Constraints on the mass of a habitable planet with water of nebular origin

From an astrobiological point of view, special attention has been paid to the probability of habitable planets in extrasolar systems. The purpose of this study is to constrain a possible range of the mass of a terrestrial planet that can get water. We focus on the process of water production through oxidation of the atmospheric hydrogen--the nebular gas having been attracted gravitationally--by oxide available at the planetary surface. For the water production to work well on a planet, a sufficient amount of hydrogen and enough high temperature to melt the planetary surface are needed. We have simulated the structure of the atmosphere that connects with the protoplanetary nebula for wide ranges of heat flux, opacity, and density of the nebular gas. We have found both requirements are fulfilled for an Earth-mass planet for wide ranges of the parameters. We have also found the surface temperature of planets of <= 0.3 Earth masses is lower than the melting temperature of silicate (~ 1500K). On the other hand, a planet of more than several Earth masses becomes a gas giant planet through runaway accretion of the nebular gas.Comment: 25 pages, 8 figures, to appear in the 01 September 2006 issue of Ap

The Steady Two-dimensional Flow of Viscous Incompressible Fluid Past an Elliptic Valve of Zero Angle of Attack Placed in a Rectilinear Channel : As a Model of a Flow Past a Fully Open Butterfly Valve

We studied the steady two-dimensional flow of a viscous incompressibe fluid past an elliptic valve of zero angle of attack placed in a rectilinear channel. We apply generalized curvilinear coordinates, by which the channel walls and the valve surface are mapped onto corresponding coordinate lines, to the solution of the stream function-vorticity formulation of the Navier-Stokes equations. The ADI and the Euler explicit method of solution are applied to solve the transformed basic equations. Flow patterns, pressure distributions and drag coefficients are obtained for several values of Reynolds number between 0 and 40

Numerical Solution of Two-dimensional Channel Flow of Viscous Incompressible Fluid past an Elliptic Cylinder

We studied a two-dimensional flow of viscous incompressible fluid past a thin elliptic cylinder in a rectilinear channel. The major axis of the cylinder has the same length as the channel width, and the center of the cylinder is placed on the midplane of the channel. Reynolds number R and the angle of attack θ of the cylinder range, respectively, between 50 and 1000 and between 0° and 40°. The new upwind difference scheme by Kawamura Kuwahara (1984) is applied to the stream function-vorticity formalism of the Navier-Stokes equations. The boundary-fitted curvilinear coordinate systems by Thompson et al (1976) are used to transform the physical plane onto a simple calculation plane. The line-Jacobi method of iteration is applied to the solution of the Poisson type equation of the stream function. The Euler explicit method of solution is applied to the solution of the vorticity equation

Effects of Interval Time of the Epley Manoeuvre

Objective: The Epley maneuver (EM) has an immediate effect: rapid reduction of positional nystagmus. Benign paroxysmal positional vertigo (BPPV) causes BPPV fatigue, which constitutes fatigability of positional nystagmus and vertigo with repeated performance of the Dix-Hallpike test; notably, BPPV fatigability becomes ineffective over time. We hypothesized that the immediate effect of the EM is caused by BPPV fatigue. Therefore, we suspected that performance of the EM with intervals between head positions would worsen the immediate reduction of positional nystagmus in patients with BPPV, because BPPV fatigability would become ineffective during performance of this therapy. Methods: Forty patients with newly diagnosed BPPV were randomly assigned to the following two groups; one group performed the EM without intervals between positions (group A), and the other group performed the EM with 3 min intervals between positions (group B). The primary outcome measure was the ratio of maximum slow-phase eye velocity (MSPEV) of positional nystagmus soon after the EM, compared with that measured before the EM. Secondary outcome included whether a 30 min interval after the EM enabled recovery of MSPEV of positional nystagmus to the original value. This study followed the CONSORT 2010 reporting standards. Results: In both groups A and B, the immediate effect of the EM could be observed, because MSPEV during the second Dix-Hallpike test was significantly smaller than MSPEV during the first Dix-Hallpike test (p < 0.0001 in group A, p < 0.0001 in group B). The primary outcome measure was larger in group B than in group A (p = 0.0029). The immediate effect faded 30 min later (secondary outcome). Conclusions: This study showed that the EM had an immediate effect both with and without interval time in each head position of the EM. Because setting interval time in each head position of the EM reduced the immediate effect of the EM, interval time during the EM adds less benefit. This finding can reduce the effort exerted by doctors, as well as the discomfort experienced by patients with pc-BPPV, during EM. However, this immediate effect may be caused by BPPV fatigue, and may fade rapidly

Asymmetric Synthesis of N-Fmoc-(S)-7-aza-tryptophan via Alkylation of Chiral Nucleophilic Glycine Equivalent

Ni(II)-complexes, derived from glycine Schiff bases with chiral tridentate ligands, have been used as powerful tools for the synthesis of structurally diverse tailor-made amino acids. In this manuscript, asymmetric alkylation reaction between chiral nucleophilic glycine derived Ni-complex and 3-(chloromethyl)-1H-pyrrolo[2,3-b]pyridine has been developed under convenient conditions, which affords the corresponding alkylated Ni-complex in 74 % yield and excellent diastereoselectivity (only one isomer). This reaction features convenient conditions and completely controlled diastereoselectivity, which provides a highly valuable approach for asymmetric synthesis of 7-aza-tryptophan

Analysis on Steady-State Vibration of Nonlinear System by Convolution Integral

A method for analyzing steady state vibration of a system with localized nonlinear springs by convolution integral is proposed. Scale of the nonlinear problem can be reduced by using localization of the nonlinear springs in the method. First, equation of motion with the convolution integral of nonlinear restoring force which is treated as an external force is made, second, a set of nonlinear algebraic equations on discrete-time history of unit period is derived and finally the nonlinear algebraic equations is solved with the harmonic balance method. Stable and unstable condition of the steady state vibration can be distinguished by the present method and the impulse response required can be also measured in the experiment because of the merit of the convolution integral. Two examples are shown and the validity of the method is discussed in comparison with Runge-Kutta-Gill method or the experiment. © 2000, The Japan Society of Mechanical Engineers. All rights reserved

Gram Staining for the Treatment of Peritonsillar Abscess

Objective. To examine whether Gram staining can influence the choice of antibiotic for the treatment of peritonsillar abscess. Methods. Between 2005 and 2009, a total of 57 cases of peritonsillar abscess were analyzed with regard to cultured bacteria and Gram staining. Results. Only aerobes were cultured in 16% of cases, and only anaerobes were cultured in 51% of cases. Mixed growth of aerobes and anaerobes was observed in 21% of cases. The cultured bacteria were mainly aerobic Streptococcus, anaerobic Gram-positive cocci, and anaerobic Gram-negative rods. Phagocytosis of bacteria on Gram staining was observed in 9 cases. The bacteria cultured from these cases were aerobic Streptococcus, anaerobic Gram-positive cocci, and anaerobic Gram-negative rods. The sensitivity of Gram staining for the Gram-positive cocci and Gram-negative rods was 90% and 64%, respectively. The specificity of Gram staining for the Gram-positive cocci and Gram-negative rods was 62% and 76%, respectively. Most of the Gram-positive cocci were sensitive to penicillin, but some of anaerobic Gram-negative rods were resistant to penicillin. Conclusion. When Gram staining shows only Gram-positive cocci, penicillin is the treatment of choice. In other cases, antibiotics effective for the penicillin-resistant organisms should be used

KLHDC10 Activates ASK1 by Suppressing PP5

Reactive oxygen species (ROS)-induced activation of Apoptosis signal-regulating kinase 1 (ASK1) plays crucial roles in oxidative stress-mediated cell death through the activation of the JNK and p38 MAPK pathways. However, the regulatory mechanism of ASK1 in the oxidative stress response remains to be elucidated. Here, we identified the kelch repeat protein, Slim, as an activator of ASK1 through a Drosophila misexpression screen. We also performed a proteomics screen and revealed that Kelch domain containing 10 (KLHDC10), a mammalian ortholog of Slim, interacted with Protein phosphatase 5 (PP5), which has been shown to inactivate ASK1 in response to ROS. KLHDC10 bound to the phosphatase domain of PP5 and suppressed its phosphatase activity. Moreover, KLHDC10 was required for H2O2-induced sustained activation of ASK1 and cell death in Neuro2A cells. These findings suggest that Slim/KLHDC10 is an activator of ASK1, contributing to oxidative stress-induced cell death through the suppression of PP5

VOG to Measure 3D Rotation Vector of Murine Eye Movements

Background The mouse is the most commonly used animal model in biomedical research because of recent advances in molecular genetic techniques. Studies related to eye movement in mice are common in fields such as ophthalmology relating to vision, neuro-otology relating to the vestibulo-ocular reflex (VOR), neurology relating to the cerebellum’s role in movement, and psychology relating to attention. Recording eye movements in mice, however, is technically difficult. Methods We developed a new algorithm for analyzing the three-dimensional (3D) rotation vector of eye movement in mice using high-speed video-oculography (VOG). The algorithm made it possible to analyze the gain and phase of VOR using the eye’s angular velocity around the axis of eye rotation. Results When mice were rotated at 0.5 Hz and 2.5 Hz around the earth’s vertical axis with their heads in a 30° nose-down position, the vertical components of their left eye movements were in phase with the horizontal components. The VOR gain was 0.42 at 0.5 Hz and 0.74 at 2.5 Hz, and the phase lead of the eye movement against the turntable was 16.1° at 0.5 Hz and 4.88° at 2.5 Hz. Conclusions To the best of our knowledge, this is the first report of this algorithm being used to calculate a 3D rotation vector of eye movement in mice using high-speed VOG. We developed a technique for analyzing the 3D rotation vector of eye movements in mice with a high-speed infrared CCD camera. We concluded that the technique is suitable for analyzing eye movements in mice. We also include a C++ source code that can calculate the 3D rotation vectors of the eye position from two-dimensional coordinates of the pupil and the iris freckle in the image to this article