Local Ecosystem Service Use and Assessment Vary with Socio-ecological Conditions: A Case of Native Coffee-Forests in Southwestern Ethiopia

Ecosystem-based management requires the promotion and integration of locally relevant ecosystem services. This needs an understanding of which ecosystem services local people value and how local valuation varies with socio-cultural and market factors. We convened ten focus group discussions and performed 105 household surveys from major indigenous groups and recent settlers about local values of various forest-based ecosystem services in changing landscapes of southwest Ethiopia. We found that the extent of ecosystem service use and assessment depends on socio-cultural background and gender of the informants, as well as income and cultural contributions of these services. Ecosystem service values vary in space and time where local people reported that they increasingly value services as they become scarce or in response to increased demands due to emerging markets or changes in production systems. Local people mostly appreciated a few services of high market value while most ecosystem services are not traded in local markets and hence not highly valued. Some low-rated ecosystem services such as fodder and medicinal plants were nonetheless widely used demonstrating the need to also conserve low rated ecosystem services that are used universally. We suggest promoting socio-cultural and other non-marketable ecosystem services to reduce the over-exploitation or exclusion of specific biodiversity components in conservation activities

Challenges and Prospects for Sustainable Forest Management in Wondo Genet Area, Southern Ethiopia

 Natural resources degradation, a major form of which is deforestation and de-vegetation, has become a serious problem in Ethiopia. At present, natural forests cover a tiny fraction of the country’s total area and these are found in small patches mainly in the southern and southwestern parts. Such a patch of forest is found in Wondo Genet area, and it is owned and managed by four major organizations. The forests of these organizations are, however, disappearing at a fast rate which indicates existence of problems in the management approaches of the Organizations. The general objective of this study was to understand existing forest management approaches of the four organizations and indicate some directions towards a sustainable management of the forests. Data were generated through structured questionnaire survey, semi- structured interview, focus group discussion and field observation methods. Various documents from the organizations were also consulted. The results of the study revealed that the four organizations in the area have generally been following a coercive approach, and none of them has, as a result, been successful in protecting the forests from destruction. Lack of a participatory and well-defined management system, increasing scarcity of agricultural land and forest products, inadequacy of benefits to local people from the organizations and ineffectiveness of local administration system in dealing with illegal forest users were the major reasons for the failure. The study concludes by underscoring the need to devise a participatory forest management approach which aims at the co-existence of local people, forest resources and the organizations in the area.  Keywords: forest management, rural livelihoods, participation, sustainability, Wondo Gene

Calcium-dependent intracellular signal pathways in primary cultured adipocytes and ANK3 gene variation in patients with bipolar disorder and healthy controls

Bipolar disorder (BD) is a chronic psychiatric disorder of public health importance affecting >1% of the Swedish population. Despite progress, patients still suffer from chronic mood switches with potential severe consequences. Thus, early detection, diagnosis and initiation of correct treatment are critical. Cultured adipocytes from 35 patients with BD and 38 healthy controls were analysed using signal pathway reporter assays, that is, protein kinase C (PKC), protein kinase A (PKA), mitogen-activated protein kinases (extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK)), Myc, Wnt and p53. The levels of activated target transcriptional factors were measured in adipocytes before and after stimulation with lithium and escitalopram. Variations were analysed in the loci of 25 different single-nucleotide polymorphisms (SNPs). Activation of intracellular signals in several pathways analysed were significantly higher in patients than in healthy controls upon drug stimulation, especially with escitalopram stimulation of PKC, JNK and Myc, as well as lithium-stimulated PKC, whereas no meaningful difference was observed before stimulation. Univariate analyses of contingency tables for 80 categorical SNP results versus diagnoses showed a significant link with the ANK3 gene (rs10761482; likelihood ratio χ(2)=4.63; P=0.031). In a multivariate ordinal logistic fit for diagnosis, a backward stepwise procedure selected ANK3 as the remaining significant predictor. Comparison of the escitalopram-stimulated PKC activity and the ANK3 genotype showed them to add their share of the diagnostic variance, with no interaction (15% of variance explained, P<0.002). The study is cross-sectional with no longitudinal follow-up. Cohorts are relatively small with no medication-free patients, and there are no ‘ill patient' controls. It takes 3 to 4 weeks of culture to expand adipocytes that may change epigenetic profiles but remove the possibility of medication effects. Abnormalities in the reactivity of intracellular signal pathways to stimulation and the ANK3 genotype may be associated with pathogenesis of BD. Algorithms using biological patterns such as pathway reactivity together with structural genetic SNP data may provide opportunities for earlier detection and effective treatment of BD