Oleamycins A and B: new antibacterial cyclic hexadepsipeptides isolated from a terrestrial Streptomyces sp.

Actinomycetes have been a source for anti-infectives for more than 50 years, and continue to have a very important role as the source organisms for the discovery of new antibiotics. In the course of our screening program for the discovery of new antibacterial compounds, one such strain (Lv20-58), recovered from the root zone of the plant 0/caceae europea came to our attention

Peptides with anticancer use or potential.: Peptides with anticancer use or potential.

International audienceThis review is an attempt to illustrate the diversity of peptides reported for a potential or an established use in cancer therapy. With 612 references, this work aims at covering the patents and publications up to year 2000 with many inroads in years 2001-2002. The peptides are classed according to four categories of effective (or plausible) biological mechanisms of action: receptor-interacting compounds; inhibitors of protein-protein interaction; enzymes inhibitors; nucleic acid-interacting compounds. The fifth group is made of the peptides for which no mechanism of action has been found yet. Incidentally this work provides an overview of many of the modern targets of anticancer research