SYNTHESIS OF NIGRICANIN VIA INTRAMOLECULAR BIARYL COUPLING REACTION OF FUNCTIONALIZED PHENYL BENZOATE

A tetracyclic natural product, nigricanin (1), was synthesized through an intramolecular biaryl coupling reaction of the phenyl benzoate derivative which was derived from the corresponding phenol and benzoic acid

ヒフ ランダム セイケン ガ シンダン ニ ユウヨウ デ アッタ ケッカンナイ リンパシュ ノ イチレイ

A６２‐year‐old woman was referred to our hospital for further examination of fever of unknown origin, splenomegaly and pancytopenia. On admission, she had persistent fever and psychological symptoms. Blood examination showed pancytopenia and elevated level of LDH, soluble IL‐２receptor and ferritin. Computed tomography showed multiple low density areas in the spleen, but no systemic lymphadenopathy. In magnetic resonance imaging of the pons, a low and high intensity area on T１‐and T２‐weighted image, respectively, was detected. Taken together these findings, she was suspected to have hepatosplentic T-cell lymphoma or intravascular large B-cell lymphoma. To make a definite diagnosis, random skin biopsy was performed. Immunohistochemical stainings revealed the massive infiltration of CD２０‐and CD７９α‐positive large lymphoid cells inside the vessels, which yielded the diagnosis of intravascular large B-cell lymphoma

Amino-Functionalization of Vinyl-Substituted Aromatic Diimides by Quantitative and Catalyst-Free Hydroamination

Development of facile and versatile synthetic tools for decorating π-conjugated molecules has attracted considerable interest because of their potential application in creating novel π-electron materials. Reported herein are quantitative catalyst-free hydroamination reactions of a series of aromatic diimide compounds having vinyl groups at the π-core, which have been confirmed by NMR, UV–vis absorption spectroscopy, mass analysis, and single crystal X-ray structural analysis. Kinetic studies revealed that the hydroamination reaction of a vinyl-substituted naphthalenediimide with an aliphatic amine proceeded rapidly under benign conditions. Similary, the two vinyl groups attached to aromatic diimides reacted with amines simultaneously, resulting in the formation of amine bisadducts and macromolecules

Simultaneous Tc-99m and I-123 dual-radionuclide imaging with a solid-state detector-based brain-SPECT system and energy-based scatter correction

Background: A brain single-photon emission computed tomography (SPECT) system using cadmium telluride (CdTe) solid-state detectors was previously developed. This CdTe-SPECT system is suitable for simultaneous dual-radionuclide imaging due to its fine energy resolution (6.6 %). However, the problems of down-scatter and low-energy tail due to the spectral characteristics of a pixelated solid-state detector should be addressed. The objective of this work was to develop a system for simultaneous Tc-99m and I-123 brain studies and evaluate its accuracy. Methods: A scatter correction method using five energy windows (FiveEWs) was developed. The windows are Tc-lower, Tc-main, shared sub-window of Tc-upper and I-lower, I-main, and I-upper. This FiveEW method uses pre-measured responses for primary gamma rays from each radionuclide to compensate for the overestimation of scatter by the triple-energy window method that is used. Two phantom experiments and a healthy volunteer experiment were conducted using the CdTe-SPECT system. A cylindrical phantom and a six-compartment phantom with five different mixtures of Tc-99m and I-123 and a cold one were scanned. The quantitative accuracy was evaluated using 18 regions of interest for each phantom. In the volunteer study, five healthy volunteers were injected with Tc-99m human serum albumin diethylene triamine pentaacetic acid (HSA-D) and scanned (single acquisition). They were then injected with I-123 N-isopropyl-4-iodoamphetamine hydrochloride (IMP) and scanned again (dual acquisition). The counts of the Tc-99m images for the single and dual acquisitions were compared. Results: In the cylindrical phantom experiments, the percentage difference (PD) between the single and dual acquisitions was 5.7 +/- 4.0 % (mean +/- standard deviation). In the six-compartment phantom experiment, the PDs between measured and injected activity for Tc-99m and I-123 were 14.4 +/- 11.0 and 2.3 +/- 1.8 %, respectively. In the volunteer study, the PD between the single and dual acquisitions was 4.5 +/- 3.4 %. Conclusions: This CdTe-SPECT system using the FiveEW method can provide accurate simultaneous dual-radionuclide imaging. A solid-state detector SPECT system using the FiveEW method will permit quantitative simultaneous Tc-99m and I-123 study to become clinically applicable

Congenital multiple colonic atresias in the sigmoid colon and upper rectum

Introduction: Congenital colonic atresia develops in 1 in 20,000 to 66,000 births, accounting for 1.8–15% of all intestinal atresias. Approximately 8.9% of patients with colonic atresia have multiple colonic atresias. Case presentation: A female infant with abdominal distention and bilious vomiting did not have a bowel movement until day 3 of life. Plain radiography showed significant dilation of the intestinal tract and no gas in the pelvic cavity. A contrast enema at the age of 3 days showed microcolon and obstruction at the level of the upper rectum. Operative findings included 3 membranous atresias (Type Ⅲ). For the 2 proximal membranous atresias, membranectomy and colostomy in the sigmoid colon were performed. Preoperative contrast enema at 10 months showed a gap between the distal side of the stoma and the blind end of the rectum. The sigmoid colon and rectum were completely resected 6 cm distal to the stoma. Colostomy closure was performed. A total of 4 membranous atresias were present in the sigmoid colon and the upper rectum. Conclusions: In a patient with multiple atresias in the sigmoid colon and upper rectum, multiple-stage surgery could be safe after searching for complicating malformations and evaluating the intestinal tract preoperatively