14 research outputs found
Nuclear Interactions Of Super High Energy Cosmic-rays Observed In Mountain Emulsion Chambers
Here we present a summary of joint discussions on the results of three mountain experiments with large-scale emulsion chambers, at Pamir, Mt. Fuji and Chacaltaya. Observations cover gamma quanta, hadrons and their clusters (called "families"). The following topics are covered, concerning the characteristics of nuclear interactions the energy region 1014-1016 eV: (i) rapid dissipation seen in atmospheric diffusion of high-energy cosmic-rays; (ii) multiplicity and Pt increase in produced pi-mesons in the fragmentation region; (iii) existence of large-Pt jets, (iv) extremely hadron-rich family of the Centauro type; (v) exotic phenomena in the extremely high energy region beyond 1016 eV. Β© 1981.1911125(1977) Acta Univ. Lodz ser. II, (60)(1973) 13th Int. Cosmic-ray Conf., 3, p. 2228(1975) 14th Int. Cosmic-Ray Conf., 7, p. 2365(1979) AIP Conf. Proc. no. 49, p. 334(1979) 16th Int. Cosmic-ray Conf., 6, p. 344(1979) 16th Int. Cosmic-ray Conf., 7, p. 6816th Int. Cosmic-ray Conf. (1979) 16th Int. Cosmic-ray Conf., 7, p. 284(1979) 16th Int. Cosmic-ray Conf., 7, p. 294(1979) 16th Int. Cosmic-ray Conf., 13, p. 87(1979) 16th Int. Cosmic-ray Conf., 13, p. 92(1979) 16th Int. Cosmic-ray Conf., 13, p. 98(1979) AIP Conf. Proc. no. 49, p. 94(1979) AIP Conf. Proc. no. 49, p. 145(1979) AIP Conf. Proc. no. 49, p. 317(1979) 16th Int. Cosmic-ray Conf., 6, p. 350(1979) 16th Int. Cosmic-ray Conf., 6, p. 356(1979) 16th Int. Cosmic-ray Conf., 6, p. 362Nikolsky, Proc. 9th Int. High-energy Symp. (1978) CSSR, 21. , ToborMiyake, (1978) Proc. 19th Int. Conf. on High-energy physics, p. 433Vernov, (1977) Physica, 3, p. 1601Khristiansen, (1978) JETP Lett., 28, p. 124(1973) 13th Int. Cosmic-ray Conf., 3, p. 2219Izv. Acad. Nauk USSR, ser Phys. (1974) Izv. Acad. Nauk USSR, ser Phys., 38, p. 918(1975) 14th Int. Cosmic-ray Conf., 7, p. 2365(1979) 16th Int. Cosmic-ray Conf., 7, p. 68Dunaevsky, Urysson, Emelyanov, Shorin, Tashimov, (1975) FIAN preprint no. 150Dunaevsky, Urysson, Emelyanov, Shorin, Tashinov, (1979) Acta Univ. Lodz ser. II, (60), p. 199Ivanenko, Kanevskya, Roganova, (1978) JETP Lett., 40, p. 704Ivanenko, Kanevsky, Roganova, (1979) 16th Int. Cosmic-ray Conf., 7, p. 101Ivanenko, Kanevsky, Roganova, (1979) 16th Int. Cosmic-ray Conf., 7, p. 198Wrotniak, (1977) Acta Univ. Lodz ser. II, (60), p. 165Krys, Tomaszevski, Wrotniak, (1979) 16th Int. Cosmic-ray Conf., 7, p. 182Krys, Tomaszevski, Wrotniak, (1979) 16th Int. Cosmic-ray Conf., 7, p. 186Fomin, Kempa, Khristiansen, Levina, Piotrowska, Wdowczyk, (1977) 15th Int. Cosmic-ray Conf., 7, p. 248Fomin, Kempa, Khristiansen, Levina, Piotrowska, Wdowczyk, (1979) 16th Int. Cosmic-ray Conf., 13, p. 82Azimov, Mullazhanov, Yuldashbayev, (1979) 16th Int. Cosmic-ray Conf., 7, p. 262Azimov, Mullazhanov, Yuldashbayev, (1977) Acta Univ. Lodz ser. II, (60), p. 275Kasahara, Torri, Yuda, (1979) 16th Int. Cosmic-ray Conf., 13, p. 70Kasahara, Torii, Yuda, (1979) 16th Int. Cosmic-ray Conf., 13, p. 79Shibata, (1979) 16th Int. Cosmic-ray Conf., 7, p. 176H. Semba, T. Shibata and T. Tabuki, Suppl. Prog. Theor. Phys., to be publishedZhdanov, Roinishvilli, Smorodin, Tomaszevski, (1975) FIAN preprint no. 163Lattes, Fujimoto, Hasegawa, Hadronic interactions of high energy cosmic-ray observed by emulsion chambers (1980) Physics Reports, 65, p. 152Ellsworth, Gaisser, Yodh, (1981) Phys. Rev., 23 D, p. 764Baradzei, Smorodin, (1974) FIAN preprint nos. 103, 104Baradzei, Smorodin, (1977) Acta Univ. Lodz ser. II, (60), p. 51Zhdanov, (1980) FIAN preprint no. 140H. Semba, T. Shibata and T. Tabuki, Suppl. Prog. Theor. Phys., to be publishedShibata, (1980) Phys. Rev., 22 D, p. 100Slavatinsky, (1980) Proc. 7th European Symp. on Cosmic rays, , Leningrad, to be published(1979) AIP Conference Proc. no. 49, p. 145Azimov, Abduzhamilov, Chudakov, (1963) JETP (Sov. Phys.), 45, p. 40713th Int. Cosmic-ray Conf. (1973) 13th Int. Cosmic-ray Conf., 5, p. 326Acharya, Rao, Sivaprasad, Rao, (1979) 16th Int. Cosmic-ray Conf., 6, p. 289Ellsworth, Goodman, Yodh, Gaisser, Stanev, (1981) Phys. Rev., 23 D, p. 771Bariburina, Guseva, Denisova, (1980) Acta Univ. Lodz, 1, p. 9415th Int. Cosmic-ray Conf. (1977) 15th Int. Cosmic-ray Conf., 7, p. 184(1979) AIP Conf. Proc. no. 49, p. 33
Observation Of A High-energy Cosmic-ray Family Caused By A Centauro-type Nuclear Interaction In The Joint Emulsion Chamber Experiment At The Pamirs
An exotic cosmic-ray family event is observed in the large emulsion chamber exposed by the joint at the Pamirs (4360 m above sea level). The family is composed of 120Ξ³-ray-induced showers and 37 hadron-induced showers with individual visible energy exceeding 1 TeV. The decisive feature of the event is the hadron dominance: Ξ£EΞ³, Ξ£E(Ξ³) h, γEΞ³, γE(Ξ³) hγ, γEΞ³Β·RΞ³γ and γE(Ξ³)Β·Rhγ being 298 TeV, 476 TeV, 2.5 TeV, 12.9 TeV, 28.6 GeV m and 173 GeV m, respectively. Most probably the event is due to a Centauro interaction, which occured in the atmosphere at βΌ700 m above the chamber. The event will constitute the second beautiful candidate for a Centauro observed at the Pamirs. Β© 1987.1901-2226233Bayburina, (1981) Nucl. Phys. B, 191, p. 1Lattes, Fujimoto, Hasegawa, Hadronic interactions of high energy cosmic-ray observed by emulsion chambers (1980) Physics Reports, 65, p. 151(1984) Trudy FIAN, 154, p. 1Borisov, (1984) Proc. Intern. Symp. on Cosmic rays and particle physics, p. 3. , TokyoRen, (1985) 19th Intern. Cosmic ray Conf., 6, p. 317. , La JollaYamashita, (1985) 19th Intern. Cosmic ray Conf., 6, p. 364. , La JollaTamada, (1977) Nuovo Cimento, 41 B, p. 245T. Shibata et al., to be publishedHillas, (1979) 16th Intern. Cosmic ray Conf., 6, p. 13. , KyotoBattiston, Measurement of the proton-antiproton elastic and total cross section at a centre-of-mass energy of 540 GeV (1982) Physics Letters B, 117, p. 126UA5 Collab., G.J. Alner et al., preprint CERN-EP/85-62Taylor, (1976) Phys. Rev. D, 14, p. 1217Burnett, (1984) Proc. Intern. Symp. on Cosmic rays and particle physics, p. 468. , Toky
MODEL FOR FORMING THE INTERREGIONAL CLUSTER OF THE ALTERNATIVE ENERGY
The relevance of the research is due to the necessity of improving Russia's environmental and economic policy at the present stage and ensuring sustainable environmental and economic development of the Russian economy. One of the main strategic priorities of the latter is the development of alternative energy, which will contribute to higher energy and environmental efficiency as well as to easing the load on the environment. It will also involve optimization of the structure of the country's balance of energy owing to reducing its dependence on the export of organic fuels and to ensuring innovation development of the energy industry for the long term. With regard to this, the paper is aimed at finding the most efficient way for solving the said problem; as one, it is shaping the interregional cluster of alternative energy that is suggested by the authors. The leading approach to studying this problem is the systemic approach enabling an integrated view of the diverse elements (alternative energy, cluster approach, interregional interaction) that used to be considered individually. In the paper, the necessity of developing alternative energy is justified as one of the focus areas for ensuring Russia's sustainable environmental and economic development which requires the relevant material, labor and financial resources, technologies and equipment. In order to generate these, it is suggested to form the interregional cluster of alternative energy based on one of the four presented interregional interaction models, namely, the multilateral cross-sectoral model which is going to incorporate mutually associated sectors of the economy (producer sectors, supplier sectors, and consumer sectors) located in several regions and aimed at solving the shared problems. The materials of the paper are of practical value for the state and municipal authorities of Russia in terms of improving the policy implemented by them within sustainable development. Moreover, the results of the paper can be taken into account in forming an entire range of regulatory instruments and social and economic development programs for Russia in general and its regions in particular
Green and Resilient City: Obligatory Requirements and Voluntary Actions in Moscow
The interest to the sustainable development, resilience and smartness of cities and communities has been growing globally since 1980s. City governments have been working out strategies, forming unions and associations, and exchanging experience in facing urbanization challenges and managing city assets sustainably. Authors consider international initiatives and standards providing for the common background needed to work out and implement sustainable development and resilience strategies and management plans as well as to assess and compare results achieved. Major initiatives analyzed include the United Nations HABITAT Program, the International βGreen City Indexβ research, the network of the worldβs megacities committed to addressing climate change (C40), the Charter of European Cities and Towns Towards Sustainability (Aalborg Charter) and the Working Group on Environmentally Sustainable Cities of Association of Southeast Asian Nations. A new series of the International Organization for Standardization standards ISO 37000 establishing requirements to management systems for sustainable development of communities and offering guidance in setting aims and objectives and measuring success is considered. Peculiarities of the understanding and use of these standards in Russia are described. Authors study a wide range of legal requirements set by Moscow city government in the period of 1993β2018 and demonstrate advantages and shortcoming of the legal acts passed and enforced. Consider voluntary actions undertaken by the local community, non-governmental organizations and educational establishments. The Chapter demonstrates the need for systematizing patchy policy documents and research projects. The case for the restoration of Moscow water bodies (small rivers) as backbones of the urban ecological network will be elaborated. Β© 2020, Springer Nature Switzerland AG
MODERN APPROACHES TO ORGANIZATION OF SUPPLEMENTAL FEEDING FOR THE CHILDREN, SUFFERING FROM FOOD INTOLERANCE AND ALIMENTARY DEPENDENT DISEASES
The article highlights the issues related to the prescription of supplemental feeding to the children with various pathology: food intolerance (food allergy, lactase deficiency, gluten sensitive enteropathy) and alimentary dependent diseases (iron deficiency anemia, oligotrophy). The authors substantiated the necessity and expediency of supplemental feeding introduction. They also examined the basic principles of its purpose. The authors described the peculiarities of each of the supplemental feeding groups and noted the expediency of manufactured product use. Along with that, they pointed out to the dependence of terms and order, in which different products and dishes of supplemental feeding are introduced, upon the character of the disease and the nutritive status of a child.Key words: children, supplemental feeding, manufactured Supplemental feeding products, food intolerance, alimentary dependent diseases.</strong
MODERN APPROACHES TO ORGANIZATION OF SUPPLEMENTAL FEEDING FOR THE CHILDREN, SUFFERING FROM FOOD INTOLERANCE AND ALIMENTARY DEPENDENT DISEASES
The article highlights the issues related to the prescription of supplemental feeding to the children with various pathology: food intolerance (food allergy, lactase deficiency, gluten sensitive enteropathy) and alimentary dependent diseases (iron deficiency anemia, oligotrophy). The authors substantiated the necessity and expediency of supplemental feeding introduction. They also examined the basic principles of its purpose. The authors described the peculiarities of each of the supplemental feeding groups and noted the expediency of manufactured product use. Along with that, they pointed out to the dependence of terms and order, in which different products and dishes of supplemental feeding are introduced, upon the character of the disease and the nutritive status of a child.Key words: children, supplemental feeding, manufactured Supplemental feeding products, food intolerance, alimentary dependent diseases
Π Π°ΡΡΠ²ΠΎΡΠΈΠΌΡΠΉ ΡΠ΅ΡΠ΅ΠΏΡΠΎΡ ΠΏΠΎΠ΄Π°Π²Π»Π΅Π½ΠΈΡ ΡΡΠΌΠΎΡΠΎΠ³Π΅Π½Π½ΠΎΡΡΠΈ Π²ΡΠΎΡΠΎΠ³ΠΎ ΡΠΈΠΏΠ° (sST2) β Π½ΠΎΠ²ΡΠΉ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΡΠΉ Π±ΠΈΠΎΠΌΠ°ΡΠΊΠ΅Ρ ΠΏΠΎΠ»ΠΎΠΆΠΈΡΠ΅Π»ΡΠ½ΡΡ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ² ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΡΠ΅ΡΠ΄Π΅ΡΠ½ΠΎΠΉ ΡΠ΅ΡΠΈΠ½Ρ ΡΠΎΠ½ΠΈΠ·ΠΈΡΡΡΡΠ΅ΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΠΈ ΠΌΠΎΠ΄ΡΠ»ΡΡΠΈΠΈ ΡΠ΅ΡΠ΄Π΅ΡΠ½ΠΎΠΉ ΡΠΎΠΊΡΠ°ΡΠΈΠΌΠΎΡΡΠΈ Ρ Π±ΠΎΠ»ΡΠ½ΡΡ Ρ ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠ΅ΡΠ΄Π΅ΡΠ½ΠΎΠΉ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎΡΡΡΡ
Background: According to numerous studies, from 30% to 50% of patients with chronic heart failure (CHF) are resistant to cardiac resynchronization therapy (CRT) and cardiac contractility modulation (CCM), despite their careful selection in accordance with current guidelines. It is of interest to study neurohormones characterizing myocardial (NT-proBNP) and fibrosis (sST2) as potential additional markers of CHF patients' βresponseβ to CRT and CCM.Aim: To evaluate the potential to use NT-proBNP and sST2 biomarkers in CHF patients combined with transthoracic echocardiography (Echo) and contrast magnetic resonance imaging (MRI) parameters of the heart to predict a positive response to CRT and CCM devices.Materials and methods: The study included 51 patients (41 men, 10 women) aged 58 Β± 12 years (26 to 79 years) with ischemic heart disease post acute myocardial infarction (n = 22) or non-ischemic cardiomyopathy (n = 29), left ventricle (LV) ejection fraction (EF) 35%, and CHF IIβIII NYHA functional class despite β₯ 3 months of optimized medical therapy. The patients were assessed by serum biomarkers NT-proBNP and sST2 measurements, transthoracic Echo, and contrast- enhanced cardiac MRI. After the diagnostic assessment, CRT defibrillators (CRT-D) were implanted to 39 patients and CCM to 12 patients. After prospective follow-up of the patients for 18 to 24 months, predictors of the response to each device type were analyzed in univariate, multivariate, and ROC analysis.Results: The response to CRT-D was found in 21 (54%) patients, to CCM in 7 (58%) patients. Multivariate analysis showed the following predictors of the response of patients to CRT-D were: 1) sST2 50 ng/mL, 2) NT-proBNP 3900 pg/mL, 3) 3 LV segments with fibrosis (by MRI) and 4) anteroposterior dimension of the left atrium 4.8 cm (by Echo). Any 2 of these 4 characteristics made it possible to predict the response to CRT with an accuracy of 87% (sensitivity 90%, specificity 83%). The predictors of the response to CCM were: 1) sST2 30 ng/ml, 2) LV end diastolic diameter 78 mm (Echo), 3) age 56 years, 4) body mass index 27 kg/m2. Any 2 of these 4 characteristics predicted the positive response to CCM with an accuracy of 92% (sensitivity 86%, specificity 100%).Conclusion: The preoperative sST2 level was the only universal marker of the response to either CRT ( 50 ng/mL) or CCM ( 30 ng/mL) devices in CHF patients with reduced LVEF. The results indicate the potential for improved efficacy of these devices with their earlier implantation after the onset of the heart disease, as well as provided that maximal control CHF in these patients has been achieved.ΠΠ±ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΠ΅. ΠΠΎ Π΄Π°Π½Π½ΡΠΌ ΠΌΠ½ΠΎΠ³ΠΎΡΠΈΡΠ»Π΅Π½Π½ΡΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ, ΠΎΡ 30 Π΄ΠΎ 50% ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠ΅ΡΠ΄Π΅ΡΠ½ΠΎΠΉ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎΡΡΡΡ (Π₯Π‘Π) ΠΎΠΊΠ°Π·ΡΠ²Π°ΡΡΡΡ Π½Π΅Π²ΠΎΡΠΏΡΠΈΠΈΠΌΡΠΈΠ²Ρ ΠΊ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΡΠ΅ΡΠ΄Π΅ΡΠ½ΠΎΠΉ ΡΠ΅ΡΠΈΠ½Ρ
ΡΠΎΠ½ΠΈΠ·ΠΈΡΡΡΡΠ΅ΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ (Π‘Π Π’) ΠΈ ΠΌΠΎΠ΄ΡΠ»ΡΡΠΈΠΈ ΡΠ΅ΡΠ΄Π΅ΡΠ½ΠΎΠΉ ΡΠΎΠΊΡΠ°ΡΠΈΠΌΠΎΡΡΠΈ (ΠΠ‘Π‘), Π½Π΅ΡΠΌΠΎΡΡΡ Π½Π° ΡΡΠ°ΡΠ΅Π»ΡΠ½ΡΠΉ ΠΎΡΠ±ΠΎΡ Π±ΠΎΠ»ΡΠ½ΡΡ
Π² ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²ΠΈΠΈ Ρ ΡΡΡΠ΅ΡΡΠ²ΡΡΡΠΈΠΌΠΈ ΡΠ΅ΠΊΠΎΠΌΠ΅Π½Π΄Π°ΡΠΈΡΠΌΠΈ. ΠΡΠ΅Π΄ΡΡΠ°Π²Π»ΡΠ΅Ρ ΠΈΠ½ΡΠ΅ΡΠ΅Ρ ΠΈΠ·ΡΡΠ΅Π½ΠΈΠ΅ Π½Π΅ΠΉΡΠΎΠ³ΠΎΡΠΌΠΎΠ½ΠΎΠ², ΠΎΡΡΠ°ΠΆΠ°ΡΡΠΈΡ
ΠΏΡΠΎΡΠ΅ΡΡΡ Π½Π°ΠΏΡΡΠΆΠ΅Π½ΠΈΡ (NT-proBNP) ΠΈ ΡΠΈΠ±ΡΠΎΠ·Π° (sST2) ΠΌΠΈΠΎΠΊΠ°ΡΠ΄Π°, Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΡΡ
Π΄ΠΎΠΏΠΎΠ»Π½ΠΈΡΠ΅Π»ΡΠ½ΡΡ
ΠΌΠ°ΡΠΊΠ΅ΡΠΎΠ² ΠΎΡΠ²Π΅ΡΠ° Π±ΠΎΠ»ΡΠ½ΡΡ
Π₯Π‘Π Π½Π° ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΡΡΡΡΠΎΠΉΡΡΠ² Π‘Π Π’ ΠΈ ΠΠ‘Π‘.Π¦Π΅Π»Ρ β ΠΈΠ·ΡΡΠΈΡΡ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π₯Π‘Π Π±ΠΈΠΎΠΌΠ°ΡΠΊΠ΅ΡΠΎΠ² NT-proBNP ΠΈ sST2 Π² ΠΊΠΎΠΌΠ±ΠΈΠ½Π°ΡΠΈΠΈ Ρ ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΠ°ΠΌΠΈ ΡΡΠ°Π½ΡΡΠΎΡΠ°ΠΊΠ°Π»ΡΠ½ΠΎΠΉ ΡΡ
ΠΎΠΊΠ°ΡΠ΄ΠΈΠΎΠ³ΡΠ°ΡΠΈΠΈ (ΠΡ
ΠΎΠΠ) ΠΈ ΠΌΠ°Π³Π½ΠΈΡΠ½ΠΎ-ΡΠ΅Π·ΠΎΠ½Π°Π½ΡΠ½ΠΎΠΉ ΡΠΎΠΌΠΎΠ³ΡΠ°ΡΠΈΠΈ (ΠΠ Π’) ΡΠ΅ΡΠ΄ΡΠ° Ρ ΠΊΠΎΠ½ΡΡΠ°ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ Π΄Π»Ρ ΠΏΡΠΎΠ³Π½ΠΎΠ·ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΏΠΎΠ»ΠΎΠΆΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΠΎΡΠ²Π΅ΡΠ° Π½Π° ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΡΡΡΡΠΎΠΉΡΡΠ² Π‘Π Π’ ΠΈ ΠΠ‘Π‘.ΠΠ°ΡΠ΅ΡΠΈΠ°Π» ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. Π ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Π²ΠΊΠ»ΡΡΠ΅Π½ 51 ΠΏΠ°ΡΠΈΠ΅Π½Ρ (41 ΠΌΡΠΆΡΠΈΠ½Π°, 10 ΠΆΠ΅Π½ΡΠΈΠ½, ΡΡΠ΅Π΄Π½ΠΈΠΉ Π²ΠΎΠ·ΡΠ°ΡΡ ΡΠΎΡΡΠ°Π²ΠΈΠ» 58 Β± 12 Π»Π΅Ρ (ΠΎΡ 26 Π΄ΠΎ 79 Π»Π΅Ρ)) Ρ ΠΏΠΎΡΡΠΈΠ½ΡΠ°ΡΠΊΡΠ½ΡΠΌ ΠΊΠ°ΡΠ΄ΠΈΠΎΡΠΊΠ»Π΅ΡΠΎΠ·ΠΎΠΌ (n = 22) ΠΈΠ»ΠΈ Π½Π΅ΠΈΡΠ΅ΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΊΠ°ΡΠ΄ΠΈΠΎΠΌΠΈΠΎΠΏΠ°ΡΠΈΠ΅ΠΉ (n = 29), ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΠ΅ΠΌ ΡΡΠ°ΠΊΡΠΈΠΈ Π²ΡΠ±ΡΠΎΡΠ° Π»Π΅Π²ΠΎΠ³ΠΎ ΠΆΠ΅Π»ΡΠ΄ΠΎΡΠΊΠ° ΠΌΠ΅Π½Π΅Π΅ 35% ΠΈ ΠΏΡΠΈΠ·Π½Π°ΠΊΠ°ΠΌΠΈ Π₯Π‘Π IIβIII ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΊΠ»Π°ΡΡΠ° ΠΏΠΎ NYHA, Ρ ΠΊΠΎΡΠΎΡΡΡ
Π² ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ Π½Π΅ ΠΌΠ΅Π½Π΅Π΅ 3 ΠΌΠ΅ΡΡΡΠ΅Π² ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»Π°ΡΡ ΠΎΠΏΡΠΈΠΌΠ°Π»ΡΠ½Π°Ρ ΠΌΠ΅Π΄ΠΈΠΊΠ°ΠΌΠ΅Π½ΡΠΎΠ·Π½Π°Ρ ΡΠ΅ΡΠ°ΠΏΠΈΡ. ΠΠ±ΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Π²ΠΊΠ»ΡΡΠ°Π»ΠΎ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠ΅ ΠΡ
ΠΎΠΠ, ΠΠ Π’ ΡΠ΅ΡΠ΄ΡΠ° Ρ ΠΊΠΎΠ½ΡΡΠ°ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ, Π° ΡΠ°ΠΊΠΆΠ΅ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ Π·Π½Π°ΡΠ΅Π½ΠΈΠΉ Π±ΠΈΠΎΠΌΠ°ΡΠΊΠ΅ΡΠΎΠ² NT-proBNP ΠΈ sST2. ΠΠΎ ΠΎΠΊΠΎΠ½ΡΠ°Π½ΠΈΠΈ ΠΎΠ±ΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ 39 Π±ΠΎΠ»ΡΠ½ΡΠΌ Π±ΡΠ»ΠΈ ΠΈΠΌΠΏΠ»Π°Π½ΡΠΈΡΠΎΠ²Π°Π½Ρ Π‘Π Π’, 12 β ΠΠ‘Π‘. ΠΠΎ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ°ΠΌ ΠΏΡΠΎΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠ³ΠΎ Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΡ Π½Π° ΠΏΡΠΎΡΡΠΆΠ΅Π½ΠΈΠΈ 18β24 ΠΌΠ΅ΡΡΡΠ΅Π² Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² ΠΎΠ΄Π½ΠΎΡΠ°ΠΊΡΠΎΡΠ½ΠΎΠ³ΠΎ, ΠΌΠ½ΠΎΠ³ΠΎΡΠ°ΠΊΡΠΎΡΠ½ΠΎΠ³ΠΎ ΠΈ ROC- Π°Π½Π°Π»ΠΈΠ·Π° ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ ΠΏΠΎΠΈΡΠΊ ΠΏΡΠ΅Π΄ΠΈΠΊΡΠΎΡΠΎΠ² ΠΎΡΠ²Π΅ΡΠ° Π½Π° ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΠΊΠ°ΠΆΠ΄ΠΎΠ³ΠΎ ΡΠΈΠΏΠ° ΡΡΡΡΠΎΠΉΡΡΠ².Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. ΠΡΠΈΠ·Π½Π°ΠΊΠΈ ΠΏΠΎΠ»ΠΎΠΆΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΠΎΡΠ²Π΅ΡΠ° Π½Π° ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ Π‘Π Π’-ΡΡΡΡΠΎΠΉΡΡΠ² Ρ ΡΡΠ½ΠΊΡΠΈΠ΅ΠΉ Π΄Π΅ΡΠΈΠ±ΡΠΈΠ»Π»ΡΡΠΎΡΠ° (Π‘Π Π’-Π) ΡΠ΅Π³ΠΈΡΡΡΠΈΡΠΎΠ²Π°Π»ΠΈΡΡ Ρ 21 (54%) ΠΏΠ°ΡΠΈΠ΅Π½ΡΠ°, Π½Π° ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΠ‘Π‘ β Ρ 7 (58%) Π±ΠΎΠ»ΡΠ½ΡΡ
. ΠΠΎ ΠΈΡΠΎΠ³Π°ΠΌ ΠΌΠ½ΠΎΠ³ΠΎΡΠ°ΠΊΡΠΎΡΠ½ΠΎΠ³ΠΎ Π°Π½Π°Π»ΠΈΠ·Π°, ΠΏΡΠ΅Π΄ΠΈΠΊΡΠΎΡΠ°ΠΌΠΈ ΡΠ°ΠΊΠΎΠ³ΠΎ ΠΎΡΠ²Π΅ΡΠ° Π½Π° ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ Π‘Π Π’-Π Π±ΡΠ»ΠΈ: 1) Π·Π½Π°ΡΠ΅Π½ΠΈΠ΅ sST2 50 Π½Π³/ΠΌΠ», 2) Π·Π½Π°ΡΠ΅Π½ΠΈΠ΅ NT-proBNP 3900 ΠΏΠ³/ΠΌΠ», 3) Π½Π°Π»ΠΈΡΠΈΠ΅ Π² Π»Π΅Π²ΠΎΠΌ ΠΆΠ΅Π»ΡΠ΄ΠΎΡΠΊΠ΅ ΠΌΠ΅Π½Π΅Π΅ 3 ΡΠ΅Π³ΠΌΠ΅Π½ΡΠΎΠ² Ρ ΡΠΈΠ±ΡΠΎΠ·ΠΎΠΌ (ΠΏΠΎ ΠΠ Π’ ΡΠ΅ΡΠ΄ΡΠ°) ΠΈ 4) ΠΏΠ΅ΡΠ΅Π΄Π½Π΅-Π·Π°Π΄Π½ΠΈΠΉ ΡΠ°Π·ΠΌΠ΅Ρ Π»Π΅Π²ΠΎΠ³ΠΎ ΠΏΡΠ΅Π΄ΡΠ΅ΡΠ΄ΠΈΡ 4,8 ΡΠΌ (ΠΏΠΎ ΠΡ
ΠΎΠΠ). ΠΠ°Π»ΠΈΡΠΈΠ΅ 2 ΠΈΠ· 4 Π²ΡΡΠ΅ΠΏΠ΅ΡΠ΅ΡΠΈΡΠ»Π΅Π½Π½ΡΡ
ΠΏΡΠΈΠ·Π½Π°ΠΊΠΎΠ² ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ»ΠΎ ΠΏΡΠΎΠ³Π½ΠΎΠ·ΠΈΡΠΎΠ²Π°ΡΡ ΠΏΠΎΠ»ΠΎΠΆΠΈΡΠ΅Π»ΡΠ½ΡΠΉ ΠΎΡΠ²Π΅Ρ Π½Π° ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ Π‘Π Π’ Ρ ΡΠΎΡΠ½ΠΎΡΡΡΡ 87% (ΡΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΡ 90%, ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ½ΠΎΡΡΡ 83%). ΠΡΠ΅Π΄ΠΈΠΊΡΠΎΡΠ°ΠΌΠΈ ΠΏΠΎΠ»ΠΎΠΆΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΠΎΡΠ²Π΅ΡΠ° Π±ΠΎΠ»ΡΠ½ΡΡ
Π½Π° ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΠΠ‘Π‘ ΡΠ»ΡΠΆΠΈΠ»ΠΈ: 1) Π·Π½Π°ΡΠ΅Π½ΠΈΠ΅ sST2 30 Π½Π³/ΠΌΠ», 2) ΠΊΠΎΠ½Π΅ΡΠ½ΠΎ-Π΄ΠΈΠ°ΡΡΠΎΠ»ΠΈΡΠ΅ΡΠΊΠΈΠΉ ΡΠ°Π·ΠΌΠ΅Ρ Π»Π΅Π²ΠΎΠ³ΠΎ ΠΆΠ΅Π»ΡΠ΄ΠΎΡΠΊΠ° 78 ΠΌΠΌ (ΠΏΠΎ ΠΡ
ΠΎΠΠ), 3) Π²ΠΎΠ·ΡΠ°ΡΡ 56 Π»Π΅Ρ, 4) Π·Π½Π°ΡΠ΅Π½ΠΈΠ΅ ΠΈΠ½Π΄Π΅ΠΊΡΠ° ΠΌΠ°ΡΡΡ ΡΠ΅Π»Π° 27 ΠΊΠ³/ΠΌ2. ΠΠ°Π»ΠΈΡΠΈΠ΅ 2 ΠΈΠ· 4 ΠΏΡΠΈΠ·Π½Π°ΠΊΠΎΠ² ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ»ΠΎ ΠΏΡΠΎΠ³Π½ΠΎΠ·ΠΈΡΠΎΠ²Π°ΡΡ ΠΏΠΎΠ»ΠΎΠΆΠΈΡΠ΅Π»ΡΠ½ΡΠΉ ΠΎΡΠ²Π΅Ρ Π½Π° ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΠΠ‘Π‘ Ρ ΡΠΎΡΠ½ΠΎΡΡΡΡ 92% (ΡΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΡ 86%, ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ½ΠΎΡΡΡ 100%).ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. ΠΠ΄ΠΈΠ½ΡΡΠ²Π΅Π½Π½ΡΠΌ ΡΠ½ΠΈΠ²Π΅ΡΡΠ°Π»ΡΠ½ΡΠΌ ΠΌΠ°ΡΠΊΠ΅ΡΠΎΠΌ ΠΎΡΠΊΠ»ΠΈΠΊΠ° Π±ΠΎΠ»ΡΠ½ΡΡ
Π₯Π‘Π ΡΠΎ ΡΠ½ΠΈΠΆΠ΅Π½Π½ΠΎΠΉ ΡΡΠ°ΠΊΡΠΈΠ΅ΠΉ Π²ΡΠ±ΡΠΎΡΠ° Π»Π΅Π²ΠΎΠ³ΠΎ ΠΆΠ΅Π»ΡΠ΄ΠΎΡΠΊΠ° Π½Π° ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΠΎΠ±ΠΎΠΈΡ
ΡΠΈΠΏΠΎΠ² ΡΡΡΡΠΎΠΉΡΡΠ² Π±ΡΠ»ΠΈ ΠΈΡΡ
ΠΎΠ΄Π½ΡΠ΅ Π·Π½Π°ΡΠ΅Π½ΠΈΡ sST2 ( 50 Π½Π³/ΠΌΠ» Π΄Π»Ρ Π‘Π Π’-Π ΠΈ 30 Π½Π³/ΠΌΠ» Π΄Π»Ρ ΠΠ‘Π‘). ΠΡΠΎ ΡΠΊΠ°Π·ΡΠ²Π°Π΅Ρ Π½Π° ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΡΡ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡ ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΡ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ Π²ΡΡΠ΅ΠΎΠΏΠΈΡΠ°Π½Π½ΡΡ
ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² ΠΏΡΠΈ ΠΈΡ
ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠΈ Π² Π±ΠΎΠ»Π΅Π΅ ΡΠ°Π½Π½ΠΈΠ΅ ΡΡΠΎΠΊΠΈ ΠΎΡ Π΄Π΅Π±ΡΡΠ° Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ, Π° ΡΠ°ΠΊΠΆΠ΅ ΠΏΠΎΡΠ»Π΅ Π΄ΠΎΡΡΠΈΠΆΠ΅Π½ΠΈΡ ΠΌΠ°ΠΊΡΠΈΠΌΠ°Π»ΡΠ½ΠΎ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΠΉ ΠΊΠΎΠΌΠΏΠ΅Π½ΡΠ°ΡΠΈΠΈ ΡΠ²Π»Π΅Π½ΠΈΠΉ Π₯Π‘Π Ρ Π΄Π°Π½Π½ΠΎΠΉ ΠΊΠ°ΡΠ΅Π³ΠΎΡΠΈΠΈ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ²