Stress management in composite biopolymer networks

Living tissues show an extraordinary adaptiveness to strain, which is crucial for their proper biological functioning. The physical origin of this mechanical behaviour has been widely investigated using reconstituted networks of collagen fibres, the principal load-bearing component of tissues. However, collagen fibres in tissues are embedded in a soft hydrated polysaccharide matrix which generates substantial internal stresses whose effect on tissue mechanics is unknown. Here, by combining mechanical measurements and computer simulations, we show that networks composed of collagen fibres and a hyaluronan matrix exhibit synergistic mechanics characterized by an enhanced stiffness and delayed strain-stiffening. We demonstrate that the polysaccharide matrix has a dual effect on the composite response involving both internal stress and elastic reinforcement. Our findings elucidate how tissues can tune their strain-sensitivity over a wide range and provide a novel design principle for synthetic materials with programmable mechanical properties

Radiocarbon measurements of Würm-interstadial samples from Jutland

Der Inhalt von radioaktivem Kohlenstoff in würminterstadialen Proben aus Brörup, Jütland, ist in den Datierungslaboratorien in Kopenhagen und Groningen gemessen worden. Die Proben waren durch verhältnismäßig große Mengen von infiltriertem, jüngeren Material verunreinigt; nach einer Extraktion von Humussäuren zeigte jedoch keine der Proben eine signifikante Aktivität. Dies läßt darauf schließen, daß das Interstadial von Brörup und die vorausgegangene kalte Periode älter als 50 000 Jahre v. Chr. sind. Wenn die Ansicht von Andersen (1957) richtig ist, daß in Brörup wirklich das Göttweiger Interstadial vorliegt, so würde daraus folgen, daß auch Altwürm und wenigstens der tiefere Teil des Göttweiger Interstadials älter als 50 000 Jahre v. Chr. sein müßten.researc

In Memoriam: Jean Luther Laffoon, 1922-1973

Jean L. Laffoon, Professor of Zoology and Entomology at Iowa State University, died January 19, 1973, in Ames, Iowa, after a brief illness. Dr. Laffoon was born in Sioux City Iowa on August 19 1922. He graduated from Central High School, Sioux Citv, in 1939 and was awarded a B.S. degree in biology from Morningside College in 1942. In the fall of that year he entered the University of Michigan, Ann Arbor, but withdrew to volunteer for service in the United States Navy. Upon his discharge, three years later, he enrolled in the Graduate College at Iowa State University, where he earned an M.S. degree in 1948 and a Ph.D. degree in 1953, both in entomology

B polarization of the CMB from Faraday rotation

We study the effect of Faraday rotation due to a homogeneous magnetic field on the polarization of the cosmic microwave background (CMB). Scalar fluctuations give rise only to parity-even E-type polarization of the CMB. However in the presence of a magnetic field, a non-vanishing parity-odd B-type polarization component is produced through Faraday rotation. We derive the exact solution for the E and B modes generated by scalar perturbations including the Faraday rotation effect of a uniform magnetic field, and evaluate their cross-correlations with temperature anisotropies. We compute the angular autocorrelation function of the B-modes in the limit that the Faraday rotation is small. We find that primordial magnetic fields of present strength around $B_0=10^{-9}$G rotate E-modes into B-modes with amplitude comparable to those due to the weak gravitational lensing effect at frequencies around $\nu=30$ GHz. The strength of B-modes produced by Faraday rotation scales as $B_0/\nu^2$. We evaluate also the depolarizing effect of Faraday rotation upon the cross correlation between temperature anisotropy and E-type polarization.Comment: 11 pages, 4 figures. Minor changes to match the published versio

Long Range Hops and the Pair Annihilation Reaction A+A->0: Renormalization Group and Simulation

A simple example of a non-equilibrium system for which fluctuations are important is a system of particles which diffuse and may annihilate in pairs on contact. The renormalization group can be used to calculate the time dependence of the density of particles, and provides both an exact value for the exponent governing the decay of particles and an epsilon-expansion for the amplitude of this power law. When the diffusion is anomalous, as when the particles perform Levy flights, the critical dimension depends continuously on the control parameter for the Levy distribution. The epsilon-expansion can then become an expansion in a small parameter. We present a renormalization group calculation and compare these results with those of a simulation.Comment: As-published version; two significant errors fixed, two references adde

Low-Cost and Readily Available Tissue Carriers for the Boston Keratoprosthesis: A Review of Possibilities

The Boston keratoprosthesis (B-KPro), currently the most commonly used artificial cornea worldwide, can provide rapid visual rehabilitation for eyes with severe corneal opacities not suitable for standard corneal transplantation. However, the B-KPro presently needs a corneal graft as a tissue carrier. Although corneal allograft tissue is readily available in the United States and other developed countries with established eye banks, the worldwide need vastly exceeds supply. Therefore, a simple, safe, and inexpensive alternative to corneal allografts is desirable for the developing world. We are currently exploring reasonable alternative options such as corneal autografts, xenografts, noncorneal autologous tissues, and laboratory-made tissue constructs, as well as modifications to corneal allografts, such as deep-freezing, glycerol-dehydration, gamma irradiation, and cross-linking. These alternative tissue carriers for the B-KPro are discussed with special regard to safety, practicality, and cost for the developing world

A Search for Small-Scale Clumpiness in Dense Cores of Molecular Clouds

We have analyzed HCN(1-0) and CS(2-1) line profiles obtained with high signal-to-noise ratios toward distinct positions in three selected objects in order to search for small-scale structure in molecular cloud cores associated with regions of high-mass star formation. In some cases, ripples were detected in the line profiles, which could be due to the presence of a large number of unresolved small clumps in the telescope beam. The number of clumps for regions with linear scales of ~0.2-0.5 pc is determined using an analytical model and detailed calculations for a clumpy cloud model; this number varies in the range: ~2 10^4-3 10^5, depending on the source. The clump densities range from ~3 10^5-10^6 cm^{-3}, and the sizes and volume filling factors of the clumps are ~(1-3) 10^{-3} pc and ~0.03-0.12. The clumps are surrounded by inter-clump gas with densities not lower than ~(2-7) 10^4 cm^{-3}. The internal thermal energy of the gas in the model clumps is much higher than their gravitational energy. Their mean lifetimes can depend on the inter-clump collisional rates, and vary in the range ~10^4-10^5 yr. These structures are probably connected with density fluctuations due to turbulence in high-mass star-forming regions.Comment: 23 pages including 4 figures and 4 table

Evaluation of early and late presentation of patients with ocular mucous membrane pemphigoid to two major tertiary referral hospitals in the United Kingdom

PURPOSE: Ocular mucous membrane pemphigoid (OcMMP) is a sight-threatening autoimmune disease in which referral to specialists units for further management is a common practise. This study aims to describe referral patterns, disease phenotype and management strategies in patients who present with either early or established disease to two large tertiary care hospitals in the United Kingdom.\ud \ud PATIENTS AND METHODS: In all, 54 consecutive patients with a documented history of OcMMP were followed for 24 months. Two groups were defined: (i) early-onset disease (EOD:<3 years, n=26, 51 eyes) and (ii) established disease (EstD:>5 years, n=24, 48 eyes). Data were captured at first clinic visit, and at 12 and 24 months follow-up. Information regarding duration, activity and stage of disease, visual acuity (VA), therapeutic strategies and clinical outcome were analysed.\ud \ud RESULTS: Patients with EOD were younger and had more severe conjunctival inflammation (76% of inflamed eyes) than the EstD group, who had poorer VA (26.7%=VA<3/60, P<0.01) and more advanced disease. Although 40% of patients were on existing immunosuppression, 48% required initiation or switch to more potent immunotherapy. In all, 28% (14) were referred back to the originating hospitals for continued care. Although inflammation had resolved in 78% (60/77) at 12 months, persistence of inflammation and progression did not differ between the two phenotypes. Importantly, 42% demonstrated disease progression in the absence of clinically detectable inflammation.\ud \ud CONCLUSIONS: These data highlight that irrespective of OcMMP phenotype, initiation or escalation of potent immunosuppression is required at tertiary hospitals. Moreover, the conjunctival scarring progresses even when the eye remains clinically quiescent. Early referral to tertiary centres is recommended to optimise immunosuppression and limit long-term ocular damage.\ud \u