食物アレルゲンの消化管吸収と経口感作におよぼす非ステロイド性抗炎症薬の影響解析

広島大学(Hiroshima University)博士(薬学)Doctor of Philosophy in Pharmaceutical Sciencedoctora

Rubeosis Iridis Resulting from Agenesis of the Internal Carotid Artery: A Case Report

We report a case of rubeosis iridis resulting from agenesis of the internal carotid artery. Agenesis of the internal carotid artery is a rare congenital anomaly, and most patients do remain asymptomatic, but we should realize that this condition may lead to ocular ischemic changes, the result being rubeosis iridis

The quarkynic phase and the Z_{Nc} symmetry

We investigate the interplay between the Z_{Nc} symmetry and the emergence of the quarkyonic phase, adding the flavor-dependent complex chemical potentials \mu_f=\mu+iT\theta_f with (\theta_f)=(0, \theta, -\theta) to the Polyakov-loop extended Nambu-Jona-Lasinio (PNJL) model. When \theta=0, the PNJL model with the \mu_f agrees with the standard PNJL model with the real chemical potential \mu. When \theta=2\pi/3, meanwhile, the PNJL model with the \mu_f has the Z_{Nc} symmetry exactly for any real \mu, so that the quarkyonic phase exists at small T and large \mu. Once \theta varies from 2\pi/3, the quarkyonic phase exists only on a line of T=0 and \mu larger than the dynamical quark mass, and the region at small T and large \mu is dominated by the quarkyonic-like phase in which the Polyakov loop is small but finite.Comment: 5 pages, 6 figure

Combined Therapy for Anti-N-methyl D-aspartate Receptor Encephalitis

Background Anti-N-methyl- d-aspartate receptor (anti-NMDAR) encephalitis is an autoimmune neurological disorder that usually occurs as a paraneoplastic syndrome and is particularly associated with ovarian teratoma. Standard therapy for severe cases is not established and the prognosis in patients who do not respond to first-line treatment is poor. Case Report An 11-year-old boy complained psychiatric symptoms and rapidly lost consciousness. CT scan revealed mediastinal teratoma and serum/spinal fluid was positive for anti-NMDAR antibody. He kept comatose and his brain stem function was profoundly disturbed. His symptoms were refractory to first-line therapy, which involved tumor resection, methylprednisolone (mPSL) pulse, Intravenous immunoglobulin (IVIG), and plasma exchange. We administered a combination therapy of rituximab and cyclophosphamide as second-line therapy and achieved complete recovery without adverse effects related to treatment. Conclusion  We consider early intensive treatment with a combination of rituximab and cyclophosphamide to be a safe and effective option for severe cases of anti-NMDAR encephalitis