34 research outputs found
Marked Transient Alkaline Phosphatemia Following Pediatric Liver Transplantation
An isolated marked transient rise in serum alkaline phosphatase levels in otherwise healthy children is a well-documented occurrence. However, in children undergoing liver transplantation, elevated alkaline phosphatase values raise the possibility of biliary obstruction, rejection, or both. During a 6-year period, 6 of 278 children undergoing liver transplantation exhibited a similar phenomenon as an isolated abnormality. None had rejection, biliary obstruction, or other allograft dysfunction during a long follow-up. Eventually and without intervention, the alkaline phosphatase levels returned to normal. These instructive cases suggest that caution be used in advocating invasive procedures if elevated alkaline phosphatase levels are an isolated abnormality, and close observation with noninvasive testing is recommended. © 1989, American Medical Association. All rights reserved
Collider Signatures of the N=3 Lee-Wick Standard Model
Inspired by the Lee-Wick higher-derivative approach to quantum field theory,
Grinstein, O'Connell, and Wise have illustrated the utility of introducing into
the Standard Model negative-norm states that cancel quadratic divergences in
loop diagrams, thus posing a potential resolution of the hierarchy problem.
Subsequent work has shown that consistency with electroweak precision
parameters requires many of the partner states to be too massive to be detected
at the LHC. We consider the phenomenology of a yet-higher derivative theory
that exhibits three poles in its bare propagators (hence N=3), whose states
alternate in norm. We examine the interference effects of W boson partners on
LHC scattering cross sections, and find that the N=3 LWSM already makes
verifiable predictions at 10 fb^(-1) of integrated luminosity.Comment: 15 pages, 4 PDF figures. Version accepted for publication by JHE
Liver transplantation for arteriohepatic dysplasia (Alagille's syndrome)
Thirteen out of 268 children (<18 years old) underwent hepatic transplantation (OLT) for end-stage liver disease (ESLD) associated with arteriohepatic dysplasia (AHD). Seven children are alive and well with normal liver function. Six children died, four within 11 days of the operation and the other two at 4 and 10 months after the OLT. Vascular complications with associated septicemia were responsible for the deaths of three children. Two died of heart failure and circulatory collapse, secondary to pulmonary hypertension and congenital heart disease. The remaining patient died of overwhelming sepsis not associated with technical complications. Seven patients had a portoenterostomy or portocholecystostomy early in life; five of these died after the OLT. Severe cardiovascular abnormalities in some of our patients suggest that complete hemodynamic monitoring with invasive studies should be performed in all patients with AHD, especially in cases of documented hypertrophy of the right ventricle. The improved quality of life in our surviving patients confirms the validity of OLT as a treatment of choice in cases of ESLD due to AHD. © 1992 Springer-Verlag
Reverberation Mapping and the Physics of Active Galactic Nuclei
Reverberation-mapping campaigns have revolutionized our understanding of AGN.
They have allowed the direct determination of the broad-line region size,
enabled mapping of the gas distribution around the central black hole, and are
starting to resolve the continuum source structure. This review describes the
recent and successful campaigns of the International AGN Watch consortium,
outlines the theoretical background of reverberation mapping and the
calculation of transfer functions, and addresses the fundamental difficulties
of such experiments. It shows that such large-scale experiments have resulted
in a ``new BLR'' which is considerably different from the one we knew just ten
years ago. We discuss in some detail the more important new results, including
the luminosity-size-mass relationship for AGN, and suggest ways to proceed in
the near future.Comment: Review article to appear in Astronomical Time Series, Proceedings of
the Wise Observatory 25th Ann. Symposium. 24 pages including 7 figure
The other Higgses, at resonance, in the Lee-Wick extension of the Standard Model
Within the framework of the Lee Wick Standard Model (LWSM) we investigate
Higgs pair production , and top pair
production at the Large Hadron Collider (LHC), where the
neutral particles from the Higgs sector (, and )
appear as possible resonant intermediate states. We investigate the signal and we find that the LW Higgs,
depending on its mass-range, can be seen not long after the LHC upgrade in
2012. More precisely this happens when the new LW Higgs states are below the
top pair threshold. In the LW states, due to the wrong-sign
propagator and negative width, lead to a dip-peak structure instead of the
usual peak-dip structure which gives a characteristic signal especially for
low-lying LW Higgs states. We comment on the LWSM and the forward-backward
asymmetry in view of the measurement at the TeVatron. Furthermore, we present a
technique which reduces the hyperbolic diagonalization to standard
diagonalization methods. We clarify issues of spurious phases in the Yukawa
sector.Comment: 36 pages, 16 figures, 3 table
Uncoupling of Satellite DNA and Centromeric Function in the Genus Equus
In a previous study, we showed that centromere repositioning, that is the shift along the chromosome of the centromeric function without DNA sequence rearrangement, has occurred frequently during the evolution of the genus Equus. In this work, the analysis of the chromosomal distribution of satellite tandem repeats in Equus caballus, E. asinus, E. grevyi, and E. burchelli highlighted two atypical features: 1) several centromeres, including the previously described evolutionary new centromeres (ENCs), seem to be devoid of satellite DNA, and 2) satellite repeats are often present at non-centromeric termini, probably corresponding to relics of ancestral now inactive centromeres. Immuno-FISH experiments using satellite DNA and antibodies against the kinetochore protein CENP-A demonstrated that satellite-less primary constrictions are actually endowed with centromeric function. The phylogenetic reconstruction of centromere repositioning events demonstrates that the acquisition of satellite DNA occurs after the formation of the centromere during evolution and that centromeres can function over millions of years and many generations without detectable satellite DNA. The rapidly evolving Equus species gave us the opportunity to identify different intermediate steps along the full maturation of ENCs
A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)
Meeting abstrac