27 research outputs found
Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation
We carried out a trans-ancestry genome-wide association and replication study of blood pressure phenotypes among up to 320,251 individuals of East Asian, European and South Asian ancestry. We find genetic variants at 12 new loci to be associated with blood pressure (P = 3.9 × 10-11 to 5.0 × 10-21). The sentinel blood pressure SNPs are enriched for association with DNA methylation at multiple nearby CpG sites, suggesting that, at some of the loci identified, DNA methylation may lie on the regulatory pathway linking sequence variation to blood pressure. The sentinel SNPs at the 12 new loci point to genes involved in vascular smooth muscle (IGFBP3, KCNK3, PDE3A and PRDM6) and renal (ARHGAP24, OSR1, SLC22A7 and TBX2) function. The new and known genetic variants predict increased left ventricular mass, circulating levels of NT-proBNP, and cardiovascular and all-cause mortality (P = 0.04 to 8.6 × 10-6). Our results provide new evidence for the role of DNA methylation in blood pressure regulation
Infrared and x-ray photoelectron spectroscopy studies of as-prepared and furnace-annealed radio-frequency sputtered amorphous silicon carbide films
Journal of Applied Physics8394968-4973JAPI
Electrical and structural properties of rapid thermal annealed amorphous silicon carbide films
Physica Status Solidi (A) Applied Research169167-76PSSA
Non-ionic radiologic contrast (iohexol) interferes with laboratory measurements of endocrine hormones
10.1097/PAT.0b013e32836359e1Pathology455527-529PTLG
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Coalescing plaques on the face, trunk, and upper extremities
Open access journalThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]
Infra-red, X-ray photoelectron spectroscopy and electrical studies of r.f. sputtered amorphous silicon carbide films
Thin Solid Films343-3441-2441-444THSF
Choroidal thickness and risk characteristics of eyes with myopic choroidal neovascularization
10.1111/aos.12117Acta Ophthalmologica917e580-e58
Use of GoPro point-of-view camera in intubation simulation—A randomized controlled trial
10.1371/journal.pone.0243217PLoS ONE1512-Dece024321
Molten synthesis of ZnO.Fe3O4 and Fe 2O3 and its electrochemical performance
10.1016/j.electacta.2013.11.125Electrochimica Acta11875-80ELCA