29 research outputs found
Synthesis of some novel enzyme inhibitors and antibacterial agents derived from 5-(1-(4-tosyl)piperidin-4-yl)-1,3,4-oxadiazol-2-thiol
ABSTRACT Keeping in mind the pharmacological importance of the 1,3,4-oxadiazole moiety, a series of new S-substituted derivatives, 5a-h, of 5-(1-(4-tosyl)piperidin-4-yl)-1,3,4-oxadiazol-2-thiol (3) were synthesized. The reaction of p-toluenesulfonyl chloride (a) and ethyl isonipecotate (b) produced ethyl 1-(4-tosyl)piperidin-4-carboxylate (1) which was further transformed into 1-(4-tosyl)piperidin-4-carbohydrazide (2) by hydrazine hydrate in methanol. Compound 2 was refluxed with CS2 in the presence of KOH to synthesize 5-(1-(4-tosyl)piperidin-4-yl)-1,3,4-oxadiazol-2-thiol (3). The desired compounds, 5a-h, were synthesized by stirring 3 with aralkyl halides, 4a-h, in DMF using NaH as an activator. The structures of synthesized compounds were elucidated by 1H-NMR, IR and EI-MS spectral studies. These compounds were further evaluated for enzyme inhibitory activity against lipoxygenase and alpha-glucosidase, along with antibacterial activity against Gram-negative and Gram-positive bacteria
In vitro and in vivo inhibition of human papillomavirus type 16 E6 and E7 genes
Cancer Research55204599-4605CNRE
Kinetics of sulphate conjugation in extracts of human foetal liver cells in culture
Biochemical Pharmacology37244629-4633BCPC
Enhanced potency and efficacy of 29-mer shRNAs in inhibition of Enterovirus 71
10.1016/j.antiviral.2007.01.004Antiviral Research7419-1
Expression patterns of cytokine, growth factor and cell cycle-related after partial hepatectomy in rats with thioacetamide-induced cirrhosis
World Journal of Gastroenterology1271063-1070WJGA
Effects of capsaicin on P-gp function and expression in Caco-2 cells
10.1016/j.bcp.2006.03.024Biochemical Pharmacology71121727-1734BCPC
UDP-Glucuronyltransferase activity toward harmol in human liver and human fetal liver cells in culture
Analytical Biochemistry185144-50ANBC
Mercury-induced UDPglucuronyltransferase (UDPGT) activity in mouse kidney
Toxicology64181-87TXCY
Impact of curcumin-induced changes in P-glycoprotein and CYP3A expression on the pharmacokinetics of peroral celiprolol and midazolam in rats
10.1124/dmd.106.011072Drug Metabolism and Disposition351110-115DMDS
Genome-wide expression profiling of RNA interference of hepatitis B virus gene expression and replication
Cellular and Molecular Life Sciences61162113-2124CMLS