129 Xe NMR of xenon trapped in fully dehydrated mesoporous silica

129Xe NMR spectra of natural abundant xenon gas trapped in fully dehydrated mesoporous materials with pore sizes smaller than 2 nm in diameter were observed under atmospheric pressure in the temperature range between 168 and 373 K. The average pore diameters of the materials studied in this paper were 0.5, 1 and about 2 nm for molecular sieves 5A and 13X and synthesized mesoporous silica, respectively. The samples were fully dehydrated using an ultra-high vacuum (UHV) system and xenon gas was introduced with the sample pre-cooled to 168 K just above the boiling point of xenon. The 129Xe NMR spectra were observed as a function of increasing temperature and the 129Xe shift were observed at each temperature for the three samples under atmospheric pressure. The behaviors of xenon atoms in small pores observed in equilibrium states can provide important information on relationships between the pore structure and 129Xe chemical shift

Lactams. XIX. The Alkaline Ferricyanide Oxidation of 1,3-Disubstituted Pyridinium Salts : Effects of Branched Alkyl Groups at the 3-Position

In the oxidation of 3-substituted 1-methylpyridinium salts (type III) with potassium ferricyanide and KOH at 32℃, the isopropyl and the tert-butyl group at the 3-position were found to orient oxidation to both the 2-(type IV) and the 6-position (type V) in ratios of 71 : 29 and 14 : 86,respectively. In the oxidation of the 1-methyl-3-tert-butyl-pyridinium salt (IIIl), replacement of the 1-methyl group by an aralkyl group along the series benzyl, phenethyl, and 3,4-dimethoxyphenethyl decreased the extent of the 2-pyridone formation along the series

Lactams. XVIII. Oxidation of 1-Substituted 3-tert-Butyl-piperidine with Mercuric Acetate-EDTA

1-(3,4-Dimethoxyphenyl)-2-(3-tert-butylpiperidino) ethanol (7) was prepared from 3-tert-butylpyridine (5) through the quaternary salt 6. The mercuric acetate-EDTA oxidation of 7 produced the 6-piperidone 10 and the 2-piperidone 13 in a ratio of 98 : 2. The former piperidone was chemically correlated with the known 6-pyridone 8 through the lactam 9,and 9 was converted into the benzoquinolizidine 11 by cyclization and reduction of the resulting iminium salt 12

Synthesis of 3-tert-Butylpyridine

3-tert-Butylpyridine (11) has been synthesized from neopentyl alcohol in 16% overall yield through a five-step sequence. Among the steps involved are the cycloaddition of α-tert-butylacrolein (9) to butyl vinyl ether and conversion of the resulting dihydropyran derivative (10) into the pyridine base (11)

心臓血管外科領域におけるゼラチンシートの止血効果、癒着防止効果の検討

BACKGROUND:The bi1ayer gelatin sealing sheet was developed as a safe, effective, easy-to-handle and low-cost hemostatic agent. OBJECTIVE:To examine the feasibility of gelatin sealing sheets using a canine aterial hemorrhage mode1. METHODS:In vivo degradation of gelatin sealing sheets was examined by implanting subcutaneously in rats. For the hemostatic and anti-adhesion efficacy investigations, femoral arteries of dogs were pricked with syringe needle to make as mall hole, and a gelatin(i.e. experimental group) or fibrin glue sealing sheet (i.e. control group) was applied on the hole to stop bleeding (n=8). After discontinuation of the bleeding, the skin incisions were closed and re-examined 4 weeks postoperatively. RESULTS:From the degradation study, 4h thermally treated gelatin sheet which degraded within 3 weeks in vivo was chosen for the further hemostatic study. In all cases of gelatin and fibrin glue sealing sheets, bleeding from the needle hole on canine femoral arteries was effectively stopped. Postoperative adhesions and inflammation at the site in the experimental group were significantly less than those in the control group (P<0.01 for adhesion scores). CONCLUSIONS:The gelatin sealing sheet was found to be as effective as the fibrin glue sealing sheet as a surgical hemostatic agent, and more effective in preventing postoperative adhesions.博士（医学）・甲第632号・平成27年3月16日Copyright ©2015 IOS Pres

The ASTRO-H X-ray Observatory

The joint JAXA/NASA ASTRO-H mission is the sixth in a series of highly successful X-ray missions initiated by the Institute of Space and Astronautical Science (ISAS). ASTRO-H will investigate the physics of the high-energy universe via a suite of four instruments, covering a very wide energy range, from 0.3 keV to 600 keV. These instruments include a high-resolution, high-throughput spectrometer sensitive over 0.3-2 keV with high spectral resolution of Delta E < 7 eV, enabled by a micro-calorimeter array located in the focal plane of thin-foil X-ray optics; hard X-ray imaging spectrometers covering 5-80 keV, located in the focal plane of multilayer-coated, focusing hard X-ray mirrors; a wide-field imaging spectrometer sensitive over 0.4-12 keV, with an X-ray CCD camera in the focal plane of a soft X-ray telescope; and a non-focusing Compton-camera type soft gamma-ray detector, sensitive in the 40-600 keV band. The simultaneous broad bandpass, coupled with high spectral resolution, will enable the pursuit of a wide variety of important science themes.Comment: 22 pages, 17 figures, Proceedings of the SPIE Astronomical Instrumentation "Space Telescopes and Instrumentation 2012: Ultraviolet to Gamma Ray