A novel real-time detailed feedback collection and interaction tool for large classes

CONTEXT The existing approaches towards interactive student feedback and question collection have two major drawbacks. First, instructors are only provided with generic feedback, typically at the end of a teaching period. Second, students are not provided with opportunity to give content-specific feedback or raise questions on specific sections of content during the lecture. The latter is especially important in large classes with students from non-English speaking background who are generally less likely to actively participate in discussions. PURPOSE This paper aims to develop and test a user-friendly and automated platform, with efficient data management structure, which facilitates real-time collection and addressing of students’ feedback on a specific part of topics discussed during the class. APPROACH A web-based software has been developed using annotation technologies which assists students in providing anonymous and content-specific comments on lecture materials. The software equips lecturers with a real-time platform for retrieval of comments classified based on their area, type and frequency. The platform contains features that enable users, teachers, for analytical assessment of both teaching and learning performance. RESULTS The trial use of the designed platform has primarily increased engagement of students in the class discussions. This trend is specifically observed amongst international students who have gained confidence to raise more questions, compared to the traditional teaching methods. Concurrently, the lecturer has dramatically decreased his response period to students’ queries to nearly real-time through receiving classified comments adhered to a particular part of the lecture. CONCLUSIONS The software allows for structured analysis of course materials and students’ feedback which can be further used to update teaching standards. Moreover, it improves teacher-student relationships through timely and purposeful addressing of instructional issues

Brain immune cells undergo cGAS-STING-dependent apoptosis during herpes simplex virus type 1 infection

Protection of the brain from viral infections involves the type I interferon (IFN-I) system, defects in which renders humans susceptible to herpes simplex encephalitis (HSE). However, excessive cerebral IFN-I levels leads to pathologies, suggesting the need for tight regulation of responses. Based on data from mouse models, human HSE cases, and primary cell culture systems, we here show that microglia and other immune cells undergo apoptosis in the HSV-1-infected brain through a mechanism dependent on the cyclic GMP-AMP synthase (cGAS) - stimulator of interferon genes (STING) pathway, but independent of IFN-I. HSV-1 infection of microglia induced cGAS-dependent apoptosis at high viral doses, while lower viral doses led to IFN-I responses. Importantly, inhibition of caspase activity prevented microglial cell death and augmented IFN-I responses. Accordingly, HSV-1-infected organotypic brain slices, or mice treated with caspase inhibitor, exhibited lower viral load and improved outcome of infection. Collectively, we identify an activation-induced apoptosis program in brain immune cells which down-modulates local immune responses

Health-related quality of life in infertile couples receiving IVF or ICSI treatment

<p>Abstract</p> <p>Background</p> <p>Infertile couples might experience psychological distress and suffer from impaired health-related quality of life. This study aimed to examine health-related quality of life in infertile couples receiving either in-vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) treatment.</p> <p>Methods</p> <p>This was a cross-sectional study of quality of life in infertile couples attending to Vali-e-Asr Reproductive Health Research Center or Royan Institute for either IVF or ICSI treatment in Tehran, Iran. Health-related quality of life was assessed using the Short Form Health Survey (SF-36). Patients' demographic and clinical characteristics were also recorded. Data were analyzed to compare quality of life in infertile women and men and to indicate what variables predict quality of life in infertile couples.</p> <p>Results</p> <p>In all 514 women and 514 men (n = 1028) were studied. There were significant differences between women and men indicating that male patients had a better health-related quality of life. Also health-related quality of life was found to be better in infertility due to male factor. Performing logistic regression analysis it was found that female gender, and lower educational level were significant predictors of poorer physical health-related quality of life. For mental health-related quality of life in addition to female gender and lower educational level, younger age also was found to be a significant predictor of poorer condition. No significant results were observed for infertility duration or causes of infertility either for physical or mental health-related quality of life.</p> <p>Conclusion</p> <p>The findings suggest that infertility duration or causes of infertility do not have significant effects on health-related quality of life in infertile couples. However, infertile couples, especially less educated younger women, are at risk of a sub-optimal health-related quality of life and they should be provided help and support in order to improve their health-related quality of life.</p

Finite element simulation of nonlinear convective heat and mass transfer in a micropolar fluid-filled enclosure with Rayleigh number effects

A mathematical model is presented to study the double-diffusive convective heat and mass transfer of a micropolar biofluid in a rectangular enclosure, as a model of transport phenomena in a bioreactor. The vertical walls of the enclosure are maintained at constant but different temperatures and concentrations. The conservation equations for linear momentum, angular momentum, energy and species concentration are formulated subject to appropriate boundary conditions and solved using both finite element and finite difference numerical techniques. Results are shown to be in excellent agreement between these methods. Several special cases of the flow regime are discussed. The distributions for streamline, isotemperature, isoconcentration and (isomicrorotation) are presented graphically for different Lewis number, buoyancy parameter, micropolar vortex viscosity parameter, gyration viscosity parameter, Rayleigh number, Prandtl number and micro-inertia parameter. Micropolar material parameters are shown to considerably influence the flow regime. The flow model has important applications in hybrid aerobic bioreactor systems exploiting rheological suspensions e.g. fermentation

Prevalence, years lived with disability, and trends in anaemia burden by severity and cause, 1990-2021: findings from the Global Burden of Disease Study 2021

Background Anaemia is a major health problem worldwide. Global estimates of anaemia burden are crucial for developing appropriate interventions to meet current international targets for disease mitigation. We describe the prevalence, years lived with disability, and trends of anaemia and its underlying causes in 204 countries and territories. Methods We estimated population-level distributions of haemoglobin concentration by age and sex for each location from 1990 to 2021. We then calculated anaemia burden by severity and associated years lived with disability (YLDs). With data on prevalence of the causes of anaemia and associated cause-specific shifts in haemoglobin concentrations, we modelled the proportion of anaemia attributed to 37 underlying causes for all locations, years, and demographics in the Global Burden of Disease Study 2021. Findings In 2021, the global prevalence of anaemia across all ages was 24·3% (95% uncertainty interval [UI] 23·9–24·7), corresponding to 1·92 billion (1·89–1·95) prevalent cases, compared with a prevalence of 28·2% (27·8–28·5) and 1·50 billion (1·48–1·52) prevalent cases in 1990. Large variations were observed in anaemia burden by age, sex, and geography, with children younger than 5 years, women, and countries in sub-Saharan Africa and south Asia being particularly affected. Anaemia caused 52·0 million (35·1–75·1) YLDs in 2021, and the YLD rate due to anaemia declined with increasing Socio-demographic Index. The most common causes of anaemia YLDs in 2021 were dietary iron deficiency (cause-specific anaemia YLD rate per 100 000 population: 422·4 [95% UI 286·1–612·9]), haemoglobinopathies and haemolytic anaemias (89·0 [58·2–123·7]), and other neglected tropical diseases (36·3 [24·4–52·8]), collectively accounting for 84·7% (84·1–85·2) of anaemia YLDs. Interpretation Anaemia remains a substantial global health challenge, with persistent disparities according to age, sex, and geography. Estimates of cause-specific anaemia burden can be used to design locally relevant health interventions aimed at improving anaemia management and prevention. Funding Bill & Melinda Gates Foundation

Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults

Background Underweight and obesity are associated with adverse health outcomes throughout the life course. We estimated the individual and combined prevalence of underweight or thinness and obesity, and their changes, from 1990 to 2022 for adults and school-aged children and adolescents in 200 countries and territories. Methods We used data from 3663 population-based studies with 222 million participants that measured height and weight in representative samples of the general population. We used a Bayesian hierarchical model to estimate trends in the prevalence of different BMI categories, separately for adults (age ≥20 years) and school-aged children and adolescents (age 5–19 years), from 1990 to 2022 for 200 countries and territories. For adults, we report the individual and combined prevalence of underweight (BMI 2 SD above the median). Findings From 1990 to 2022, the combined prevalence of underweight and obesity in adults decreased in 11 countries (6%) for women and 17 (9%) for men with a posterior probability of at least 0·80 that the observed changes were true decreases. The combined prevalence increased in 162 countries (81%) for women and 140 countries (70%) for men with a posterior probability of at least 0·80. In 2022, the combined prevalence of underweight and obesity was highest in island nations in the Caribbean and Polynesia and Micronesia, and countries in the Middle East and north Africa. Obesity prevalence was higher than underweight with posterior probability of at least 0·80 in 177 countries (89%) for women and 145 (73%) for men in 2022, whereas the converse was true in 16 countries (8%) for women, and 39 (20%) for men. From 1990 to 2022, the combined prevalence of thinness and obesity decreased among girls in five countries (3%) and among boys in 15 countries (8%) with a posterior probability of at least 0·80, and increased among girls in 140 countries (70%) and boys in 137 countries (69%) with a posterior probability of at least 0·80. The countries with highest combined prevalence of thinness and obesity in school-aged children and adolescents in 2022 were in Polynesia and Micronesia and the Caribbean for both sexes, and Chile and Qatar for boys. Combined prevalence was also high in some countries in south Asia, such as India and Pakistan, where thinness remained prevalent despite having declined. In 2022, obesity in school-aged children and adolescents was more prevalent than thinness with a posterior probability of at least 0·80 among girls in 133 countries (67%) and boys in 125 countries (63%), whereas the converse was true in 35 countries (18%) and 42 countries (21%), respectively. In almost all countries for both adults and school-aged children and adolescents, the increases in double burden were driven by increases in obesity, and decreases in double burden by declining https://researchonline.ljmu.ac.uk/images/research_banner_face_lab_290.jpgunderweight or thinness. Interpretation The combined burden of underweight and obesity has increased in most countries, driven by an increase in obesity, while underweight and thinness remain prevalent in south Asia and parts of Africa. A healthy nutrition transition that enhances access to nutritious foods is needed to address the remaining burden of underweight while curbing and reversing the increase in obesity

A competing survival analysis for housing relocation behaviour and risk aversion in a resilient housing market

Residential relocation decision making is a complicated process, and modelling this complex course of actions requires careful scrutinisation of different aspects. The relocation decision comprises several different decisions, including the reason for the relocation, relocation timing, and attributes of the desired residence. Among these decisions needing to be taken, the reason for relocation and its timing are decided earlier than others. Depending on the variant reasons and motivations for relocating, its timing may be accelerated or decelerated. Relocation usually occurs because of a multiplicity of reasons, which necessitates using a multivariate model for relocation decision making that is jointly modelled with the timing decision. A competing accelerated failure model to jointly formulate these decisions. The housing search literature emphasizes on the importance of considering financial risk acceptance level of decision makers in residential relocation decision models. Therefore, a binary logit model is used to model whether the decision maker is financially risk averse or not. This paper used longitudinal data collected in Australia from the Household, Income, and Labour Dynamics in Australia Survey. Further, the impact of group decision making on residential relocation is captured in this paper through the information provided in Household, Income, and Labour Dynamics in Australia Survey regarding the manner in which decisions are made within households

Willingness to pay for fast charging station for electric vehicles with limited market penetration making

This study investigates the potential public demand for investing in electric vehicles infrastructure using a stated preference method. Availability of electric vehicle fast charging stations can improve consumer penetration and acceptance level of purchasing electric vehicles. The outlook of passenger transport is expected to shift to using electricity as the main fuel source which requires a significant amount of energy through the electricity grid and provision of appropriate public charging infrastructure to help support commuter usage. To quantify the preference of users towards an energy related policy, a discrete choice experiment using a virtual payment system was designed to increment an annual levy amount for specific purpose over a set of years. The results from a sample of 1180 households in New South Wales Australia, revealed that depending on the policy setting, 74.2% of the population would be willing to pay some amount of levy. Moreover, we found that on average NSW households are willing to pay $31.9 as annual levy to help raise the fund to develop and install fast charging station state-wide