rodica Ioana
- Azad Nasrin
- Azzam Samir
- Baccaro Claudia
- Bailey Gordon
- Bain Stephen
- Barbarash Olga
- Barbarich Vladimir
- Barkoudah Ebrahim
- Bartolacci Ines
- Bascil Tutuncu Neslihan
- Basu Ambar
- Bayram Edmundo
- Bednarski Janusz
- Belousov Yury
- Ben Abdallah Nejib
- Benjamin Sabrina
- Bentley-Lewis Rhonda
- Berns Svetlana
- Berra Cesare
- Bertrand Olivier
- Bhargava Rakesh
- Bhatnagar Deepak
- Bickerton Alex
- Bijata-Bronisz Renata
- Block Bradley
- Boberg Gunnar
- Bodi Vicent
- Bokarev Igor
- Bolshakova Olga
- Bordonava Anselmo
- Borzadek Eliza
- Botelho Roberto Vieira
- Botella Marta
- Botero Rodrigo
- Boyarkin Mikhail
- Bragança Nuno
- Brahimi Abdel
- Breisblatt Warren
- Bright Tamis
- Bronnum-Schou Jens
- Browne Duncan
- Bryniarski Leszek
- Bunster Lia
- Burgess Lesley
- Burton Jeffrey
- Bustamante Labarta Miguel
- Busz-Papiez Benita
- Byrd Leroy
- Caccavo Alberto
- Calderon Jorge
- Calella Pedro
- Campeau Jean
- Camsari Ahmet
- Cantero Maria
- Cardosa-Torres Francisco
- Cariou Bertrand
- Carranza-Madrigal Jaime
- Castillo Gilberto
- Castro Eholo
- Castro Maria Guadalupe
- Catargi Bogdan
- Cerqueira Maria Jose
- Chacra Antonio
- Charytan David
- Chaturvedi Nishi
- Chavez Carlos
- Chen Li
- Chiang Chern-En
- Chiou Choyen
- Chiu Yu-Wei
- Chochinov Ronald
- Chopda Manoj
- Chopra Vijay
- Christensen Tom
- Christofides Elena
- Chumakova Galina
- Chumburidze Vakhtang
- Chung Choon Hee
- Chung Wook Jin
- Ciardullo Anna Vittoria
- Cif Adriana
- Claggett Brian
- Cobos Leonardo
- Codutti Renzo
- Coetzee Kathleen
- Cohen Ohad
- Cohen Robert
- Commendatore Victor
- Consoli Agostino
- Contzen Christel
- Cooper John
- CorbalĂĄn RamĂłn
- Cornel Jan Hein
- Coronel Julian
- Correa Flores Roger Martin
- Costamagna Osvaldo
- Creteanu Gabriela
- Cucinotta Domenico
- Cuello Jose
- Cure Carlos
- Czajkowska-Kaczmarek Eugenia
- Danilova Larisa
- Dans Antonio
- Dawood Gamil
- Dawood Saleem
- De La Fuente Javier
- De Souza Jose
- Dekkers Paulus
- Del Prato Stefano
- Delchev Alexy
- Delgado ElĂas
- Delibasi Tuncay
- Delport Eluned
- DeMets David
- Dempsey Michael
- Deshpande Neeta
- Di Marco Sandra
- Diaz Rafael
- Dickstein Kenneth
- Dinccag Nevin
- Dmitry Platonov
- Dong Yugang
- Dos Santos Fabio
- Dragomir Dinu
- Drzewiecka Anna
- Du Jianling
- Duarte JoĂŁo
- Duarte-Vera Yan
- Ducena Kristine
- Ducloux Roxane
- Dulak Elzbieta
- Dumas Richard
- Duran Garcia Santiago
- Dussaillant Gaston
- Dutta R.
- Dwivedi Sudhanshu
- Eagerton Donald
- East Cara
- Ebrahim I.
- Efrati Shai
- Eggers German
- Eki Yutaka
- Elder Charles
- Ellis Graham
- Elorza Jose
- Enciso Fidel
- Escalante Miguel
- Farfan Julio
- Fasching Peter
- Feitosa Gilson
- Ferariu Ioana Emilia
- Fernandez Alberto
- Fernando Ronald
- Filteau Pierre
- Finn Peter
- Fischer Hermann
- Fitilev Sergey
- Florenzano Fernando
- Flynn Aiden
- Fogelfeld Leon
- Forti Adriana
- Foucauld Jean
- Frederiks J.
- French William
- Frohnauer Mary
- Fujii Kenshi
- Gaffney Mary
- Galeana Cielmar
- Galyavich Albert
- Gandhi Pramod
- Gangopadhyay Subroto
- Garcia Duran Ruben
- Garcia Henry
- Garcia Luis
- Garcia-Castillo Armando
- Garcia-Hernandez Pedro
- Garcia-Soria Martin
- Garza Jose
- Gaztambide Sonia
- Gerstein Hertzel C.
- Gibson Martin
- Giorda Carlo
- Giordano Carla
- Glezer Maria
- Glonti Salome
- Godoy Gonzalo
- Gogia Harinder
- Golbert Milton
- Gomez Vilamajo Oscar
- Gomez Claudia
- Gomez Maria Honolina
- Gonzalez Castillo Baldomero
- Gonzalez Elis
- Gonzalez Jose Gerardo
- Gonzalez Ronaldo
- Gorban De Lapertosa Silvia
- Gorska Maria
- Gosmanov Aidar
- Granados Arnoldo
- Granger Christopher
- Greenberg Craig
- Greenway Frank
- Grinfeld Diego
- Guo Xiaohui
- Gupta Jugal Bihari
- Gupta Sandeep Kumar
- Gupta Sunil
- Hadjadj Samy
- Hagenow Andreas
- Halpern Alfredo
- Hamankiewicz Maciej
- Hammond Peter
- Han Ping
- Hanna Edward
- Hanna Fahmy
- Haouala Habib
- Hargrove Joe
- Harris Anthony
- Harris Bill
- Hart Terence
- Hartley L. Howard
- Hata Yoshiki
- Hatterjee Sanjay
- Helda Renate
- Henderson Galen
- Hermans Wrm
- Hermida Sonia
- Hernandez Triana Eric
- Hernandez Hector
- Hernandez-Muñuzuri Jesus
- Herrera Milton
- Herrington David
- Hewitt Mitzie
- Himeno Hideo
- Himpel-Bönninghoff Agnes
- Hirayama Atsushi
- Hiregouder Narendra
- Hissa Miguel
- Howard David
- Hu Taohong
- Huang Tsuei-Yuan
- Huidobro Laura Andrea
- Iancu Adrian-Corneliu
- Ismail Siddique
- Issa Basil
- Istratoaie Octavian
- Ivanica Gabriel
- Ivanov Valentin
- Ivanova Luidmila
- Izuora Kenneth
- Jaap Alan
- Jakovlev Ulle
- Jang Hakchul
- Janik Krzysztof
- Jendle Johan
- Jetty Preetham
- Jha Sujeet
- Jiang Bin
- Jimenez Silvia
- Johnston Peter
- Joseph Franklin
- Joseph Jacob
- Joshi Abhijeet
- Jude Edward
- Jörneskog Gun
- Kaddaha Ghaida Mohamad
- Kaiser Nielsen Peter
- Kakariekiene Vaida
- Kalashnikov Victor
- Kalashnikova Marina
- Kaplan Allen
- Kapoor Anoop
- Karnieli Eddy
- Karpenko Oleksandr
- Karpov Yuri
- Kasper Joseph F.
- Kavaliauskiene Roma
- Ke Yuannan
- Kelbe Dudley
- Kelehan Shaun
- Kelly Chris
- Kelly Richard
- Kereiakes Dean
- Kerlan Veronique
- Khaira Ajit
- Khaisheva Larisa
- Khalimov Yuri
- Khan Atir
- Khan Misal
- Khan Noor
- Khan Salman
- Kihm Lars
- Killat Holger
- Kim Chong-Jin
- Kim Jaetaek
- Kim Kyehun
- Kim Ung
- Kincel Krzysztof
- Kishimoto Ichiro
- Klainman Eliezer
- Kleinertz Klaus
- Klyuchkova Neli
- Kobalava Zhanna
- Kobayashi Youichi
- Kocic Radivoj
- Komnenovic Snezana
- Konieczny Marek
- Konrade Ilze
- Korban Elie
- Korpachev Vadym
- Korsoff Pirkko
- Kosch Christine
- Kosiborod Mikhail
- Koski Anna-Mari
- Kosmachova Elena
- Kostenko Victor
- Koval Olena
- Koziolova Natalya
- Kreutzmann Kristin
- Kulibaba Elena
- Kultursay Hakan
- Kumbla Mukund
- Kyoleyan Michael
- KĂžber Lars V.
- Lagrutta Mariana
- Laguerre Jacques
- Lahsen Rodolfo
- Lahtela Jorma
- Lalic Katarina
- Lalic Nebojsa
- Lanas Fernando
- LappegÄrd Knut Tore
- Lappo Mariola
- Lara Susano
- Larenas Gladys
- Larocque James
- Latif Kashif
- Lawson Francesca
- Lee Nae Hee
- Leon De La Fuente Ricardo
- Lesnov Victor
- Lester Frank
- Levin Philip
- Levine Steven
- Levterov Georgi
- Lewis Eldrin F.
- Li Charles
- Li Zhanquan
- Libov Igor
- Licheri Alberto
- Lichiardopol Radu
- Lieberman Phil
- Lisboa Hugo
- Llamas Guillermo
- Lok Dirk
- Lominadze Zaza
- Lonso Elena
- Lopez Rosas Enrique
- Lopez Gabriel Arturo
- Lopez Monica
- Lopez Patricio
- Lovell Charles
- Lu Chieh-Hsiang
- Lu Juming
- Lu Libia
- Lubi Maire
- Lubinski Andrzej
- Lucheva Mariya
- Luciardi Hector
- Lujan Jesus
- Lupovitch Steven
- Luque Edith
- Lyamina Nadezhda
- Ma Changsheng
- Mackinnon Ignacio
- Madu Ivy-Joan
- Maffei Laura
- Magdum Mohan
- Maggioni Aldo P.
- Mahabadi Vahid
- Mahmood Asif
- Malecot Jean-Marc
- Malik Rayaz
- Mannucci Edoardo
- Manrique Helard
- Manriquez Leopoldo
- Manzur Fernando
- Maragos Stavros
- Marck Cornelia
- Mariash Cary
- Marin Francisco
- Marino Javier
- Markov Valentin
- Marmol Alvear Ricardo
- Martin Paul
- Martin Victoria
- Maslyanko Vitaliy
- Mathew James
- Mathew John
- Mathiesen Ulrik
- Mathieu Chantal
- Mauricio Didac
- May Michael
- Mayfield Ronald
- McCall Anthony
- Mcdaniel Clayton
- Mcgrew Frank
- Mckenzie Marcus
- McMurray John J. V.
- Medina Marcelo
- Meeder Joan
- Mefford Ivan
- Mehta Arvind
- Mertes Bernardo
- Micic Dragan
- Mikdadi Ghiath
- Mikhail Magdy
- Militaru Constantin
- Minescu Bogdan
- Minuchin Oscar
- Mitkovskaya Natalya
- Miyaoka Hiroaki
- Moccetti Tiziano
- Mogrovejo Walter
- Moiseev Valentin
- Molchanova Olga
- Molina Dora
- Monchamp Travis
- Montaña Oscar
- Monteiro Pedro
- Montenegro Pablo
- Moore Charles
- Moraes Joao
- Moran Michael
- Morrar Nidal
- Mosenzon Ofri
- Mosley Jonathan
- Mukhopadhyay Babu
- Mulford Mim
- Munoz Ricardo
- Murray John
- Murthy Keshava
- MĂ€rtsin Kaja
- Naidoo Visvakuren
- Nakhle Samer
- Nallasivan Mani
- NedrebĂž BjĂžrn Gunnar
- Nelimarkka Lassi
- Nery Max
- Nielsen Henrik
- Nierop Peter
- Nieto Ortega Ruben
- Niiya Tetsuji
- Nishi Yutaro
- Novaretto Leonardo
- Nozaki Akira
- Ntsekhe Mpiko
- Nunohiro Tatsuya
- O'Kane M.
- O'Reilly Eileen
- Odio Alberto
- Odutayo Kayode
- Oh Charles
- Olelewe Sarah
- Oleynikov Valentin
- Olszanecka-Glinianowicz Magdalena
- Onaca Adriana
- Orio Silvia
- Orlandini Andres
- Orlikova Olga
- Orsi Emanuela
- Otasevic Petar
- Oto Ali
- Oviedo Alejandra
- Palchick Bryce
- Paliwal Yogesh
- Palma Juan Carlos
- Panelo Araceli
- Panov Alexey
- Papademetriou Vasilios
- Parikh Naresh
- Pariona-Javier Marcos
- Park Kyong Soo
- Patel Keyur
- Patel Sudhirkumar
- Patocchi Cristian
- Paul Vincent
- Pei Dee
- Peng Yongde
- Perepelytsya Mykhaylo
- Perez Luis
- Pertseva Tetyana
- Pesic Milica
- Petit Catherine
- Petrie John
- Petrosyan Olena
- Petrulioniene Zaneta
- Peñaherrera-Patiño Carlos
- Pfeffer Marc A.
- Phillips Lawrence
- Piatti Piermarco
- Pieber Thomas
- Piechatzek Richard
- Ping Lin
- Pintilei Ella
- Pinto Miguel
- Pirags Valdis
- Pitts Thomas
- Podoleanu Cristian
- Ponikowski Piotr
- Pontiroli Antonio
- Ponzani Paola
- Pop Lavinia
- Popa Bogdan
- Potthoff Sergio
- Pouleur Anne-Catherine
- Pozzilli Paolo
- Prabhu Mukhya
- Prieto Francisco
- Probstfield Jeffrey L.
- Prohaska Martin
- Pulka Grazyna
- Puttnam Rachel
- PĂ©rez Manghi Federico
- Quadros Alexandre
- Quyyumi Arshed
- Raccah Denis
- Raduan Roberto
- Raev Dimitar
- Rafalskiy Vladimir
- Raffo Carlos
- Rajesh Vinutha
- Ramos Hugo
- Ramos null
- Randhawa Preet
- Ranetti Aurelian Emil
- Rasmussen Soeren
- Rayman Gerry
- Reis Gilmar
- Rekosz Jerzy
- Rendell Marc
- Rey Nannette
- Reyes Eduardo
- Reyes Eliana
- Rha Seungwoon
- Rhie Francis
- Ribeiro Filho Fernando
- Riddle Matthew C.
- Rim Sejoong
- Rinke Andrea
- Rivellese Angela
- Roberts James
- Robinson Anthony
- Robinson Jerome
- Robinson Michael
- Rodier Michel
- Rodionova Tatiana
- Rodrigues Elisabete
- Rodriguez Edgar
- Rodriguez Ignacio
- Rodriguez Jaime
- Rolandi Florencia
- Roldan Yudy
- Rollin Guilherme
- Rooney Desmond
- Rosenthal Svea
- Rossi Paulo
- Rosu Doina
- Rouleau Jean
- Rubino John
- Rudenko Leonid
- Rungby JĂžrgen
- Ryan Eugene
- RĂžnne Henning
- Saa Zarandon Raquel
- Saathoff Steven
- Saavedra Silvia Salome
- Saavedra Victor
- Sachmechi Isaac
- Sahay Rakesh
- Sahin Mahmut
- Saifi Ali
- Sainsbury Chris
- Saito Tomiyoshi
- Sakalyte Gintare
- Salacata Abraham
- Samitin Vasily
- Sanchez Vallejo Gregorio
- Sanders Robyn
- Sangla Kunwarjit
- Sanhueza Patricio
- Sanson Jodi
- Santos Elizabete
- Saravanan Ponnusamy
- Satoh Yasuhiro
- Savin Virginia
- Saygili Fusun
- Scarpa Aldo
- Schabauer Alex
- Schattner Mark
- Schellenberg Detlev
- Schiavi Lilia
- Schmedtje John
- Schokotov Vladimir
- Schwartz Alan
- Schygiel Pablo
- Scott Cranford
- Sebastian Peter John
- Seferovic Petar
- Selagamsetty Munni
- Sepulveda Pablo
- Sethuraman Selvamani
- Sgarbi Jose
- Shah Navneet
- Shakher Jayadave
- Shamanna Paramesh
- Shannon Michael
- Shaw Sylvia
- Shelbaya Salah
- Shi Yongquan
- Shilkina Nataliya
- Shin Sung-Hee
- Shogenov Zaur
- Shumkova Rositsa
- Shustov Sergey
- Shvarts Yuri
- Shyu Kou-Gi
- Siebert Mirna
- Sime Iveta
- Singal Dinesh
- Singh Baldev
- Singh K. Singh
- Singh Paminder
- Sjoberg Robert
- Skagen Knud
- Skudlarski Dariusz
- Slimane Hedia
- Smith Kenneth
- Sobolev Konstantin
- Sofley Carl
- Sokolova Jelena
- Solis Carmen Lia
- Solomon Scott D.
- Somasekharan Arun
- Sonn Anthony
- Sorof Suzanne
- Soroka Eugene
- Soto Alfonso
- Soto Nestor
- Souza Juliana
- Souza Maria Regina
- Spellman C. W.
- Sreenivasamurthy Lakshminarayanappa
- Stankovic Goran
- Steinhoff Jeffrey
- Stern Naftali
- Stobschinski De Alba Carlos Alejandro
- Stryuk Raisa
- Su Guohai
- Sudzhaeva Svetlana
- Sulit Dennis Jose
- Supe Pravin
- Suplotova Ludmila
- Suresh Damodhar
- Svensson Karl-Axel
- Sy Rosa Allyn
- Syan Gurcharan
- Syan Rajinder
- Sychov Oleg
- Synenko Volodymyr
- Szymkowiak Katarzyna
- Tahir Mohammad
- Takahashi Akihiko
- Takahashi Junichiro
- Takase Hiroyuki
- Takase Shinichi
- Tanenberg Robert
- Tang Baopeng
- Tardif Jean-Claude
- Tase Adrian
- Tesloianu Dan Nicolae
- Thawani Hemant
- Thomsen Kristian Korsgaard
- Thomson Stephen
- Thrasher James
- Timonera Miriam
- Todua Fridon
- Tokmakova Mariya
- Torp-Pedersen Christian
- Torres Claudia
- Torstensson Ingemar
- Toursarkissian Nicole
- Trachtenbarg David
- Trivi Marcelo
- Trotta Michael
- Tseluyko Vira
- Tsoukas George
- Tsuboko Yusuke
- Tsujimoto Mitsuru
- Tsujino Motoyoshi
- Tsuzuki Masahiro
- Tuan Weiming
- Tuomilehto Jaakko
- Turcios Erick
- Turgeman Yoav
- Turner Jeremy
- Twahirwa Marcel
- Tzekova Maria
- Ueng Kwo-Chang
- Ulla Maria
- Umpierrez Guillermo
- Urboniene Audrone
- Urdiales Pedro
- Uribe Marittza
- Vaid Brij
- Vallejos Julio
- Van Gaal William
- Van Zyl Louis
- Vance Carl
- Vasko Peter
- Vazir Ali
- Vazquez-Garcia Abraham
- Velasco-Sanchez Raul
- Venter Tjaart
- Vico Marisa
- Vida Manuel
- Vides Hella
- Vidrio Maricela
- Viktorova Inna
- Villalobos Renato
- Vinereanu Dragos
- Vinhas Margarida
- Vishnevsky Alexander
- Vorokhobina Natalia
- Wainstein Julio
- Waisman Florencia
- Wang Thomas
- Wang Tzung-Dau
- Warner Alberta
- Warnica James Wayne
- Watanabe Shuichi
- Watson Henry
- Weber Sandra
- Webster Brian
- Weindorff Kathleen
- Weinrauch Larry
- Welch Michelle
- Welker James
- Westerberg Bernhard
- White Anthony
- White Lindsey
- Whitelaw Donald
- Wilczewski Przemyslaw
- Wilding John
- Wiles Philip
- Williams Marcus
- Wu Wen-Chih
- Wu Yujun
- Wynne Alan
- Wyss Fernando
- Xu Biao
- Yakusevich Vladimir
- Yakushin Sergey
- Yamada Takahisa
- Yang Jiefu
- Yang Jinkui
- Yang Yanmin
- Yañez Mario
- Yeap Bu
- Yigit Zerrin
- Yocono Mark
- Yordanov Viktor
- Yuen Kevin
- Yupanqui Hernan
- Zadionchenko Vladimir
- Zalevskaya Alsu
- Zalevsky Grigory
- Zarankiene Rima
- Zateyshchikova Anna
- Zavala Alejandro
- Zhuravleva Larisa
- Zidi Borni
- Zorkun Cafer
- Zubiate Carlos
- Zuraw Bruce L.
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2015
- Field of study
BACKGROUND:
Cardiovascular (CV) disease is the leading cause of morbidity and mortality in patients with type 2 diabetes mellitus (T2DM). Furthermore, patients with T2DM and acute coronary syndrome (ACS) have a particularly high risk of CV events. The glucagon-like peptide 1 receptor agonist, lixisenatide, improves glycemia, but its effects on CV events have not been thoroughly evaluated.
METHODS:
ELIXA (www.clinicaltrials.gov no. NCT01147250) is a randomized, double-blind, placebo-controlled, parallel-group, multicenter study of lixisenatide in patients with T2DM and a recent ACS event. The primary aim is to evaluate the effects of lixisenatide on CV morbidity and mortality in a population at high CV risk. The primary efficacy end point is a composite of time to CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for unstable angina. Data are systematically collected for safety outcomes, including hypoglycemia, pancreatitis, and malignancy.
RESULTS:
Enrollment began in July 2010 and ended in August 2013; 6,068 patients from 49 countries were randomized. Of these, 69% are men and 75% are white; at baseline, the mean ± SD age was 60.3 ± 9.7 years, body mass index was 30.2 ± 5.7 kg/m(2), and duration of T2DM was 9.3 ± 8.2 years. The qualifying ACS was a myocardial infarction in 83% and unstable angina in 17%. The study will continue until the positive adjudication of the protocol-specified number of primary CV events.
CONCLUSION:
ELIXA will be the first trial to report the safety and efficacy of a glucagon-like peptide 1 receptor agonist in people with T2DM and high CV event risk
Evaluation of a quality improvement intervention to reduce anastomotic leak following right colectomy (EAGLE): pragmatic, batched stepped-wedge, cluster-randomized trial in 64 countries
- Author
- Aarts Frits
- Ababneh Hazim
- Abad-Motos Ane
- Abaidalla Ahmed
- Abbakar Malaz
- Abd El Aal Ahmed
- Abd-Errazik Mohammad Ahmad
- Abdalradiy Abdalrahmman G
- Abdelkhalek Mohamed
- Abdelkhalek Mostafa
- Abdellatif Ahmed
- Abdellatif Mohamed
- Abdelsaid Kirolas
- Abdou Khaled
- Abdulfatah Mustapha
- Abdullah Mohammad Amer
- Abdullahi Mustapha Miko Mohammed
- AbellĂĄn Antonio Melero
- Abeysinghe Nayana
- Abiyere Henry
- Achimas-Cadariu Patriciu Andrei
- Adakaya Sıla
- Adam Nicolas
- Adams Benita
- Adams Ferdinand
- Adegboye Kazeem
- Adeyeye Ademola
- Adra Lama
- Adu-Poku Patricia
- Afuwape Oludolapo
- Afzal Ameer
- Afzal Muhammad Farooq
- Agapov Mihail
- Agara Daniel
- Aggarwal Manisha
- Agger Erika
- Aghadi Ifeanyi Kene
- Ahmed Amjed Yassir
- Ahmed Haleemasahdia
- Ahmed Khalil
- Ahmed Manar
- Ahmed Masood
- Ahmed Safia
- Ahn Hong Min
- Aibe Raquel
- Aigner Felix
- Aissat Abdenour
- Aitbaeva Arai
- Akay Omer
- Akbar Ali
- Akbas Ahmet
- Akere Abidemi
- Akesen Selcan
- Akgun Erhan
- Akhtar Naseem
- Akın Emrah
- Akova Elif
- Aktas Serhat
- Akçay Ăzlem
- Al Masri Mahmoud
- Al-Alnsi Ahmed
- Al-Hutheifi Roqia'A
- Al-Jarrah Amar
- Al-Naggar Hamza
- Al-Shehari Mohammed
- Alamin Nadeen
- Alawi Raneen
- Alawlaqi Dina
- Alawneh Fade
- Alberola Maria José
- Albers Michael
- Alcolea Natalia GonzĂĄlez
- Aleem Muhammad
- Alegre InĂȘs
- Alegre Javier Martinez
- Alexandre Flavia
- Alexandrescu Corina
- Alexnder Abelevich
- Alexopoulou Kalliopi
- Alfonso Beatriz AmorĂłs
- Ali Ahmed
- Ali Che Saniati Che
- Ali Danish
- Ali Madeeha
- Ali Mahmoud Abdelwahab
- Ali Manhal Hashim
- Ali Noura Al
- Alikhanli Jhale
- Aliyeva Zumrud
- Aliyu Mohammed
- Aljawder Hasan
- Allen Kate
- Almahmeed Ebrahim
- Alonso Alfredo
- Alonso Javier Etreros
- Alsamneh Muneer
- Alsayadi Ramzi
- Altinel Yuksel
- Altintoprak Fatih
- Altomare Donato F
- Alvarenga Isabella
- Alvarez Laura Jimenez
- Alvarez-Bautista Francisco Emmanuel
- Alvarez-DĂez Marcos
- Alves Brenda Chayanny
- Amadigwe Rita
- Amado Andreia
- Amado FabĂola
- Amador Cristina GarcĂa
- Amanullah Nazli
- Amaral HĂ©lida Aline Tomacheski
- Amaral Luis
- Amin-Tai Hizami
- Aminu Bashiru
- Amir Ahmad Suhaimi
- Ammar Ahmed Siddique
- Ammar Mona Ahmed
- Ammendola Michele
- Ammerata Giorgio
- Amorim Edgar
- Ancans Guntis
- Anderson Tom
- Andrade Diogo
- Andrejevic Predrag
- AndrĂ©s Beatriz DĂaz San
- Anestiadou Elissavet
- Ang Chin Wee
- Angelo Franceschi
- Anokhin Evgeny
- Anoldo Pietro
- Antakia Ramez
- Anton Majd
- Antonelli Serena
- Antropoli Carmine
- Anula Rocio
- Anwar Jamal
- Anyadike Florence
- Apostolakidou Magda
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- Aprea Giovanni
- Arabadzhiev Angel
- Arakawa Satoshi
- Arauz Jazmin
- Aravindan U
- Aremu Abdurrahman
- Aremu Isiaka
- Argawy Osama
- Arican Can
- Arida Zahed Abu
- Armellin Claudia
- Arnaoutoglou Eleni
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- Arya Shobhit
- Arynov Ardak
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- Asano Yukio
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- Asgarov Mohsum
- Ashmawy Soad
- Aslam Muhammad Imran
- Assimakopoulou Elena
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- Azevedo Patricia
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- Ballian Nikiforos
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- Baloyiannis Ioannis
- Bamford Richard
- Bandar Mahdi Al
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- Baptista Victor
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- Barbalace Nicolas
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- Barrena-Blazquez Silvestra
- Barton Jess
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- Basnyat Pradeep
- Batool Sana
- Bautista Wilson Manuel SĂĄnchez
- Bayhan ZĂŒlfĂŒ
- Bayo José Manuel Muros
- BayĂłn Raquel Ălvaro
- Baños Pedro Antonio Parra
- Beard David
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- Belarmino Armin
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- Bellato Vittoria
- BeltrĂĄn de Heredia Juan
- Belvedere Angela
- Benetti Emilio
- Benetti Sara
- Bengueddach Aicha
- Benjelloun El Bachir
- Benkabbou Amine
- Bennett James
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- Bergamini Carlo
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- Bethune Robert
- Bezede Cosmin
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- Bhangu Aneel
- Bhargava Aman
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- Bianco Francesco
- Bigoni Irene
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- Blackwell Sue
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- Bomfa-Barbosa Alysson
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- Bordom Daniel Osei
- Borges Filipe
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- Bose Bodhisattva
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- Boudjenan-Serradj Nabil
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- Brandström Gustav
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- Caliendo Domenico
- Calin Camelia
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- Campbell Marion
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- Carlin Patricia Saez
- Carlini Massimo
- Carlos Sandra
- Carneros Virginia Jimenez
- Carosso Fabio
- Caroço Teresa Vieira
- Carpelan Anu
- Carpenter Holly
- Carrascosa-Morales Irene
- Carrie Augusto
- Carrizo Claudia
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- Carvello Michele
- Casanova Daniel
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- Castaldi Antonio
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- Castiglioni Simone
- Castillo Enrique Roca
- Castro Marta Cuartero
- Catalano Pablo
- Cato Liam
- Caz Esra
- Cebolla Elena Sagarra
- Cecchini Ilaria
- CeldrĂĄn Rebeca GonzĂĄlez
- Celik Hale Kefeli
- Ceretti Andrea Pisani
- Ceron Silvia Ferrer
- Cervellera Maurizio
- Cervone Carmela
- Chacko Anil
- Chandrasinghe Pramodh
- Charakopoulou Alexandra
- Chardalias Leonidas
- Chaturvedi Arun
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- Chaudhari Abhishek
- Chaudhry Sanjay
- Chawla Tabish
- Chee Corissa
- Chen Nevin
- Cheng Kuang I
- Chiarugi Massimo
- Chisthi Meer
- Chitnis Abhishek
- Chitul Andrei
- Chmielewski Gaspard
- Cholewa Hanna
- Chornet Marta RosellĂł
- Chowdhary Manish
- Chowdhury Sharfuddin
- Chowdhury Sharfuddin M
- Chowdri Nisar
- Christensen Peter
- Christodoulidis Grigorios
- Chrysos Emmanuel
- Chua Lorna
- Chubukova Natlia
- Chung Jun Seong
- Church Robert
- Chwat Carina
- Ciabattari Paula
- Cianchi Fabio
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- Ciftci Ahmet Burak
- Cigagna Luca
- Cini Charles
- Ciotarla Danut Constantin
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- Conceição Luis
- Conde Juan Guillermo Ais
- Connolly Lewis
- Conversano Ivana
- Convertini Ornella
- Cook Esther
- Cooke Fiachra
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- Coratti Francesco
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- Crabtree Nicholas
- Creavin Ben
- Cremonini Camilla
- Crescentini Giacomo
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- Cristian Daniel
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- Cullinane Carolyn
- Cuneo Davide
- Cunha Miguel
- Curbelo Jacqueline
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- CurrĂ Maria Cristina
- CurrĂĄs Rosana PĂ©rez
- CustĂłdio Pedro
- CutellĂš Clelia
- Czarnecki Roman
- D'Angelo Salvatore
- D'Ugo Stefano
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- da Silveira Sete Alexandre
- Dainius Edvinas
- Dalton Richard
- Damieta Marta Pascual
- Danassi Despoina
- Danelli Piergiorgio
- Danial Aghyad Kudra
- Daniels Ian R
- Daniyan Muhammad
- Danna Riccardo
- Danys Donatas
- Dardanov Dragomir
- Daryanani Deepu
- Dassanayake Vihara
- DaugÄla Edvardas
- Dauri Mario
- Davidovskaja Larisa
- Davies Emma
- Davis Cian
- Dawson Brett E
- Dawson Carmel
- de Andrés-Asenjo Beatriz
- de Deken Julie
- de Franciscis Silvia
- de Kort Chantal
- de La Plaza Llamas Roberto
- de Lacy Antonio Maria
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- de LeĂłn RendĂłn Jorge Luis
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- Eng Stanley Chee Ren
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- Gutierrez Victor Manuel Maciel
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- Gökay Banu Vural
- GĂŒler Sertaç Ata
- GĂŒlmez Mehmet
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- Korkolis Dimitrios
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- Mba Emmanuel Louis
- Mcdermott Frank D
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- Peker YaĆar Subutay
- Pelipas Yuriy
- Pellicer-Franco Enrique M
- Pellino Gianluca
- Peltrini Roberto
- Peneva Kristin
- Pengerma Pasi
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- Zaycev Andrey
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- Zeringa Georgia
- Zimmerman David D E
- Zuhdy Mohammad
- Zvirych Vitalii
- Zywicka Ewa
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- Ăngelo Miguel Duarte
- ĂSullivan Sara Nuñez
- Ăzçelik Mehmet Faik
- Äoza Ivo
- Ćanlı Ahmet Necati
- Publication venue
- Publication date
- 01/01/2023
- Field of study
Background
Anastomotic leak affects 8 per cent of patients after right colectomy with a 10-fold increased risk of postoperative death. The EAGLE study aimed to develop and test whether an international, standardized quality improvement intervention could reduce anastomotic leaks.
Methods
The internationally intended protocol, iteratively co-developed by a multistage Delphi process, comprised an online educational module introducing risk stratification, an intraoperative checklist, and harmonized surgical techniques. Clusters (hospital teams) were randomized to one of three arms with varied sequences of intervention/data collection by a derived stepped-wedge batch design (at least 18 hospital teams per batch). Patients were blinded to the study allocation. Low- and middle-income country enrolment was encouraged. The primary outcome (assessed by intention to treat) was anastomotic leak rate, and subgroup analyses by module completion (at least 80 per cent of surgeons, high engagement; less than 50 per cent, low engagement) were preplanned.
Results
A total 355 hospital teams registered, with 332 from 64 countries (39.2 per cent low and middle income) included in the final analysis. The online modules were completed by half of the surgeons (2143 of 4411). The primary analysis included 3039 of the 3268 patients recruited (206 patients had no anastomosis and 23 were lost to follow-up), with anastomotic leaks arising before and after the intervention in 10.1 and 9.6 per cent respectively (adjusted OR 0.87, 95 per cent c.i. 0.59 to 1.30; P = 0.498). The proportion of surgeons completing the educational modules was an influence: the leak rate decreased from 12.2 per cent (61 of 500) before intervention to 5.1 per cent (24 of 473) after intervention in high-engagement centres (adjusted OR 0.36, 0.20 to 0.64; P < 0.001), but this was not observed in low-engagement hospitals (8.3 per cent (59 of 714) and 13.8 per cent (61 of 443) respectively; adjusted OR 2.09, 1.31 to 3.31).
Conclusion
Completion of globally available digital training by engaged teams can alter anastomotic leak rates. Registration number: NCT04270721 (http://www.clinicaltrials.gov)